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PD-L1 Testing for L...
PD-L1 Testing for Lung Cancer in 2019 : Perspective From the IASLC Pathology Committee
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- Lantuejoul, Sylvie (författare)
- Ctr Leon Berard Unicanc, Lyon, France.;Univ Grenoble Alpes, Grenoble, France.
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- Sound-Tsao, Ming (författare)
- Univ Hlth Network, Princess Margaret Canc Ctr, Toronto, ON, Canada.
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- Cooper, Wendy A. (författare)
- Royal Prince Alfred Hosp, Camperdown, NSW, Australia.
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- Girard, Nicolas (författare)
- Inst Curie, Paris, France.;Univ Claude Bernard, Lyon, France.
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- Hirsch, Fred R. (författare)
- Tisch Canc Inst, Ctr Thorac Oncol, New York, NY USA.;Mt Sinai Hlth Syst, Ichan Sch Med, New York, NY USA.
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- Roden, Anja C. (författare)
- Mayo Clin, Rochester, MN USA.
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- Lopez-Rios, Fernando (författare)
- HM Hosp, Pathol Lab Dianas Terapeut, Madrid, Spain.
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- Jain, Deepali (författare)
- All India Inst Med Sci, New Delhi, India.
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- Chou, Teh-Ying (författare)
- Taipei Vet Gen Hosp, Taipei, Taiwan.
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- Motoi, Noriko (författare)
- Natl Canc Ctr, Tokyo, Japan.
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- Kerr, Keith M. (författare)
- Aberdeen Royal Infirm, Dept Pathol, Aberdeen, Scotland.
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Yatabe, Yasushi (författare)
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- Brambilla, Elisabeth (författare)
- Univ Grenoble Alpes, Grenoble, France.
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- Longshore, John (författare)
- Carolinas Pathol Grp, Charlotte, NC USA.
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- Papotti, Mauro (författare)
- Univ Turin, Turin, Italy.
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- Sholl, Lynette M. (författare)
- Brigham & Womens Hosp, Dept Pathol, 75 Francis St, Boston, MA 02115 USA. Harvard Med Sch, Dept Pathol, Boston, MA 02115 USA.
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- Thunnissen, Erik (författare)
- Vrije Univ Amsterdam, Dept Pathol, Med Ctr, Amsterdam, Netherlands.
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- Rekhtman, Natasha (författare)
- Mem Sloan Kettering Canc Ctr, 1275 York Ave, New York, NY 10021 USA.
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- Borczuk, Alain (författare)
- Weill Cornell Med, New York, NY USA.
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- Bubendorf, Lukas (författare)
- Univ Basel, Inst Pathol, Basel, Switzerland.
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- Minami, Yuko (författare)
- Ibarakihigashi Natl Hosp, Tokai, Ibaraki, Japan.
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- Beasley, Mary Beth (författare)
- Mt Sinai Hlth Syst, Ichan Sch Med, New York, NY USA.
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- Botling, Johan (författare)
- Uppsala universitet,Klinisk och experimentell patologi,Uppsala Univ Hosp, Uppsala, Sweden,Johan Botling
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- Chen, Gang (författare)
- Fudan Univ, Zhongshan Hosp, Shanghai, Peoples R China.
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- Chung, Jin-Haeng (författare)
- Seoul Natl Univ, Bundang Hosp, Seoul, South Korea.
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- Dacic, Sanja (författare)
- Univ Pittsburgh, Med Ctr, Pittsburgh, PA USA.
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- Hwang, David (författare)
- Sunnybrook Hlth Sci Ctr, Toronto, ON, Canada.
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- Lin, Dongmei (författare)
- Peking Univ, Canc Hosp & Inst, Dept Pathol, Beijing, Peoples R China.
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- Moreira, Andre (författare)
- NYU, Sch Med, New York, NY USA.
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- Nicholson, Andrew G. (författare)
- Royal Brompton & Harefield NHS Fdn Trust, London, England.;Imperial Coll, Natl Heart & Lung Inst, London, England.
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- Noguchi, Masayuki (författare)
- Univ Tsukuba, Tsukuba, Ibaraki, Japan.
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- Pelosi, Giuseppe (författare)
- Univ Milan, Milan, Italy.;IRCCS MultiMed, Milan, Italy.
