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Survival following ...
Survival following allogeneic transplant in patients with myelofibrosis
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- Gowin, Krisstina (author)
- Univ Arizona, Div Hematol & Oncol, 3838 N Campbell Ave, Tucson, AZ 85719 USA.
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- Ballen, Karen (author)
- Univ Virginia Hlth Syst, Div Hematol & Oncol, Charlottesville, VA USA.
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- Ahn, Kwang Woo (author)
- Med Coll Wisconsin, Dept Med, Ctr Int Blood & Marrow Transplant Res, Milwaukee, WI 53226 USA.;Med Coll Wisconsin, Inst Hlth & Equ, Div Biostat, Milwaukee, WI 53226 USA.
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- Hu, Zhen-Huan (author)
- Med Coll Wisconsin, Dept Med, Ctr Int Blood & Marrow Transplant Res, Milwaukee, WI 53226 USA.
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- Ali, Haris (author)
- City Hope Natl Med Ctr, Duarte, CA USA.
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- Arcasoy, Murat O. (author)
- Duke Univ, Sch Med, Dept Med, Div Hematol, Durham, NC 27706 USA.
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- Devlin, Rebecca (author)
- Univ Hlth Network, Toronto, ON, Canada.
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- Coakley, Maria (author)
- Inst Canc Res, London, England.
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- Gerds, Aaron T. (author)
- Cleveland Clin, Taussig Canc Inst, Hematol & Med Oncol, Cleveland, OH 44106 USA.
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- Green, Michael (author)
- Duke Univ, Sch Med, Dept Med, Div Hematol, Durham, NC 27706 USA.
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- Gupta, Vikas (author)
- Univ Toronto, Princess Margaret Canc Ctr, Toronto, ON, Canada.
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- Hobbs, Gabriela (author)
- Massachusetts Gen Hosp, Boston, MA 02114 USA.
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- Jain, Tania (author)
- Mem Sloan Kettering Canc Ctr, 1275 York Ave, New York, NY 10021 USA.
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- Kandarpa, Malathi (author)
- Univ Michigan, Dept Internal Med, Ann Arbor, MI 48109 USA.
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- Komrokji, Rami (author)
- H Lee Moffitt Canc Ctr & Res Inst, Tampa, FL USA.
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- Kuykendall, Andrew T. (author)
- H Lee Moffitt Canc Ctr & Res Inst, Tampa, FL USA.
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- Luber, Kierstin (author)
- Washington Univ, Sch Med, Dept Osteopath Med, St Louis, MO USA.
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- Masarova, Lucia (author)
- MD Anderson Canc Ctr, Houston, TX USA.
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- Michaelis, Laura C. (author)
- Med Coll Wisconsin, Hematol & Med Oncol, Milwaukee, WI 53226 USA.
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- Patches, Sarah (author)
- Dana Farber Canc Inst, Boston, MA 02115 USA.
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- Pariser, Ashley C. (author)
- Northwestern Mem Hosp, Chicago, IL 60611 USA.
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- Rampal, Raajit (author)
- Mem Sloan Kettering Canc Ctr, 1275 York Ave, New York, NY 10021 USA.
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- Stein, Brady (author)
- Northwestern Mem Hosp, Chicago, IL 60611 USA.
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- Talpaz, Moshe (author)
- MD Anderson Canc Ctr, Houston, TX USA.
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- Verstovsek, Srdan (author)
- MD Anderson Canc Ctr, Houston, TX USA.
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- Wadleigh, Martha (author)
- Dana Farber Canc Inst, Boston, MA 02115 USA.
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- Agrawal, Vaibhav (author)
- Indiana Univ Sch Med, Div Hematol Oncol, Indianapolis, IN 46202 USA.
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- Aljurf, Mahmoud (author)
- King Faisal Specialist Hosp Ctr & Res, Dept Oncol, Riyadh, Saudi Arabia.
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- Angel Diaz, Miguel (author)
- Hosp Infantil Univ Nino Jesus, Dept Hematol Oncol, Madrid, Spain.
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- Avalos, Belinda R. (author)
- Carolinas HealthCare Syst, Dept Hematol Oncol & Blood Disorders, Levine Canc Inst, Atrium Hlth, Charlotte, NC USA.
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- Bacher, Ulrike (author)
- Univ Bern, Bern Univ Hosp, Dept Hematol, Inselspital, Bern, Switzerland.
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- Bashey, Asad (author)
- Northside Hosp, Blood & Marrow Transplant Program, Atlanta, GA USA.
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- Beitinjaneh, Amer M. (author)
- Univ Miami, Dept Med, Miami, FL USA.
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- Cerny, Jan (author)
- Univ Massachusetts, Med Ctr, Dept Med, Div Hematol Oncol, Worcester, MA USA.
