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Draft genome sequen...
Draft genome sequences of Hirudo medicinalis and salivary transcriptome of three closely related medicinal leeches
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- Babenko, Vladislav V. (författare)
- Fed Med Biol Agcy, Fed Res & Clin Ctr Phys Chem Med, 1a Malaya Pirogovskaya Str, Moscow 119435, Russia.
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- Podgorny, Oleg, V (författare)
- Fed Med Biol Agcy, Fed Res & Clin Ctr Phys Chem Med, 1a Malaya Pirogovskaya Str, Moscow 119435, Russia.;Russian Acad Sci, Koltzov Inst Dev Biol, 26 Vavilov Str, Moscow 119334, Russia.
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- Manuvera, Valentin A. (författare)
- Fed Med Biol Agcy, Fed Res & Clin Ctr Phys Chem Med, 1a Malaya Pirogovskaya Str, Moscow 119435, Russia.;Moscow Inst Phys & Technol, 9 Inst Skiy Per, Dolgoprudnyi 141700, Moscow Region, Russia.
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- Kasianov, Artem S. (författare)
- Moscow Inst Phys & Technol, 9 Inst Skiy Per, Dolgoprudnyi 141700, Moscow Region, Russia.;Russian Acad Sci, Vavilov Inst Gen Genet, 3 Gubkina Str, Moscow 119991, Russia.
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- Manolov, Alexander, I (författare)
- Fed Med Biol Agcy, Fed Res & Clin Ctr Phys Chem Med, 1a Malaya Pirogovskaya Str, Moscow 119435, Russia.
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- Grafskaia, Ekaterina N. (författare)
- Fed Med Biol Agcy, Fed Res & Clin Ctr Phys Chem Med, 1a Malaya Pirogovskaya Str, Moscow 119435, Russia.;Moscow Inst Phys & Technol, 9 Inst Skiy Per, Dolgoprudnyi 141700, Moscow Region, Russia.
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- Shirokov, Dmitriy A. (författare)
- Fed Med Biol Agcy, Fed Res & Clin Ctr Phys Chem Med, 1a Malaya Pirogovskaya Str, Moscow 119435, Russia.
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- Kurdyumov, Alexey S. (författare)
- Fed Med Biol Agcy, Fed Res & Clin Ctr Phys Chem Med, 1a Malaya Pirogovskaya Str, Moscow 119435, Russia.
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- Vinogradov, Dmitriy V. (författare)
- Russian Acad Sci, AA Kharkevich Inst Informat Transmiss Problems, 19 Bolshoi Karetnyi Per, Moscow 127051, Russia.;Skolkovo Inst Sci & Technol, 3 Nobelya Ulitsa Str, Moscow 121205, Russia.
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- Nikitina, Anastasia S. (författare)
- Fed Med Biol Agcy, Fed Res & Clin Ctr Phys Chem Med, 1a Malaya Pirogovskaya Str, Moscow 119435, Russia.;Moscow Inst Phys & Technol, 9 Inst Skiy Per, Dolgoprudnyi 141700, Moscow Region, Russia.
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- Kovalchuk, Sergey, I (författare)
- Fed Med Biol Agcy, Fed Res & Clin Ctr Phys Chem Med, 1a Malaya Pirogovskaya Str, Moscow 119435, Russia.;Russian Acad Sci, Shemyakin Ovchinnikov Inst Bioorgan Chem, 16-10 Miklukho Maklaya Str, Moscow 117997, Russia.
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- Anikanov, Nickolay A. (författare)
- Fed Med Biol Agcy, Fed Res & Clin Ctr Phys Chem Med, 1a Malaya Pirogovskaya Str, Moscow 119435, Russia.;Russian Acad Sci, Shemyakin Ovchinnikov Inst Bioorgan Chem, 16-10 Miklukho Maklaya Str, Moscow 117997, Russia.
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- Butenko, Ivan O. (författare)
- Fed Med Biol Agcy, Fed Res & Clin Ctr Phys Chem Med, 1a Malaya Pirogovskaya Str, Moscow 119435, Russia.
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- Pobeguts, Olga, V (författare)
- Fed Med Biol Agcy, Fed Res & Clin Ctr Phys Chem Med, 1a Malaya Pirogovskaya Str, Moscow 119435, Russia.
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- Matyushkina, Daria S. (författare)
- Fed Med Biol Agcy, Fed Res & Clin Ctr Phys Chem Med, 1a Malaya Pirogovskaya Str, Moscow 119435, Russia.
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- Rakitina, Daria, V (författare)
- Fed Med Biol Agcy, Fed Res & Clin Ctr Phys Chem Med, 1a Malaya Pirogovskaya Str, Moscow 119435, Russia.
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- Kostryukova, Elena S. (författare)
- Fed Med Biol Agcy, Fed Res & Clin Ctr Phys Chem Med, 1a Malaya Pirogovskaya Str, Moscow 119435, Russia.
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- Zgoda, Victor G. (författare)
- Russian Acad Med Sci, VN Orekhovich Res Inst Biomed Chem, 10 Pogodinskaja Str, Moscow 119832, Russia.