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- Poleri, Claudia (författare)
- Off Pathol Consultants, Buenos Aires, DF, Argentina.
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- Travis, William (författare)
- Mem Sloan Kettering Canc Ctr, 1275 York Ave, New York, NY 10021 USA.
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- Yoshida, Akihiko (författare)
- Natl Canc Ctr, Tokyo, Japan.
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- Daigneault, Jillian B. (författare)
- Int Assoc Study Lung Canc, Aurora, CO USA.
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- Wistuba, Ignacio I. (författare)
- Univ Texas MD Anderson Canc Ctr, Houston, TX 77030 USA.
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- Mino-Kenudson, Mari (författare)
- Massachusetts Gen Hosp, Dept Pathol, 55 Fruit St,Warren 122, Boston, MA 02114 USA.
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Ctr Leon Berard Unicanc, Lyon, France;Univ Grenoble Alpes, Grenoble, France. Univ Hlth Network, Princess Margaret Canc Ctr, Toronto, ON, Canada. (creator_code:org_t)
- Elsevier BV, 2020
- 2020
- Engelska.
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Ingår i: Journal of Thoracic Oncology. - : Elsevier BV. - 1556-0864 .- 1556-1380. ; 15:4, s. 499-519
- Relaterad länk:
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http://www.jto.org/a...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- The recent development of immune checkpoint inhibitors (ICIs) has led to promising advances in the treatment of patients with NSCLC and SCLC with advanced or metastatic disease. Most ICIs target programmed cell death protein 1 (PD-1) or programmed death ligand 1 (PD-L1) axis with the aim of restoring antitumor immunity. Multiple clinical trials for ICIs have evaluated a predictive value of PD-L1 protein expression in tumor cells and tumor-infiltrating immune cells (ICs) by immunohistochemistry (IHC), for which different assays with specific IHC platforms were applied. Of those, some PD-L1 IHC assays have been validated for the prescription of the corresponding agent for first- or second-line treatment. However, not all laboratories are equipped with the dedicated platforms, and many laboratories have set up in-house or laboratory-developed tests that are more affordable than the generally expensive clinical trial-validated assays. Although PD-L1 IHC test is now deployed in most pathology laboratories, its appropriate implementation and interpretation are critical as a predictive biomarker and can be challenging owing to the multiple antibody clones and platforms or assays available and given the typically small size of samples provided. Because many articles have been published since the issue of the IASLC Atlas of PD-L1 Immunohistochemistry Testing in Lung Cancer, this review by the IASLC Pathology Committee provides updates on the indications of ICIs for lung cancer in 2019 and discusses important considerations on preanalytical, analytical, and postanalytical aspects of PD-L1 IHC testing, including specimen type, validation of assays, external quality assurance, and training.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Klinisk laboratoriemedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Clinical Laboratory Medicine (hsv//eng)
Nyckelord
- PD-L1
- Immunohistochemistry
- NSCLC
- SCLC
- Immunotherapy
- Patologi
- Pathology
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Lantuejoul, Sylv ...
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Sound-Tsao, Ming
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Cooper, Wendy A.
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Girard, Nicolas
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Hirsch, Fred R.
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Roden, Anja C.
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visa fler...
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Lopez-Rios, Fern ...
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Jain, Deepali
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Chou, Teh-Ying
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Motoi, Noriko
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Kerr, Keith M.
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Yatabe, Yasushi
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Brambilla, Elisa ...
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Longshore, John
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Papotti, Mauro
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Sholl, Lynette M ...
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Thunnissen, Erik
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Rekhtman, Natash ...
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Borczuk, Alain
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Bubendorf, Lukas
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Minami, Yuko
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Beasley, Mary Be ...
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Botling, Johan
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Chen, Gang
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Chung, Jin-Haeng
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Dacic, Sanja
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Hwang, David
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Lin, Dongmei
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Moreira, Andre
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Nicholson, Andre ...
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Noguchi, Masayuk ...
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Pelosi, Giuseppe
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Poleri, Claudia
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Travis, William
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Yoshida, Akihiko
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Daigneault, Jill ...
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Wistuba, Ignacio ...
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Mino-Kenudson, M ...
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