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The promise, percep...
The promise, perceptions, and pitfalls of immunoassays for autoantibody testing in myositis
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- Tansley, Sarah L. (författare)
- Univ Bath, Bath, Avon, England.
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- Snowball, Julia (författare)
- Univ Bath, Bath, Avon, England.
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- Pauling, John D. (författare)
- Univ Bath, Bath, Avon, England.
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visa fler...
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- Lissina, Anya (författare)
- Univ Bath, Bath, Avon, England.
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- Kuwana, Masataka (författare)
- Keio Univ, Tokyo, Japan.
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- Rider, Lisa G. (författare)
- NIH, Bldg 10, Bethesda, MD 20892 USA.
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- Rönnelid, Johan (författare)
- Uppsala universitet,Klinisk immunologi
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- McHugh, Neil J. (författare)
- Univ Bath, Bath, Avon, England.
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Univ Bath, Bath, Avon, England Keio Univ, Tokyo, Japan. (creator_code:org_t)
- 2020-05-15
- 2020
- Engelska.
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Ingår i: Arthritis Research & Therapy. - : BMC. - 1478-6362. ; 22:1
- Relaterad länk:
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https://doi.org/10.1...
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https://uu.diva-port... (primary) (Raw object)
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https://arthritis-re...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Background A myositis-specific autoantibody can now be identified in the majority of patients with myositis. They identify homogeneous patient subgroups and are key tools in developing a personalized approach to disease management. There is substantial clinical interest in exploiting myositis autoantibodies as biomarkers, and consequently, a large number of commercial assays have been developed for their detection. These assays are already in widespread clinical use. In order to better understand perceived concerns from the international myositis community in relation to the reliability of these assays and how they are being used, we conducted a survey of international myositis experts, all of whom were members of the International Myositis Assessment and Clinical Studies group. Results We collected data on the types of assay used, manufacturers, and the nature of the report provided by different laboratories and received 111 complete responses. Respondents also provided information on how they used the different assays, their confidence in the results, and how this influenced their clinical practice. Enzyme immunoassay/ELISA was the most popular assay method used worldwide followed by line blot. Line blot was the most popular method used in Europe. Despite concerns from over 80% of respondents regarding false-positive and false-negative results with the assay used by their laboratory, over 80% reported that the identification of a myositis autoantibody influenced their diagnostic confidence, the information they provided to a patient, and their recommended treatment. Conclusions In spite of ongoing concerns from the majority of users regarding the reliability of the results, myositis-specific autoantibody testing, using commercial immunoassays, is being used globally to inform clinical decision-making. These findings highlight the need for urgent guidance on the use of myositis autoantibody testing and on the interpretation of results. Knowledge of the reliability of currently available assays is essential given the importance already placed on myositis-specific autoantibodies as clinical decision-making tools.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Reumatologi och inflammation (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Rheumatology and Autoimmunity (hsv//eng)
Nyckelord
- Myositis
- Autoantibody
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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