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The Role of Donor L...
The Role of Donor Lymphocyte Infusion (DLI) in Post-Hematopoietic Cell Transplant (HCT) Relapse for Chronic Myeloid Leukemia (CML) in the Tyrosine Kinase Inhibitor (TKI) Era
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- Schmidt, Sarah (författare)
- Univ Oklahoma, Dept Hematol Oncol, 800 NE 10th St, Oklahoma City, OK 73104 USA.
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- Liu, Ying (författare)
- Med Coll Wisconsin, CIBMTR Ctr Int Blood & Marrow Transplant Res, Dept Med, Milwaukee, WI 53226 USA.;Med Coll Wisconsin, Inst Hlth & Equ, Div Biostat, Milwaukee, WI 53226 USA.
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- Hu, Zhen-Huan (författare)
- Med Coll Wisconsin, CIBMTR Ctr Int Blood & Marrow Transplant Res, Dept Med, Milwaukee, WI 53226 USA.
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- Williams, Kirsten M. (författare)
- Childrens Natl Hlth Syst, Childrens Res Inst, Washington, DC USA.
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- Lazarus, Hillard M. (författare)
- Case Western Reserve Univ, Cleveland, OH 44106 USA.
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- Vij, Ravi (författare)
- Washington Univ, Sch Med, Div Hematol & Oncol, St Louis, MO USA.
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- Kharfan-Dabaja, Mohamed A. (författare)
- Mayo Clin, Blood & Marrow Transplant Program, Divs Hematol Oncol, Jacksonville, FL 32224 USA.
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- Orti, Guillermo (författare)
- Vall dHebron Univ Hosp, Hematol Dept, Barcelona, Spain.
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- Wiernik, Peter H. (författare)
- Our Lady Mercy Med Ctr, Bronx, NY USA.
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- Weisdorf, Daniel (författare)
- Univ Minnesota, Dept Med, Med Ctr, Div Hematol Oncol & Transplantat, Box 736 UMHC, Minneapolis, MN 55455 USA.
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- Kamble, Rammurti T. (författare)
- Baylor Coll Med, Ctr Cell & Gene Therapy, Div Hematol & Oncol, Houston, TX 77030 USA.
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- Herzig, Roger (författare)
- Univ Kentucky, Markey Canc Ctr, Lexington, KY USA.
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- Wirk, Baldeep (författare)
- Seattle Canc Care Alliance, Div Bone Marrow Transplant, Seattle, WA USA.
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- Cerny, Jan (författare)
- Univ Massachusetts, Med Ctr, Dept Med, Div Hematol Oncol, Worcester, MA USA.
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- Bacher, Ulrike (författare)
- Bern Univ Hosp, Dept Hematol, Inselspital, Bern, Switzerland.
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- Chaudhri, Naeem A. (författare)
- King Faisal Specialist Hosp & Res Ctr, Dept Oncol, Riyadh, Saudi Arabia.
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- Nathan, Sunita (författare)
- Rush Univ, Med Ctr, Chicago, IL 60612 USA.
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- Farhadfar, Nosha (författare)
- Univ Florida, Coll Med, Dept Med, Div Hematol Oncol, Gainesville, FL USA.
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- Aljurf, Mahmoud (författare)
- King Faisal Specialist Hosp & Res Ctr, Dept Oncol, Riyadh, Saudi Arabia.
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- Gergis, Usama (författare)
- New York Presbyterian Hosp, Weill Cornell Med Ctr, Hematol Malignancies & Bone Marrow Transplant, Dept Med Oncol, New York, NY USA.
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- Szer, Jeffrey (författare)
- Peter MacCalluma Canc Ctr, Clin Hematol, Melbourne, Vic, Australia.;Royal Melbourne Hosp, Melbourne, Vic, Australia.
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- Seo, Sachiko (författare)
- Dokkyo Med Univ, Dept Hematol & Oncol, Mibu, Tochigi, Japan.
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- Hsu, Jack W. (författare)
- Rush Univ, Med Ctr, Chicago, IL 60612 USA.
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- Olsson, Richard (författare)
- Karolinska Institutet,Uppsala universitet,Centrum för klinisk forskning i Sörmland (CKFD),Karolinska Inst, Dept Lab Med, Stockholm, Sweden
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- Maharaj, Dipnarine (författare)
- South Florida Bone Marrow Stem Cell Transplant In, Boynton Beach, FL USA.
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- George, Biju (författare)
- Christian Med Coll & Hosp, Vellore, Tamil Nadu, India.
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- Hildebrandt, Gerhard C. (författare)
- Univ Kentucky, Markey Canc Ctr, Lexington, KY USA.
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- Agrawal, Vaibhav (författare)
- Indiana Univ Sch Med, Div Hematol Oncol, Indianapolis, IN 46202 USA.