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- Chhabra, Saurabh (author)
- Med Coll Wisconsin, Dept Med, Ctr Int Blood & Marrow Transplant Res, Milwaukee, WI 53226 USA.
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- Copelan, Edward (author)
- Carolinas HealthCare Syst, Levine Canc Inst, Atrium Hlth, Charlotte, NC USA.
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- Cutler, Corey S. (author)
- Dana Farber Canc Inst, Dept Med Oncol, Div Transplantat & Cellular Therapy, Boston, MA 02115 USA.
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- DeFilipp, Zachariah (author)
- Massachusetts Gen Hosp, Blood & Marrow Transplant Program, Boston, MA 02114 USA.
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- Gadalla, Shahinaz M. (author)
- NCI, Div Canc Epidemiol & Genet, Clin Genet Branch, NIH, Rockville, MD USA.
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- Ganguly, Siddhartha (author)
- Univ Kansas Hlth Syst, Div Hematol Malignancy & Cellular Therapeut, Kansas City, KS USA.
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- Grunwald, Michael R. (author)
- Carolinas HealthCare Syst, Dept Hematol Oncol & Blood Disorders, Levine Canc Inst, Atrium Hlth, Charlotte, NC USA.
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- Hashmi, Shahrukh K. (author)
- King Faisal Specialist Hosp Ctr & Res, Dept Oncol, Riyadh, Saudi Arabia.;Mayo Clin, Dept Internal Med, Rochester, MN USA.
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- Kharfan-Dabaja, Mohamed A. (author)
- Mayo Clin, Div Hematol Oncol, Blood & Marrow Transplantat Program, Jacksonville, FL 32224 USA.
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- Kindwall-Keller, Tamila (author)
- Univ Virginia Hlth Syst, Div Hematol & Oncol, Charlottesville, VA USA.
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- Kroeger, Nicolaus (author)
- Univ Hosp Hamburg, Dept Stem Cell Transplantat, Hamburg, Germany.
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- Lazarus, Hillard M. (author)
- Case Western Reserve Univ, Dept Med, Cleveland, OH 44106 USA.
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- Liesveld, Jane L. (author)
- Univ Rochester, Med Ctr, Dept Med, Rochester, NY 14642 USA.
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- Litzow, Mark R. (author)
- Mayo Clin Rochester, Div Hematol, Rochester, MN USA.;Mayo Clin Rochester, Transplant Ctr, Rochester, MN USA.
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- Marks, David, I (author)
- Univ Hosp Bristol NHS Trust, Adult Bone Marrow Transplant, Bristol, Avon, England.
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- Nathan, Sunita (author)
- Rush Univ, Med Ctr, Chicago, IL 60612 USA.
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- Nishihori, Taiga (author)
- H Lee Moffitt Canc Ctr & Res Inst, Dept Blood & Marrow Transplantat, Tampa, FL USA.
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- Olsson, Richard (author)
- Uppsala universitet,Centrum för klinisk forskning i Sörmland (CKFD),Karolinska Inst, Dept Lab Med, Stockholm, Sweden
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- Pawarode, Attaphol (author)
- Univ Michigan, Sch Med, Dept Internal Med, Blood & Marrow Transplantat Program,Div Hematol O, Ann Arbor, MI USA.
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- Rowe, Jacob M. (author)
- Shaare Zedek Med Ctr, Dept Hematol, Jerusalem, Israel.
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- Savani, Bipin N. (author)
- Vanderbilt Univ, Med Ctr, Dept Med, Div Hematol Oncol, Nashville, TN USA.
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- Savoie, Mary Lynn (author)
- Tom Baker Canc Clin, Calgary, AB, Canada.
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- Seo, Sachiko (author)
- Dokkyo Med Univ, Dept Haematol & Oncol, Mibu, Tochigi, Japan.
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- Solh, Melhem (author)
- Northside Hosp, Blood & Marrow Transplant Grp Georgia, Atlanta, GA USA.
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- Tamari, Roni (author)
- Mem Sloan Kettering Canc Ctr, 1275 York Ave, New York, NY 10021 USA.
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- Verdonck, Leo F. (author)
- Isala Clin, Dept Hematol Oncol, Zwolle, Netherlands.
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- Yared, Jean A. (author)
- Univ Maryland, Greenebaum Comprehens Canc Ctr, Dept Med, Div Hematol Oncol,Blood Marrow Transplantat Progr, Baltimore, MD 21201 USA.
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- Alyea, Edwin (author)
- Dana Farber Canc Inst, Ctr Hematol Oncol, Boston, MA 02115 USA.
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- Popat, Uday (author)
- MD Anderson Canc Ctr, Houston, TX USA.
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- Sobecks, Ronald (author)
- Cleveland Clin, Cleveland, OH 44106 USA.
