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In Vitro Performanc...
In Vitro Performance and Chemical Stability of Lipid-Based Formulations Encapsulated in a Mesoporous Magnesium Carbonate Carrier
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- Alvebratt, Caroline (author)
- Uppsala universitet,Institutionen för farmaci
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Dening, Tahnee J (author)
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- Åhlén, Michelle (author)
- Uppsala universitet,Nanoteknologi och funktionella material
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- Cheung, Ocean (author)
- Uppsala universitet,Nanoteknologi och funktionella material
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- Strömme, Maria, 1970- (author)
- Uppsala universitet,Nanoteknologi och funktionella material
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- Gogoll, A, 1957- (author)
- Uppsala universitet,Organisk kemi,Uppsala University
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Prestidge, Clive A (author)
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- Bergström, Christel A. S., 1973- (author)
- Uppsala universitet,Institutionen för farmaci
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(creator_code:org_t)
- 2020-05-06
- 2020
- English.
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In: Pharmaceutics. - : MDPI AG. - 1999-4923. ; 12:5
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https://uu.diva-port... (primary) (Raw object)
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Abstract
Subject headings
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- Lipid-based formulations can circumvent the low aqueous solubility of problematic drug compounds and increase their oral absorption. As these formulations are often physically unstable and costly to manufacture, solidification has been suggested as a way to minimize these issues. This study evaluated the physicochemical stability and in vitro performance of lipid-loaded mesoporous magnesium carbonate (MMC) particles with an average pore size of 20 nm. A medium chain lipid was loaded onto the MMC carrier via physical adsorption. A modified in vitro lipolysis setup was then used to study lipid release and digestion with 1H nuclear magnetic resonance spectroscopy. The lipid loading efficiency with different solidification techniques was also evaluated. The MMC, unlike more commonly used porous silicate carriers, dissolved during the lipolysis assay, providing a rapid release of encapsulated lipids into solution. The digestion of the dispersed lipid-loaded MMC therefore resembled that of a coarse dispersion of the lipid. The stability data demonstrated minor degradation of the lipid within the pores of the MMC particles, but storage for three months did not reveal extensive degradation. To conclude, lipids can be adsorbed onto MMC, creating a solid powder from which the lipid is readily released into the solution during in vitro digestion. The chemical stability of the formulation does however merit further attention.
Subject headings
- TEKNIK OCH TEKNOLOGIER -- Nanoteknik (hsv//swe)
- ENGINEERING AND TECHNOLOGY -- Nano-technology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Farmaceutiska vetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Pharmaceutical Sciences (hsv//eng)
Keyword
- 1H nuclear magnetic resonance
- lipid release
- lipid-based formulations
- lipolysis
- mesoporous magnesium carbonate
- solidification
- Teknisk fysik med inriktning mot nanoteknologi och funktionella material
- Engineering Science with specialization in Nanotechnology and Functional Materials
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Alvebratt, Carol ...
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Dening, Tahnee J
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Åhlén, Michelle
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Cheung, Ocean
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Strömme, Maria, ...
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Gogoll, A, 1957-
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show more...
-
Prestidge, Clive ...
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Bergström, Chris ...
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show less...
- About the subject
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- ENGINEERING AND TECHNOLOGY
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ENGINEERING AND ...
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and Nano technology
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Pharmaceutical S ...
- Articles in the publication
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Pharmaceutics
- By the university
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Uppsala University