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- Nishihori, Taiga (författare)
- H Lee Moffitt Canc Ctr & Res Inst, Dept Blood & Marrow Transplantat, Tampa, FL USA.
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- Abdel-Azim, Hisham (författare)
- Univ Southern Calif, Childrens Hosp Los Angeles, Keck Sch Med, Div Hematol Oncol & Blood Ea Marrow Transplantat, Los Angeles, CA 90007 USA.
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- Alyea, Edwin (författare)
- Dana Farber Canc Inst, Ctr Hematol Oncol, Boston, MA 02115 USA.
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- Popat, Uday (författare)
- MD Anderson Canc Ctr, Houston, TX USA.
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- Sobecks, Ronald (författare)
- Cleveland Clin Fdn, 9500 Euclid Ave, Cleveland, OH 44195 USA.
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- Scott, Bart L. (författare)
- Fred Hutchinson Canc Res Ctr, 1124 Columbia St, Seattle, WA 98104 USA.
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- Chakrabarty, Jennifer Holter (författare)
- Univ Oklahoma, Dept Hematol Oncol, 800 NE 10th St, Oklahoma City, OK 73104 USA.
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- Saber, Wael (författare)
- Med Coll Wisconsin, CIBMTR Ctr Int Blood & Marrow Transplant Res, Dept Med, Milwaukee, WI 53226 USA.
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Univ Oklahoma, Dept Hematol Oncol, 800 NE 10th St, Oklahoma City, OK 73104 USA Med Coll Wisconsin, CIBMTR Ctr Int Blood & Marrow Transplant Res, Dept Med, Milwaukee, WI 53226 USA.;Med Coll Wisconsin, Inst Hlth & Equ, Div Biostat, Milwaukee, WI 53226 USA. (creator_code:org_t)
- Elsevier BV, 2020
- 2020
- Engelska.
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Ingår i: Biology of blood and marrow transplantation. - : Elsevier BV. - 1083-8791 .- 1523-6536. ; 26:6, s. 1137-1143
- Relaterad länk:
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http://www.astctjour...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- Treatment for relapse of chronic myeloid leukemia (CML) following hematopoietic cell transplantation (HCT) includes tyrosine kinase inhibitors (TKIs) with or without donor lymphocyte infusions (DLIs), but the most effective treatment strategy is unknown. This study was performed through the Center for International Blood and Marrow Transplant Research (CIBMTR) database. We retrospectively reviewed all patients reported to the CIBMTR registry from 2002 to 2014 who underwent HCT for CML and were alive 30 days postrelapse. A total of 215 HCT recipients relapsed and were analyzed in the following groups: (1) TKI alone (n = 128), (2) TKI with DLI (n = 48), and (3) DLI without TKI (n = 39). In multivariate analysis, disease status prior to HCT had a significant effect on overall survival (OS). Patients who received a DLI alone compared with a TKI with a DLI had inferior survival (hazard ratio, 2.28; 95% confidence interval, 1.23 to 4.24; P= .009). Those who received a TKI alone had similar survival compared with those who received a TKI with a DLI (P = .81). These data support that despite use of TKIs pretransplantation, TKI salvage therapy continues to provide significant survival following relapse in patients with CML following HCT. These data do not suggest that adding a DLI to a TKI adds an improvement in OS.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Hematologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Hematology (hsv//eng)
Nyckelord
- Chronic myeloid leukemia
- Hematopoietic cell transplantation
- Tyrosine kinase inhibitor
- Donor lymphocyte infusion
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Till lärosätets databas
- Av författaren/redakt...
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Schmidt, Sarah
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Liu, Ying
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Hu, Zhen-Huan
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Williams, Kirste ...
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Lazarus, Hillard ...
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Vij, Ravi
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visa fler...
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Kharfan-Dabaja, ...
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Orti, Guillermo
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Wiernik, Peter H ...
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Weisdorf, Daniel
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Kamble, Rammurti ...
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Herzig, Roger
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Wirk, Baldeep
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Cerny, Jan
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Bacher, Ulrike
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Chaudhri, Naeem ...
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Nathan, Sunita
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Farhadfar, Nosha
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Aljurf, Mahmoud
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Gergis, Usama
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Szer, Jeffrey
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Seo, Sachiko
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Hsu, Jack W.
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Olsson, Richard
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Maharaj, Dipnari ...
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George, Biju
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Hildebrandt, Ger ...
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Agrawal, Vaibhav
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Nishihori, Taiga
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Abdel-Azim, Hish ...
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Alyea, Edwin
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Popat, Uday
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Sobecks, Ronald
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Scott, Bart L.
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Chakrabarty, Jen ...
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Saber, Wael
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Hematologi
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Biology of blood ...
- Av lärosätet
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Uppsala universitet
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Karolinska Institutet