Impact of cytogenetic abnormalities on outcomes of adult Philadelphia-negative acute lymphoblastic leukemia after allogeneic hematopoietic stem cell transplantation: a study by the Acute Leukemia Working Committee of the Center for International Blood and Marrow Transplant Research

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Lazaryan, AleksandrH Lee Moffitt Canc Ctr & Res Inst, Tampa, FL 33612 USA. (author)

Impact of cytogenetic abnormalities on outcomes of adult Philadelphia-negative acute lymphoblastic leukemia after allogeneic hematopoietic stem cell transplantation : a study by the Acute Leukemia Working Committee of the Center for International Blood and Marrow Transplant Research

Article/chapterEnglish2020

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2019-09-26
Ferrata Storti Foundation (Haematologica),2020
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LIBRIS-ID:oai:DiVA.org:uu-412335
https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-412335URI
https://doi.org/10.3324/haematol.2019.220756DOI
http://kipublications.ki.se/Default.aspx?queryparsed=id:143636768URI

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Language:English
Summary in:English

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Subject category:art swepub-publicationtype

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Cytogenetic risk stratification at diagnosis has long been one of the most useful tools to assess prognosis in acute lymphoblastic leukemia (ALL). To examine the prognostic impact of cytogenetic abnormalities on outcomes after allogeneic hematopoietic cell transplantation, we studied 1731 adults with Philadelphia-negative ALL in complete remission who underwent myeloablative or reduced intensity/non-myeloablative conditioning transplant from unrelated or matched sibling donors reported to the Center for International Blood and Marrow Transplant Research. A total of 632 patients had abnormal conventional metaphase cytogenetics. The leukemia-free survival and overall survival rates at 5 years after transplantation in patients with abnormal cytogenetics were 40% and 42%, respectively, which were similar to those in patients with a normal karyotype. Of the previously established cytogenetic risk classifications, modified Medical Research Council-Eastern Cooperative Oncology Group score was the only independent prognosticator of leukemia-free survival (P=0.03). In the multivariable analysis, monosomy 7 predicted post-transplant relapse [hazard ratio (HR)=2.11; 95% confidence interval (95% CI): 1.04-4.27] and treatment failure (HR=1.97; 95% CI: 1.20-3.24). Complex karyotype was prognostic for relapse (HR=1.69; 95% CI: 1.06-2.69), whereas t(8;14) predicted treatment failure (HR=2.85; 95% CI: 1.35-6.02) and overall mortality (HR=3.03; 95% CI: 1.44-6.41). This large study suggested a novel transplant-specific cytogenetic scheme with adverse [monosomy 7, complex karyotype, del(7q), t(8;14), t(11;19), del(7q), tetraploidy/near triploidy], intermediate (normal karyotype and all other abnormalities), and favorable (high hyperdiploidy) risks to prognosticate leukemia-free survival (P=0.02). Although some previously established high-risk Philadelphia-negative cytogenetic abnormalities in ALL can be overcome by transplantation, monosomy 7, complex karyotype, and t(8;14) continue to pose significant risks and yield inferior outcomes.

Subject headings and genre

MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Hematologi hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Hematology hsv//eng

Added entries (persons, corporate bodies, meetings, titles ...)