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- Scott, Bart L. (author)
- Fred Hutchinson Canc Res Ctr, 1124 Columbia St, Seattle, WA 98104 USA.
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- Nakamura, Ryotaro (author)
- City Hope Natl Med Ctr, Dept Hematol & Hematopoiet Cell Transplantat, Duarte, CA USA.
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- Mesa, Ruben (author)
- UT Hlth San Antonio MD Anderson, San Antonio, TX USA.
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- Saber, Wael (author)
- Med Coll Wisconsin, Dept Med, Ctr Int Blood & Marrow Transplant Res, Milwaukee, WI 53226 USA.
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Univ Arizona, Div Hematol & Oncol, 3838 N Campbell Ave, Tucson, AZ 85719 USA Univ Virginia Hlth Syst, Div Hematol & Oncol, Charlottesville, VA USA. (creator_code:org_t)
- 2020-05-08
- 2020
- English.
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In: Blood Advances. - : AMER SOC HEMATOLOGY. - 2473-9529 .- 2473-9537. ; 4:9, s. 1965-1973
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
Close
- Allogeneic hematopoietic cell transplantation (HCT) is the only curative therapy for myelofibrosis (MF). In this large multicenter retrospective study, overall survival (OS) in MF patients treated with allogeneic HCT (551 patients) and without HCT (non-HCT) (1377 patients) was analyzed with Cox proportional hazards model. Survival analysis stratified by the Dynamic International Prognostic Scoring System (DIPSS) revealed that the first year of treatment arm assignment, due to upfront risk of transplant-related mortality (TRM), HCT was associated with inferior OS compared with non-HCT (non-HCT vs HCT: DIPSS intermediate 1 [Int-1]: hazard ratio [HR] = 0.26, P < .0001; DIPSS-Int-2 and higher: HR, 0.39, P < .0001). Similarly, in the DIPSS low-risk MF group, due to upfront TRM risk, OS was superior with non-HCT therapies compared with HCT in the first-year post treatment arm assignment (HR, 0.16, P = .006). However, after 1 year, OS was not significantly different (HR, 1.38, P = .451). Beyond 1 year of treatment arm assignment, an OS advantage with HCT therapy in Int-1 and higher DIPSS score patients was observed (non-HCT vs HCT: DIPSS-Int-1: HR, 2.64, P < .0001; DIPSS-Int-2 and higher: HR, 2.55, P < .0001). In conclusion, long-term OS advantage with HCT was observed for patients with Int-1 or higher risk MF, but at the cost of early TRM. The magnitude of OS benefit with HCT increased as DIPSS risk score increased and became apparent with longer follow-up.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Hematologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Hematology (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Gowin, Krisstina
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Ballen, Karen
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Ahn, Kwang Woo
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Hu, Zhen-Huan
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Ali, Haris
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Arcasoy, Murat O ...
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show more...
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Devlin, Rebecca
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Coakley, Maria
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Gerds, Aaron T.
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Green, Michael
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Gupta, Vikas
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Hobbs, Gabriela
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Jain, Tania
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Kandarpa, Malath ...
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Komrokji, Rami
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Kuykendall, Andr ...
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Luber, Kierstin
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Masarova, Lucia
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Michaelis, Laura ...
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Patches, Sarah
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Pariser, Ashley ...
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Rampal, Raajit
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Stein, Brady
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Talpaz, Moshe
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Verstovsek, Srda ...
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Wadleigh, Martha
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Agrawal, Vaibhav
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Aljurf, Mahmoud
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Angel Diaz, Migu ...
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Avalos, Belinda ...
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Bacher, Ulrike
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Bashey, Asad
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Beitinjaneh, Ame ...
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Cerny, Jan
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Chhabra, Saurabh
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Copelan, Edward
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Cutler, Corey S.
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DeFilipp, Zachar ...
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Gadalla, Shahina ...
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Ganguly, Siddhar ...
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Grunwald, Michae ...
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Hashmi, Shahrukh ...
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Kharfan-Dabaja, ...
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Kindwall-Keller, ...
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Kroeger, Nicolau ...
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Lazarus, Hillard ...
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Liesveld, Jane L ...
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Litzow, Mark R.
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Marks, David, I
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Nathan, Sunita
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Nishihori, Taiga
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Olsson, Richard
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Pawarode, Attaph ...
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Rowe, Jacob M.
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Savani, Bipin N.
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Savoie, Mary Lyn ...
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Seo, Sachiko
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Solh, Melhem
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Tamari, Roni
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Verdonck, Leo F.
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Yared, Jean A.
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Alyea, Edwin
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Popat, Uday
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Sobecks, Ronald
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Scott, Bart L.
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Nakamura, Ryotar ...
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Mesa, Ruben
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Saber, Wael
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Hematology
- Articles in the publication
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Blood Advances
- By the university
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Uppsala University
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Karolinska Institutet