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- Baskova, Isolda P. (författare)
- Lomonosov Moscow State Univ, Fac Biol, 1-12 Leninskie Gory, Moscow 119991, Russia.
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- Trukhan, Vladimir M. (författare)
- IM Sechenov First Moscow State Med Univ, Minist Healthcare Russian Federat, Sechenovskiy Univ, Trubetskaya Str 8-2, Moscow 119991, Russia.
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- Gelfand, Mikhail S. (författare)
- Russian Acad Sci, AA Kharkevich Inst Informat Transmiss Problems, 19 Bolshoi Karetnyi Per, Moscow 127051, Russia.;Skolkovo Inst Sci & Technol, 3 Nobelya Ulitsa Str, Moscow 121205, Russia.;Natl Res Univ Higher Sch Econ, Fac Comp Sci, 20 Myasnitskaya Str, Moscow 101000, Russia.;Lomonosov Moscow State Univ, Fac Bioengn & Bioinformat, 1-73 Leninskie Gory, Moscow 119991, Russia.
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- Govorun, Vadim M. (författare)
- Fed Med Biol Agcy, Fed Res & Clin Ctr Phys Chem Med, 1a Malaya Pirogovskaya Str, Moscow 119435, Russia.;Moscow Inst Phys & Technol, 9 Inst Skiy Per, Dolgoprudnyi 141700, Moscow Region, Russia.
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- Schiöth, Helgi B. (författare)
- Uppsala universitet,Schiöth: Funktionell farmakologi,IM Sechenov First Moscow State Med Univ, Minist Healthcare Russian Federat, Sechenovskiy Univ, Trubetskaya Str 8-2, Moscow 119991, Russia
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- Lazarev, Vassili N. (författare)
- Fed Med Biol Agcy, Fed Res & Clin Ctr Phys Chem Med, 1a Malaya Pirogovskaya Str, Moscow 119435, Russia.;Moscow Inst Phys & Technol, 9 Inst Skiy Per, Dolgoprudnyi 141700, Moscow Region, Russia.
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Fed Med Biol Agcy, Fed Res & Clin Ctr Phys Chem Med, 1a Malaya Pirogovskaya Str, Moscow 119435, Russia Fed Med Biol Agcy, Fed Res & Clin Ctr Phys Chem Med, 1a Malaya Pirogovskaya Str, Moscow 119435, Russia.;Russian Acad Sci, Koltzov Inst Dev Biol, 26 Vavilov Str, Moscow 119334, Russia. (creator_code:org_t)
- 2020-04-29
- 2020
- Engelska.
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Ingår i: BMC Genomics. - : Springer Science and Business Media LLC. - 1471-2164. ; 21:1
- Relaterad länk:
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https://doi.org/10.1...
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https://uu.diva-port... (primary) (Raw object)
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https://bmcgenomics....
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- BackgroundSalivary cell secretion (SCS) plays a critical role in blood feeding by medicinal leeches, making them of use for certain medical purposes even today.ResultsWe annotated the Hirudo medicinalis genome and performed RNA-seq on salivary cells isolated from three closely related leech species, H. medicinalis, Hirudo orientalis, and Hirudo verbana. Differential expression analysis verified by proteomics identified salivary cell-specific gene expression, many of which encode previously unknown salivary components. However, the genes encoding known anticoagulants have been found to be expressed not only in salivary cells. The function-related analysis of the unique salivary cell genes enabled an update of the concept of interactions between salivary proteins and components of haemostasis.ConclusionsHere we report a genome draft of Hirudo medicinalis and describe identification of novel salivary proteins and new homologs of genes encoding known anticoagulants in transcriptomes of three medicinal leech species. Our data provide new insights in genetics of blood-feeding lifestyle in leeches.
Ämnesord
- NATURVETENSKAP -- Biologi -- Genetik (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Genetics (hsv//eng)
Nyckelord
- Leech H
- medicinalis
- Genome
- Haematophagy
- Anticoagulants
- Systems biology
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Babenko, Vladisl ...
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Podgorny, Oleg, ...
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Manuvera, Valent ...
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Kasianov, Artem ...
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Manolov, Alexand ...
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Grafskaia, Ekate ...
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visa fler...
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Shirokov, Dmitri ...
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Kurdyumov, Alexe ...
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Vinogradov, Dmit ...
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Nikitina, Anasta ...
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Kovalchuk, Serge ...
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Anikanov, Nickol ...
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Butenko, Ivan O.
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Pobeguts, Olga, ...
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Matyushkina, Dar ...
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Rakitina, Daria, ...
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Kostryukova, Ele ...
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Zgoda, Victor G.
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Baskova, Isolda ...
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Trukhan, Vladimi ...
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Gelfand, Mikhail ...
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Govorun, Vadim M ...
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Schiöth, Helgi B ...
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Lazarev, Vassili ...
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- Om ämnet
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- NATURVETENSKAP
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NATURVETENSKAP
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och Biologi
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och Genetik
- Artiklar i publikationen
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BMC Genomics
- Av lärosätet
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Uppsala universitet