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Search: (WFRF:(Smith Eric A.)) srt2:(2020-2021) > Low-Dose Image-Guid...

  • Alcorn, Sara R.Johns Hopkins Univ Hosp, Baltimore, MD 21287 USA. (author)

Low-Dose Image-Guided Pediatric CNS Radiation Therapy : Final Analysis From a Prospective Low-Dose Cone-Beam CT Protocol From a Multinational Pediatrics Consortium

  • Article/chapterEnglish2020

Publisher, publication year, extent ...

  • 2020-04-24
  • SAGE PUBLICATIONS INC,2020
  • electronicrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:uu-414297
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-414297URI
  • https://doi.org/10.1177/1533033820920650DOI

Supplementary language notes

  • Language:English
  • Summary in:English

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Classification

  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Background: Lower-dose cone-beam computed tomography protocols for image-guided radiotherapy may permit target localization while minimizing radiation exposure. We prospectively evaluated a lower-dose cone-beam protocol for central nervous system image-guided radiotherapy across a multinational pediatrics consortium.Methods: Seven institutions prospectively employed a lower-dose cone-beam computed tomography central nervous system protocol (weighted average dose 0.7 mGy) for patients <= 21 years. Treatment table shifts between setup with surface lasers versus cone-beam computed tomography were used to approximate setup accuracy, and vector magnitudes for these shifts were calculated. Setup group mean, interpatient, interinstitution, and random error were estimated, and clinical factors were compared by mixed linear modeling.Results: Among 96 patients, with 2179 pretreatment cone-beam computed tomography acquisitions, median age was 9 years (1-20). Setup parameters were 3.13, 3.02, 1.64, and 1.48 mm for vector magnitude group mean, interpatient, interinstitution, and random error, respectively. On multivariable analysis, there were no significant differences in mean vector magnitude by age, gender, performance status, target location, extent of resection, chemotherapy, or steroid or anesthesia use. Providers rated >99% of images as adequate or better for target localization.Conclusions: A lower-dose cone-beam computed tomography protocol demonstrated table shift vector magnitude that approximate clinical target volume/planning target volume expansions used in central nervous system radiotherapy. There were no significant clinical predictors of setup accuracy identified, supporting use of this lower-dose cone-beam computed tomography protocol across a diverse pediatric population with brain tumors.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Zhou, Xian ChiongJohns Hopkins Bloomberg Sch Publ Hlth, Baltimore, MD USA. (author)
  • Bojechko, CaseyUniv Washington, Seattle, WA 98195 USA. (author)
  • Rubo, Rodrigo A.Ctr Infantil Boldrini, Sao Paulo, Brazil.;Ctr Infantil Boldrini, Regiao, Brazil. (author)
  • Chen, Michael J.Grp Apoio Ao Adolescente & Crianca Com Canc, Sao Paulo, Brazil. (author)
  • Dieckmann, KarinUniv Klin Strahlentherapie & Strahlenbiol, Vienna, Austria. (author)
  • Ermoian, Ralph P.Univ Washington, Seattle, WA 98195 USA. (author)
  • Ford, Eric C.Univ Washington, Seattle, WA 98195 USA. (author)
  • Kobyzeva, DariaFed Sci Clin Ctr Childrens Hematol Oncol & Immuno, Moscow, Russia. (author)
  • MacDonald, Shannon M.Massachusetts Gen Hosp, Boston, MA 02114 USA. (author)
  • McNutt, Todd R.Johns Hopkins Univ Hosp, Baltimore, MD 21287 USA. (author)
  • Nechesnyuk, AlexeyFed Sci Clin Ctr Childrens Hematol Oncol & Immuno, Moscow, Russia. (author)
  • Nilsson, Kristina,1967-Uppsala universitet,Experimentell och klinisk onkologi(Swepub:uu)kristnil (author)
  • Sjöstrand, HåkanUppsala Univ Hosp, Uppsala, Sweden. (author)
  • Smith, Koren S.Johns Hopkins Univ Hosp, Baltimore, MD 21287 USA. (author)
  • Stock, MarkusUniv Klin Strahlentherapie & Strahlenbiol, Vienna, Austria. (author)
  • Tryggestad, Erik J.Mayo Clin, Rochester, MN USA. (author)
  • Villar, Rosangela C.Ctr Infantil Boldrini, Sao Paulo, Brazil.;Ctr Infantil Boldrini, Regiao, Brazil. (author)
  • Winey, Brian A.Massachusetts Gen Hosp, Boston, MA 02114 USA. (author)
  • Terezakis, Stephanie A.Univ Minnesota, Dept Radiat Oncol & Mol Radiat Sci, 420 Delaware St, Minneapolis, MN 55455 USA. (author)
  • Johns Hopkins Univ Hosp, Baltimore, MD 21287 USA.Johns Hopkins Bloomberg Sch Publ Hlth, Baltimore, MD USA. (creator_code:org_t)

Related titles

  • In:Technology in Cancer Research & Treatment: SAGE PUBLICATIONS INC191533-03461533-0338

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