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Indoor microbiome, ...
Indoor microbiome, environmental characteristics and asthma among junior high school students in Johor Bahru, Malaysia
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- Fu, Xi (author)
- Sun Yat Sen Univ, Sch Publ Hlth, Dept Occupat & Environm Hlth, Guangzhou, Peoples R China.;South China Agr Univ, Coll Life Sci, Guangdong Prov Key Lab Prot Funct & Regulat Agr O, Guangzhou 510642, Guangdong, Peoples R China.
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- Norbäck, Dan (author)
- Uppsala universitet,Arbets- och miljömedicin
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- Yuan, Qianqian (author)
- South China Agr Univ, Coll Life Sci, Guangdong Prov Key Lab Prot Funct & Regulat Agr O, Guangzhou 510642, Guangdong, Peoples R China.;South China Agr Univ, Minist Agr & Rural Affairs, Key Lab Zoonosis, Guangzhou 510642, Guangdong, Peoples R China.;South China Agr Univ, Guangdong Lab Lingnan Modern Agr, Guangzhou 510642, Guangdong, Peoples R China.
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- Li, Yanling (author)
- South China Agr Univ, Coll Life Sci, Guangdong Prov Key Lab Prot Funct & Regulat Agr O, Guangzhou 510642, Guangdong, Peoples R China.;South China Agr Univ, Minist Agr & Rural Affairs, Key Lab Zoonosis, Guangzhou 510642, Guangdong, Peoples R China.;South China Agr Univ, Guangdong Lab Lingnan Modern Agr, Guangzhou 510642, Guangdong, Peoples R China.
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- Zhu, Xunhua (author)
- South China Agr Univ, Coll Life Sci, Guangdong Prov Key Lab Prot Funct & Regulat Agr O, Guangzhou 510642, Guangdong, Peoples R China.;South China Agr Univ, Minist Agr & Rural Affairs, Key Lab Zoonosis, Guangzhou 510642, Guangdong, Peoples R China.;South China Agr Univ, Guangdong Lab Lingnan Modern Agr, Guangzhou 510642, Guangdong, Peoples R China.
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- Hashim, Jamal Hisham (author)
- United Nations Univ, Int Inst Global Hlth, Kuala Lumpur, Malaysia.;Natl Univ Malaysia, Dept Community Hlth, Kuala Lumpur, Malaysia.
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- Hashim, Zailina (author)
- Univ Putra Malaysia, Dept Environm & Occupat Hlth, Fac Med & Hlth Sci, Serdang, Selangor, Malaysia.
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- Ali, Faridah (author)
- Johor State Hlth Dept, Primary Care Unit, Johor Baharu, Malaysia.
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- Zheng, Yi-Wu (author)
- ALK Abello AS, Asia Pacific Res, Guangzhou, Peoples R China.
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- Lai, Xu-Xin (author)
- ALK Abello AS, Asia Pacific Res, Guangzhou, Peoples R China.
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- Spangfort, Michael Dho (author)
- ALK Abello AS, Asia Pacific Res, Guangzhou, Peoples R China.
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- Deng, Yiqun (author)
- South China Agr Univ, Coll Life Sci, Guangdong Prov Key Lab Prot Funct & Regulat Agr O, Guangzhou 510642, Guangdong, Peoples R China.;South China Agr Univ, Minist Agr & Rural Affairs, Key Lab Zoonosis, Guangzhou 510642, Guangdong, Peoples R China.;South China Agr Univ, Guangdong Lab Lingnan Modern Agr, Guangzhou 510642, Guangdong, Peoples R China.
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- Sun, Yu (author)
- South China Agr Univ, Coll Life Sci, Guangdong Prov Key Lab Prot Funct & Regulat Agr O, Guangzhou 510642, Guangdong, Peoples R China.;South China Agr Univ, Minist Agr & Rural Affairs, Key Lab Zoonosis, Guangzhou 510642, Guangdong, Peoples R China.;South China Agr Univ, Guangdong Lab Lingnan Modern Agr, Guangzhou 510642, Guangdong, Peoples R China.
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Sun Yat Sen Univ, Sch Publ Hlth, Dept Occupat & Environm Hlth, Guangzhou, Peoples R China;South China Agr Univ, Coll Life Sci, Guangdong Prov Key Lab Prot Funct & Regulat Agr O, Guangzhou 510642, Guangdong, Peoples R China. Arbets- och miljömedicin (creator_code:org_t)
- Elsevier BV, 2020
- 2020
- English.
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In: Environment International. - : Elsevier BV. - 0160-4120 .- 1873-6750. ; 138
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Abstract
Subject headings
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- Indoor microbial diversity and composition are suggested to affect the prevalence and severity of asthma by previous home microbiome studies, but no microbiome-health association study has been conducted in a school environment, especially in tropical countries. In this study, we collected floor dust and environmental characteristics from 21 classrooms, and health data related to asthma symptoms from 309 students, in junior high schools in Johor Bahru, Malaysia. The bacterial and fungal composition was characterized by sequencing 16s rRNA gene and internal transcribed spacer (ITS) region, and the absolute microbial concentration was quantified by qPCR. In total, 326 bacterial and 255 fungal genera were characterized. Five bacterial (Sphingobium, Rhodomicrobium, Shimwellia, Solirubrobacter, Pleurocapsa) and two fungal (Torulaspora and Leptosphaeriaceae) taxa were protective for asthma severity. Two bacterial taxa, Izhakiella and Robinsoniella, were positively associated with asthma severity. Several protective bacterial taxa including Rhodomicrobium, Shimwellia and Sphingobium have been reported as protective microbes in previous studies, whereas other taxa were first time reported. Environmental characteristics, such as age of building, size of textile curtain per room volume, occurrence of cockroaches, concentration of house dust mite allergens transferred from homes by the occupants, were involved in shaping the overall microbial community but not asthma-associated taxa; whereas visible dampness and mold, which did not change the overall microbial community for floor dust, was negatively associated with the concentration of protective bacteria Rhodomicrobium (beta =-2.86, p = 0.021) of asthma. The result indicates complex interactions between microbes, environmental characteristics and asthma symptoms. Overall, this is the first indoor microbiome study to characterize the asthma-associated microbes and their environmental determinant in the tropical area, promoting the understanding of microbial exposure and respiratory health in this region.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Lungmedicin och allergi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Respiratory Medicine and Allergy (hsv//eng)
Keyword
- Bacteria
- Fungi
- Microbial community
- Absolute quantity
- Wheezing
- Breathlessness
- Adolescence
- Dampness/visible mold
- Malaysia
- Johor Bahru
- Tropics
- Junior high school
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Fu, Xi
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Norbäck, Dan
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Yuan, Qianqian
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Li, Yanling
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Zhu, Xunhua
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Hashim, Jamal Hi ...
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show more...
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Hashim, Zailina
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Ali, Faridah
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Zheng, Yi-Wu
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Lai, Xu-Xin
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Spangfort, Micha ...
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Deng, Yiqun
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Sun, Yu
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Respiratory Medi ...
- Articles in the publication
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Environment Inte ...
- By the university
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Uppsala University