On Acute Thrombo-Embolic Occlusion of the Superior Mesenteric Artery

↓ Direkt till sidans innehåll
↓ Direkt till sidans sekundära innehåll (sidomenyn)

Sökning: (db:Swepub) lar1:(uu) srt2:(2000-2004) mspu:(doctoralthesis) > (2004) > On Acute Thrombo-Em...

Acosta, Stefan,1967-Uppsala universitet,Institutionen för kirurgiska vetenskaper (författare)

On Acute Thrombo-Embolic Occlusion of the Superior Mesenteric Artery

BokEngelska2004

Förlag, utgivningsår, omfång ...

Uppsala :Acta Universitatis Upsaliensis,2004
67 s.
electronicrdacarrier

Nummerbeteckningar

LIBRIS-ID:oai:DiVA.org:uu-4147
ISBN:9155459269
https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-4147URI

Kompletterande språkuppgifter

Språk:engelska
Sammanfattning på:engelska

Ingår i deldatabas

SwePubSwePub

Klassifikation

Ämneskategori:vet swepub-contenttype
Ämneskategori:dok swepub-publicationtype

Serie

Comprehensive Summaries of Uppsala Dissertations from the Faculty of Medicine,0282-7476 ;1337

Anmärkningar

Acute thrombo-embolic occlusion of the superior mesenteric artery (SMA) with intestinal infarction is a lethal disease, difficult to diagnose in time, with unknown incidence and cause-specific mortality. The aim of this thesis was to characterize the disease and to develop diagnostic methods. Two laboratory studies were conducted on patients with suspected acute SMA occlusion. A pilot-study showed that the fibrinolytic marker D-dimer was elevated in six patients with the disease. In the subsequent study including 101 patients, D-dimer was the only elevated coagulation marker in nine patients with the disease. In a prospective study 24 patients (median age 84 years) were identified, of whom four were diagnosed at autopsy, despite an autopsy-rate of 10%. One-fourth were initially nursed in non-surgical wards. Length of the intestinal infarction was a predictor for death. An analysis of patients from the three studies showed that D-Dimer was elevated in all 16 tested patients with the disease.Sixty patients with acute SMA occlusion underwent intestinal revascularisation and were registered in the Swedish Vascular Registry (SWEDVASC). One-year survival-rate was 40%. Previous vascular surgery was a negative risk-factor.A population-based study was conducted in Malmö, based on an autopsy-rate of 87%. Among 270 patients with the disease, 2/3 were diagnosed only at autopsy and 1/2 were managed in non-surgical wards. The incidence was 8.6 per 100000 person years. The age-standardized incidence increased exponentially without gender differences. The diagnosis was the cause of death in 1.2% among octogenarians and beyond. Thrombotic occlusions were located proximally within the SMA and associated with extensive intestinal infarctions. Synchronous embolism, often multiple, occurred in 2/3 of the patients with embolic occlusions.Conclusions: A normal D-dimer at presentation most likely excludes the diagnosis. Acute SMA occlusion was more frequent than previously estimated from clinical series. The patients were often nursed in non-surgical wards.

Ämnesord och genrebeteckningar

MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Kirurgi hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Surgery hsv//eng
Surgery
acute thrombo-embolic occlusion
superior mesenteric artery
intestinal infarction
D-Dimer
intestinal revascularisation
population-based study
incidence
autopsy
Kirurgi
Surgery
Kirurgi

Biuppslag (personer, institutioner, konferenser, titlar ...)

Björck, Martin (preses)
Ögren, Mats (preses)
Lindblad, Bengt,DocentInstitutionen för kirurgi, Malmö (opponent)
Uppsala universitetInstitutionen för kirurgiska vetenskaper (creator_code:org_t)

Internetlänk

Hitta via bibliotek

On Acute Thrombo-Embolic Occlusion of the Superior Mesenteric Artery (Sök publikationen i LIBRIS)

Till lärosätets databas

Hitta mer i SwePub

Av författaren/redakt...: Acosta, Stefan, ...; Björck, Martin; Ögren, Mats; Lindblad, Bengt, ...

Om ämnet

MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Klinisk medicin; och Kirurgi

Delar i serien: Comprehensive Su ...

Av lärosätet: Uppsala universitet

Sök utanför SwePub

Sök vidare i:: Google; Google Book Search; Google Scholar

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

LIBRIS.kb.se