Sökning: WFRF:(Engstrand Lilja Helene 1963 ) >
Total colonic agang...
Total colonic aganglionosis: : a multicenter study of surgical treatment and patient-reported outcomes up to adulthood
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Stenström, Pernilla (författare)
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Kyrklund, Kristiina (författare)
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Bräutigam, Matilda (författare)
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visa fler...
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- Engstrand Lilja, Helene, 1963- (författare)
- Uppsala universitet,Barnkirurgisk forskning,Barnkirurgi
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Stensrud, Kjetil Juul (författare)
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- Löf Granström, Anna (författare)
- Karolinska Institutet
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Qvist, Niels (författare)
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Söndergaard Johansson, Lars (författare)
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Arnbjörnsson, Einar (författare)
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Borg, Helene (författare)
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- Wester, Tomas (författare)
- Karolinska Institutet
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Björnland, Kristin (författare)
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Pakarinen, Mikko P. (författare)
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visa färre...
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(creator_code:org_t)
- 2020-07-13
- 2020
- Engelska.
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Ingår i: BJS Open. - : Oxford University Press (OUP). - 2474-9842. ; 4:5, s. 943-953
- Relaterad länk:
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https://doi.org/10.1...
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https://uu.diva-port... (primary) (Raw object)
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https://academic.oup...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- Background: Surgery for total colonic aganglionosis (TCA) is designed to preserve continence and achieve satisfactory quality of life. This study evaluated a comprehensive group of clinical and social outcomes.Methods: An international multicentre study from eight Nordic hospitals involving examination of case records and a patient-reported questionnaire survey of all patients born with TCA between 1987 and 2006 was undertaken.Results: Of a total of 116 patients, five (4 center dot 3 per cent) had died and 102 were traced. Over a median follow-up of 12 (range 0 center dot 3-33) years, bowel continuity was established in 75 (73 center dot 5 per cent) at a median age of 11 (0 center dot 5-156) months. Mucosectomy with a short muscular cuff and straight ileoanal anastomosis (SIAA) (29 patients) or with aJpouch (JIAA) (26) were the most common reconstructions (55 of 72, 76 per cent). Major early postoperative complications requiring surgical intervention were observed in four (6 per cent) of the 72 patients. In 57 children aged over 4 years, long-term functional bowel symptoms after reconstruction included difficulties in holding back defaecation in 22 (39 per cent), more than one faecal accident per week in nine (16 per cent), increased frequency of defaecation in 51 (89 per cent), and social restrictions due to bowel symptoms in 35 (61 per cent). Enterocolitis occurred in 35 (47 per cent) of 72 patients. Supplementary enteral and/or parenteral nutrition was required by 51 (55 per cent) of 93 patients at any time during follow-up. Of 56 responders aged 2-20 years, true low BMI for age was found in 20 (36 per cent) and 13 (23 per cent) were short for age.Conclusion: Reconstruction for TCA was associated with persistent bowel symptoms, and enterocolitis remained common. Multidisciplinary follow-up, including continuity of care in adulthood, might improve care standards in patients with TCA.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kirurgi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Surgery (hsv//eng)
Nyckelord
- Pediatric Surgery
- Barnkirurgi
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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- Av författaren/redakt...
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Stenström, Perni ...
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Kyrklund, Kristi ...
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Bräutigam, Matil ...
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Engstrand Lilja, ...
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Stensrud, Kjetil ...
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Löf Granström, A ...
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visa fler...
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Qvist, Niels
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Söndergaard Joha ...
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Arnbjörnsson, Ei ...
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Borg, Helene
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Wester, Tomas
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Björnland, Krist ...
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Pakarinen, Mikko ...
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visa färre...
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Kirurgi
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BJS Open
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Uppsala universitet
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Karolinska Institutet