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Ancient human genome sequence of an extinct Palaeo-Eskimo

Rasmussen, Morten (author)
Li, Yingrui (author)
Lindgreen, Stinus (author)
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Pedersen, Jakob Skou (author)
Albrechtsen, Anders (author)
Moltke, Ida (author)
Metspalu, Mait (author)
Metspalu, Ene (author)
Kivisild, Toomas (author)
Gupta, Ramneek (author)
Bertalan, Marcelo (author)
Nielsen, Kasper (author)
Gilbert, M. Thomas P. (author)
Wang, Yong (author)
Raghavan, Maanasa (author)
Campos, Paula F. (author)
Kamp, Hanne Munkholm (author)
Wilson, Andrew S. (author)
Gledhill, Andrew (author)
Tridico, Silvana (author)
Bunce, Michael (author)
Lorenzen, Eline D. (author)
Binladen, Jonas (author)
Guo, Xiaosen (author)
Zhao, Jing (author)
Zhang, Xiuqing (author)
Zhang, Hao (author)
Li, Zhuo (author)
Villems, Richard (author)
Uppsala universitet,Kollegiet för avancerade studier (SCAS)
Chen, Minfeng (author)
Orlando, Ludovic (author)
Kristiansen, Karsten (author)
Bak, Mads (author)
Tommerup, Niels (author)
Bendixen, Christian (author)
Pierre, Tracey L. (author)
Grønnow, Bjarne (author)
Meldgaard, Morten (author)
Andreasen, Claus (author)
Fedorova, Sardana A. (author)
Osipova, Ludmila P. (author)
Higham, Thomas F. G. (author)
Ramsey, Christopher Bronk (author)
Hansen, Thomas v. O. (author)
Nielsen, Finn C. (author)
Crawford, Michael H. (author)
Brunak, Søren (author)
Sicheritz-Pontén, Thomas (author)
Nielsen, Rasmus (author)
Krogh, Anders (author)
Wang, Jun (author)
Willerslev, Eske (author)
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 (creator_code:org_t)
Springer Science and Business Media LLC, 2010
2010
English.
In: Nature. - : Springer Science and Business Media LLC. - 0028-0836 .- 1476-4687. ; 463:7282, s. 757-762
Related links:
https://doi.org/10.1...
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https://urn.kb.se/re...
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  • Journal article (peer-reviewed)
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  • We report here the genome sequence of an ancient human. Obtained from ∼4,000-year-old permafrost-preserved hair, the genome represents a male individual from the first known culture to settle in Greenland. Sequenced to an average depth of 20×, we recover 79% of the diploid genome, an amount close to the practical limit of current sequencing technologies. We identify 353,151 high-confidence single-nucleotide polymorphisms (SNPs), of which 6.8% have not been reported previously. We estimate raw read contamination to be no higher than 0.8%. We use functional SNP assessment to assign possible phenotypic characteristics of the individual that belonged to a culture whose location has yielded only trace human remains. We compare the high-confidence SNPs to those of contemporary populations to find the populations most closely related to the individual. This provides evidence for a migration from Siberia into the New World some 5,500 years ago, independent of that giving rise to the modern Native Americans and Inuit.

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