Ultrasound-guided Percutaneous Irreversible Electroporation for Treatment of Locally Recurrent Pancreatic Cancer After Surgical Resection

Månsson, Christopher,Läkarexamen,1977-Uppsala universitet,Gastrointestinalkirurgi (author)

Background/Aim: Irreversible electroporation (IRE) has recently been used as an experimental treatment for cancers including locally advanced pancreatic cancer. There is very limited data on IRE in pancreatic cancer that is locally recurrent after surgical resection. The aim of this study was to evaluate the safety and efficacy of IRE in this setting.Patients and Methods: Ten patients with locally recurrent pancreatic cancer without distant metastases after surgical resection were included and treated with ultrasound-guided percutaneous IRE.Results: Two patients had severe complications, of whom one died. Median disease-free survival was 3.3 months and overall median survival after IRE and resection was 16.5 and 42.7 months, respectively. Two patients are alive 42.1 and 23.9 months after the IRE without signs of local recurrence.Conclusion: Percutaneous IRE in locally recurrent pancreatic cancer following curative resection is feasible, but should be regarded as a high-risk procedure that, at present, cannot be recommended outside of clinical trials. Further research is needed to select patients who might benefit from this treatment.

Nilsson, Anders,1958-Uppsala universitet,Radiologi(Swepub:uu)annil021 (author)
Nygren, PeterUppsala universitet,Experimentell och klinisk onkologi(Swepub:uu)peterng (author)
Karlson, Britt-MarieUppsala universitet,Gastrointestinalkirurgi(Swepub:uu)bmakarl (author)
Uppsala universitetGastrointestinalkirurgi (creator_code:org_t)

In:Anticancer Research: INT INST ANTICANCER RESEARCH40:5, s. 2771-27750250-70051791-7530

By the author/editor: Månsson, Christo ...; Nilsson, Anders, ...; Nygren, Peter; Karlson, Britt-M ...

About the subject

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Surgery

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Cancer and Oncol ...

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