Dolan, MichelleUniv Minnesota, Med Ctr, Minneapolis, MN 55455 USA. (author)
Zhang, Mei-JieMed Coll Wisconsin, CIBMTR, Dept Med, Milwaukee, WI 53226 USA.;Med Coll Wisconsin, Inst Hlth & Equ, Div Biostat, Milwaukee, WI 53226 USA. (author)
Wang, Hai-LinMed Coll Wisconsin, CIBMTR, Dept Med, Milwaukee, WI 53226 USA. (author)
Kharfan-Dabaja, Mohamed A.Mayo Clin, Blood & Marrow Transplantat Program, Div Hematol Oncol, Jacksonville, FL 32224 USA. (author)
Marks, David, IUniv Hosp Bristol NHS Trust, Adult Bone Marrow Transplant, Bristol, Avon, England. (author)
Bejanyan, NelliH Lee Moffitt Canc Ctr & Res Inst, Dept Blood & Marrow Transplant & Cellular Immunot, Tampa, FL USA. (author)
Copelan, EdwardCarolinas HealthCare Syst, Atrium Hlth, Levine Canc Inst, Charlotte, NC USA. (author)
Majhail, Navneet S.Cleveland Clin, Taussig Canc Inst, Blood & Marrow Transplant Program, Cleveland, OH 44106 USA. (author)
Waller, Edmund K.Emory Univ, Winship Canc Inst, Dept Hematol & Med Oncol, Atlanta, GA 30322 USA. (author)
Chao, NelsonDuke Univ, Med Ctr, Dept Med, Div Cell Therapy & Hematol, Durham, NC 27710 USA. (author)
Prestidge, TimStarship Childrens Hosp, Blood & Canc Ctr, Auckland, New Zealand. (author)
Nishihori, TaigaH Lee Moffitt Canc Ctr & Res Inst, Dept Blood & Marrow Transplantat, Tampa, FL USA. (author)
Kebriaei, PartowUniv Texas MD Anderson Canc Ctr, Dept Stem Cell Transplantat, Div Canc Med, Houston, TX 77030 USA. (author)
Inamoto, YoshihiroNatl Canc Ctr, Div Hematopoiet Stem Cell Transplantat, Tokyo, Japan. (author)
Hamilton, BettyCleveland Clin, Taussig Canc Inst, Blood & Marrow Transplant Program, Cleveland, OH 44106 USA. (author)
Hashmi, Shahrukh K.Mayo Clin, Dept Internal Med, Rochester, MN USA.;King Faisal Specialist Hosp & Res Ctr, Oncol Ctr, Riyadh, Saudi Arabia. (author)
Kamble, Rammurti T.Baylor Coll Med, Ctr Cell & Gene Therapy, Div Hematol & Oncol, Houston, TX 77030 USA. (author)
Bacher, UlrikeBern Univ Hosp, Inselspital, Dept Hematol, Bern, Switzerland. (author)
Hildebrandt, Gerhard C.Univ Kentucky, Markey Canc Ctr, Lexington, KY USA. (author)
Stiff, Patrick J.Loyola Univ Med Ctr, Maywood, IL 60153 USA. (author)
McGuirk, JosephUniv Kansas, Med Ctr, Westwood, KS USA. (author)
Aldoss, IbrahimCity Hope Natl Med Ctr, Comprehens Canc Ctr, Duarte, CA USA. (author)
Beitinjaneh, Amer M.Univ Miami, Miami, FL USA. (author)
Muffly, LoriStanford Univ, Div Blood & Marrow Transplantat, Stanford, CA 94305 USA. (author)
Vij, RaviWashington Univ, Sch Med, Div Hematol & Oncol, St Louis, MO USA. (author)
Olsson, RichardKarolinska Institutet,Uppsala universitet,Centrum för klinisk forskning i Sörmland (CKFD),Karolinska Inst, Dept Lab Med, Stockholm, Sweden(Swepub:uu)riols677 (author)
Byrne, MichaelVanderbilt Univ, Med Ctr, Nashville, TN USA. (author)
Schultz, Kirk R.Univ British Columbia, British Columbias Childrens Hosp, Dept Pediat Hematol Oncol & Bone Marrow Transplan, Vancouver, BC, Canada. (author)
Aljurf, MahmoudKing Faisal Specialist Hosp & Res Ctr, Oncol Ctr, Riyadh, Saudi Arabia. (author)
Seftel, MatthewCancerCare Manitoba, Dept Med Oncol & Hematol, Winnipeg, MB, Canada. (author)
Savoie, Mary LynnTom Baker Canc Clin, Calgary, AB, Canada. (author)
Savani, Bipin N.Vanderbilt Univ, Med Ctr, Dept Med, Div Hematol Oncol, Nashville, TN USA. (author)
Verdonck, Leo F.Isala Clin, Dept Hematol Oncol, Zwolle, Netherlands. (author)
Cairo, Mitchell S.New York Med Coll, Dept Pediat, Div Pediat Hematol Oncol & Stem Cell Transplantat, Valhalla, NY 10595 USA. (author)
Hossain, NasheedLoyola Univ Chicago, Stritch Sch Med, Maywood, IL USA. (author)
Bhatt, Vijaya RajUniv Nebraska Med Ctr, Fred & Pamela Buffett Canc Ctr, Omaha, NE USA. (author)
Frangoul, Haydar A.Childrens Hosp TriStar Centennial, Nashville, TN USA.;Sarah Cannon Res Inst, Nashville, TN USA. (author)
Abdel-Azim, HishamUniv Southern Calif, Keck Sch Med, Childrens Hosp Los Angeles, Div Hematol Oncol & Blood & Marrow Transplantat, Los Angeles, CA 90007 USA. (author)
Al Malki, MonzrCity Hope Natl Med Ctr, Comprehens Canc Ctr, Duarte, CA USA. (author)
Munker, ReinholdLouisiana State Univ Hlth Shreveport, Dept Internal Med, Sect Hematol Oncol, Shreveport, LA USA. (author)
Rizzieri, DavidDuke Univ, Div Hematol Malignancies & Cellular Therapy, Durham, NC USA. (author)
Khera, NanditaMayo Clin, Dept Hematol Oncol, Phoenix, AZ USA. (author)
Nakamura, RyotaroCity Hope Natl Med Ctr, Dept Hematol & Hematopoiet Cell Transplantat, Duarte, CA USA. (author)
Ringden, OlleKarolinska Institutet (author)
van der Poel, MarjoleinAcad Ziekenhuis Maastricht, Maastricht, Netherlands. (author)
Murthy, Hemant S.Mayo Clin Florida, Jacksonville, FL USA. (author)
Liu, HongtaoUniv Chicago Med, Chicago, IL USA. (author)
Mori, ShahramFlorida Hosp Med Grp, Blood & Marrow Transplant Ctr, Orlando, FL USA. (author)
De Oliveira, SatiroUCLA, Med Ctr, Los Angeles, CA 90024 USA. (author)
Bolanos-Meade, JavierSidney Kimmel Comprehens Canc Ctr Johns Hopkins B, Baltimore, MD USA. (author)
Elsawy, MahmoudDalhousie Univ, QE II Hlth Sci Ctr, Halifax, NS, Canada. (author)
Barba, PereHosp Valle De Hebron, Barcelona, Spain. (author)
Nathan, SunitaRush Univ, Med Ctr, Chicago, IL 60612 USA. (author)
George, BijuChristian Med Coll & Hosp, Vellore, Tamil Nadu, India. (author)
Pawarode, AttapholUniv Michigan, Dept Internal Med, Div Hematol Oncol, Med Sch,Blood & Marrow Transplantat Program, Ann Arbor, MI USA. (author)
Grunwald, MichaelAtrium Hlth, Levine Canc Inst, Dept Hematol Oncol & Blood Disorders, Charlotte, NC USA. (author)
Agrawal, VaibhavIndiana Univ Sch Med, Div Hematol Oncol, Indianapolis, IN 46202 USA. (author)
Wang, YoujinNCI, Rockville, MD USA. (author)
Assal, AmerColumbia Univ, Med Ctr, New York Presbyterian Hosp, New York, NY USA. (author)
Caro, Paul CastilloUF Hlth Shands Childrens Hosp, Gainesville, FL USA. (author)
Kuwatsuka, YachiyoNagoya Univ Hosp, Dept Adv Med, Nagoya, Aichi, Japan. (author)
Seo, SachikoDokkyo Med Univ, Dept Hematol & Oncol, Mibu, Tochigi, Japan. (author)
Ustun, CelalettinRush Univ, Div Hematol Oncol Cell Therapy, Chicago, IL 60612 USA. (author)
Politikos, IoannisMem Sloan Kettering Canc Ctr, 1275 York Ave, New York, NY 10021 USA. (author)
Lazarus, Hillard M.Case Western Reserve Univ, Cleveland, OH 44106 USA. (author)
Saber, WaelMed Coll Wisconsin, CIBMTR, Dept Med, Milwaukee, WI 53226 USA. (author)
Sandmaier, Brenda M.Univ Washington, Div Med Oncol, Seattle, WA 98195 USA.;Fred Hutchinson Canc Res Ctr, Clin Res Div, 1124 Columbia St, Seattle, WA 98104 USA. (author)
De Lima, MarcosUniv Hosp Case Med Ctr, Seidman Canc Ctr, Dept Med, Cleveland, OH USA. (author)
Litzow, MarkMayo Clin Rochester, Div Hematol & Transplant Ctr, Rochester, MN USA. (author)
Bachanova, VeronikaUniv Minnesota, Med Ctr, Blood & Marrow Transplant Program, Minneapolis, MN 55455 USA. (author)
Weisdorf, DanielUniv Minnesota, Med Ctr, Dept Med, Div Hematol Oncol & Transplantat, Minneapolis, MN 55455 USA. (author)
H Lee Moffitt Canc Ctr & Res Inst, Tampa, FL 33612 USA.Univ Minnesota, Med Ctr, Minneapolis, MN 55455 USA. (creator_code:org_t)

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In:Haematologica: Ferrata Storti Foundation (Haematologica)105:5, s. 1329-13380390-60781592-8721

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By the author/editor: Lazaryan, Aleksa ...; Dolan, Michelle; Zhang, Mei-Jie; Wang, Hai-Lin; Kharfan-Dabaja, ...; Marks, David, I; show more...; Bejanyan, Nelli; Copelan, Edward; Majhail, Navneet ...; Waller, Edmund K ...; Chao, Nelson; Prestidge, Tim; Nishihori, Taiga; Kebriaei, Partow; Inamoto, Yoshihi ...; Hamilton, Betty; Hashmi, Shahrukh ...; Kamble, Rammurti ...; Bacher, Ulrike; Hildebrandt, Ger ...; Stiff, Patrick J ...; McGuirk, Joseph; Aldoss, Ibrahim; Beitinjaneh, Ame ...; Muffly, Lori; Vij, Ravi; Olsson, Richard; Byrne, Michael; Schultz, Kirk R.; Aljurf, Mahmoud; Seftel, Matthew; Savoie, Mary Lyn ...; Savani, Bipin N.; Verdonck, Leo F.; Cairo, Mitchell ...; Hossain, Nasheed; Bhatt, Vijaya Ra ...; Frangoul, Haydar ...; Abdel-Azim, Hish ...; Al Malki, Monzr; Munker, Reinhold; Rizzieri, David; Khera, Nandita; Nakamura, Ryotar ...; Ringden, Olle; van der Poel, Ma ...; Murthy, Hemant S ...; Liu, Hongtao; Mori, Shahram; De Oliveira, Sat ...; Bolanos-Meade, J ...; Elsawy, Mahmoud; Barba, Pere; Nathan, Sunita; George, Biju; Pawarode, Attaph ...; Grunwald, Michae ...; Agrawal, Vaibhav; Wang, Youjin; Assal, Amer; Caro, Paul Casti ...; Kuwatsuka, Yachi ...; Seo, Sachiko; Ustun, Celaletti ...; Politikos, Ioann ...; Lazarus, Hillard ...; Saber, Wael; Sandmaier, Brend ...; De Lima, Marcos; Litzow, Mark; Bachanova, Veron ...; Weisdorf, Daniel; show less...

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