Search: WFRF:(Sarhadi Virinder) >
Gut Microbiota and ...
Gut Microbiota and Host Gene Mutations in Colorectal Cancer Patients and Controls of Iranian and Finnish Origin
-
- Sarhadi, Virinder (author)
- Univ Helsinki, Dept Pathol, Fac Med, FI-00014 Helsinki, Finland.
-
- Lahti, Leo (author)
- Univ Turku, Dept Future Technol, Turku, Finland.
-
- Saberi, Farideh (author)
- Isfahan Univ Med Sci, Sch Med, Dept Genet & Mol Biol, Esfahan, Iran.
-
show more...
-
- Youssef, Omar (author)
- Univ Helsinki, Dept Pathol, Fac Med, FI-00014 Helsinki, Finland.
-
- Kokkola, Arto (author)
- Univ Cent Hosp Helsinki, HUCH Gastrointestinal Clin, Helsinki, Finland.
-
- Karla, Tiina (author)
- Thermo Fisher Sci, Vantaa, Finland.
-
- Tikkanen, Milja (author)
- Thermo Fisher Sci, Vantaa, Finland.
-
- Rautelin, Hilpi (author)
- Uppsala universitet,Klinisk mikrobiologi
-
- Puolakkainen, Pauli (author)
- Thermo Fisher Sci, Vantaa, Finland.
-
- Salehi, Rasoul (author)
- Isfahan Univ Med Sci, Sch Med, Dept Genet & Mol Biol, Esfahan, Iran.;Isfahan Univ Med Sci, Pediat Inherited Dis Res Ctr, Esfahan, Iran.
-
- Knuutila, Sakari (author)
- Univ Helsinki, Dept Pathol, Fac Med, FI-00014 Helsinki, Finland.
-
show less...
-
Univ Helsinki, Dept Pathol, Fac Med, FI-00014 Helsinki, Finland Univ Turku, Dept Future Technol, Turku, Finland. (creator_code:org_t)
- 2020-03-04
- 2020
- English.
-
In: Anticancer Research. - : INT INST ANTICANCER RESEARCH. - 0250-7005 .- 1791-7530. ; 40:3, s. 1325-1334
- Related links:
-
https://helda.helsin...
-
show more...
-
https://urn.kb.se/re...
-
https://doi.org/10.2...
-
show less...
Abstract
Subject headings
Close
- Background/Aim: Gut microbiota plays an important role in colorectal cancer (CRC) and its composition in CRC patients can be influenced by ethnicity and tumour genomics. Herein, the aim was to study the possible associations of ethnicity and gene mutations with the gut microbiota in CRC patients.Materials and Methods: Bacterial composition in stool samples of 83 CRC patients and 60 controls from Iran and Finland was studied by 16S rRNA gene sequencing. The association of gut microbiota composition with CRC, host mutations in KRAS, NRAS and TP53, and ethnicity analysed.Results: Beta diversity analysis indicated significant differences between the Iranian and Finnish gut microbiota composition, in both controls and patients' groups. The Iranian controls had higher abundance of Prevotella and lower abundance of Bacteroides compared to the Finnish controls, while the Finnish patients had higher abundance of Clostridium compared to Iranian patients. Abundance of Ruminococcus was higher in patients compared to the controls. Higher abundances of Herbaspirillum, Catenibacterium and lower abundances of Barnesiella were associated with mutations in NRAS, TP53, and RAS respectively.Conclusion: A possible link of host gene mutations with gut bacterial composition is suggested.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Gastroenterologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Gastroenterology and Hepatology (hsv//eng)
Keyword
- Gut microbiota
- gene mutations
- colorectal cancer
- stool DNA
- 16S rRNA gene sequencing
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database
- By the author/editor
-
Sarhadi, Virinde ...
-
Lahti, Leo
-
Saberi, Farideh
-
Youssef, Omar
-
Kokkola, Arto
-
Karla, Tiina
-
show more...
-
Tikkanen, Milja
-
Rautelin, Hilpi
-
Puolakkainen, Pa ...
-
Salehi, Rasoul
-
Knuutila, Sakari
-
show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Clinical Medicin ...
-
and Cancer and Oncol ...
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Clinical Medicin ...
-
and Gastroenterology ...
- Articles in the publication
-
Anticancer Resea ...
- By the university
-
Uppsala University