Sökning: WFRF:(Huang Yonggang) >
Enhancement of oste...
Enhancement of osteoblast cells osteogenic differentiation and bone regeneration by hydroxyapatite/phosphoester modified poly(amino acid)
-
- Xiong, Yi (författare)
- Sichuan Univ, Coll Phys, Chengdu 610065, Sichuan, Peoples R China.
-
- Huang, Jieyang (författare)
- Humboldt Univ, Dept Chem, Brook Taylor Str 2, D-12489 Berlin, Germany.
-
- Fu, Le (författare)
- Cent South Univ, Sch Mat Sci & Engn, Changsha 410083, Peoples R China.
-
visa fler...
-
- Ren, Haohao (författare)
- Sichuan Univ, Coll Phys, Chengdu 610065, Sichuan, Peoples R China.
-
- Li, Shuyang (författare)
- Sichuan Univ, Coll Phys, Chengdu 610065, Sichuan, Peoples R China.
-
- Xia, Wei, Associate Professor (författare)
- Uppsala universitet,Tillämpad materialvetenskap
-
- Yan, Yonggang (författare)
- Sichuan Univ, Coll Phys, Chengdu 610065, Sichuan, Peoples R China.
-
visa färre...
-
Sichuan Univ, Coll Phys, Chengdu 610065, Sichuan, Peoples R China Humboldt Univ, Dept Chem, Brook Taylor Str 2, D-12489 Berlin, Germany. (creator_code:org_t)
- ELSEVIER, 2020
- 2020
- Engelska.
-
Ingår i: Materials science & engineering. C, biomimetic materials, sensors and systems. - : ELSEVIER. - 0928-4931 .- 1873-0191. ; 111
- Relaterad länk:
-
https://urn.kb.se/re...
-
visa fler...
-
https://doi.org/10.1...
-
visa färre...
Abstract
Ämnesord
Stäng
- Hydroxyapatite/poly(amino acid) (HA/PAA) has been used to treat a variety of long bone and vertebral bony defects, and a further biocompatibility improvement is a key for better application. Phosphoester (PE) contained materials are highly biocompatible but could hardly treat massive bone defects due to its fast-degradation-derived mechanical instability. To address the problems of the two materials, we have incorporated PE molecule into the main chain of PAA by chemical bonding. As a result, the compressive strength of HA/PAA with 1 wt% and 2.5 wt% PE maintained in the range of 80-150 MPa after soaking in PBS for 12 weeks, which could be attributed to the amplified hydrogen-bonding inside composites. Besides, the PE-containing HA/PAAs with increased hydrophilic function groups (O = P-O bonds and O = P-N), created a more favourable surface for cell adhesion. Meanwhile, compared with HA/PAA, the PE-containing HA/PAAs had a fast minerlization speed and promoted cell osteogenic differentiation. Furthermore, the in vivo study indicated that PE-containing HA/PAAs could facilitate bone formation (4 weeks), and form a complete bone bridging (12 weeks) in a rabbit cranial bone defect. In summary, the HA/PE-m-PAAs possessed good mechanical stability, improved cytocompatibility and osteoconductivity, so the composites have a great potential for massive bone defect treatment.
Ämnesord
- NATURVETENSKAP -- Kemi -- Polymerkemi (hsv//swe)
- NATURAL SCIENCES -- Chemical Sciences -- Polymer Chemistry (hsv//eng)
Nyckelord
- Poly(amino acid)
- Phosphoester
- Stability
- Osteogenic differentiation
- Osteoconductivity
- Bone regeneration
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas