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SSRI use during pre...
SSRI use during pregnancy and risk for postpartum haemorrhage : a national register-based cohort study in Sweden
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- Skalkidou, Alkistis, 1977- (author)
- Uppsala universitet,Obstetrisk och reproduktiv hälsoforskning
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- Sundström Poromaa, Inger, 1964- (author)
- Uppsala universitet,Institutionen för kvinnors och barns hälsa
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- Wikman, Anna (author)
- Uppsala universitet,Reproduktiv hälsa
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- Hesselman, Susanne, 1973- (author)
- Uppsala universitet,Klinisk obstetrik,Centrum för klinisk forskning Dalarna
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- Wikström, A K (author)
- Karolinska Institutet,Uppsala universitet,Institutionen för kvinnors och barns hälsa
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- Elenis, Evangelia, 1983- (author)
- Uppsala universitet,Reproduktiv hälsa
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(creator_code:org_t)
- 2020-04
- 2020
- English.
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In: British Journal of Obstetrics and Gynecology. - : John Wiley & Sons. - 1470-0328 .- 1471-0528. ; 127:11, s. 1366-1373
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
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- OBJECTIVE: Evaluate whether selective serotonin reuptake inhibitor (SSRI) use during pregnancy, as well as prior or current untreated psychiatric illness is associated with postpartum haemorrhage (PPH).DESIGN: National register-based cohort study based on data from the Swedish Pregnancy Register.SETTING: Sweden, nationwide coverage.POPULATION: A total of 31 159 pregnant women with singleton deliveries after gestational week 22+0 between January 2013 and July 2017.METHODS: Pregnant women with self-reported SSRI use at any time point during pregnancy were compared with non-SSRI-treated women with prior or current psychiatric illness, as well as wiith healthy women with no psychiatric illness or reporting SSRI use.MAIN OUTCOME MEASURES: Postpartum haemorrhage defined as blood loss >1000 ml during the first 2 hours postpartum reported by the delivering midwife or obstetrician.RESULTS: Postpartum haemorrhage prevalence was 7.0% among healthy women, 7.6% among women with prior or current psychiatric illness and 9.1% among women treated with SSRI. The unadjusted odds for PPH among women with prior or current psychiatric illness and women on SSRI treatment were increased by 9 and 34%, respectively, compared with healthy unmedicated women without a history of psychiatric illness (odds ratio [OR] 1.09, 95% CI 1.04-1.14 and OR 1.34, 95% CI 1.24-1.44, respectively). The estimates remained unchanged after adjustment for several confounders (such as maternal age, body mass index [BMI], parity, prior caesarean section, smoking, occupation and country of birth) and potential covariates (such as delivery mode, polyhydramnion, preterm delivery, labour dystocia and infant birthweight >4000 g).CONCLUSIONS: Higher risk for PPH was observed both among women treated with SSRI during pregnancy and among women with prior or current psychiatric illness.TWEETABLE ABSTRACT: SSRI use at any point during pregnancy and prior or current history of psychiatric illness was associated with an increased likelihood for PPH.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Reproduktionsmedicin och gynekologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Obstetrics, Gynaecology and Reproductive Medicine (hsv//eng)
Keyword
- Bleeding
- postpartum haemorrhage
- psychiatric illness
- selective serotonin reuptake inhibitor
Publication and Content Type
- ref (subject category)
- art (subject category)
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