Sökning: WFRF:(Kolmos Hans Jørn) >
Prognostic value of...
Prognostic value of 12 novel cardiological biomarkers in stable coronary artery disease : A 10-year follow-up of the placebo group of the Copenhagen CLARICOR trial
-
- Winkel, Per (författare)
- The Copenhagen Trial Unit, Centre for Clinical Intervention Research, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark
-
- Jakobsen, Janus Christian (författare)
- The Copenhagen Trial Unit, Centre for Clinical Intervention Research, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark; Department of Regional Health Research, The Faculty of Heath Sciences, University of Southern Denmark, Copenhagen, Denmark
-
- Hilden, Jørgen (författare)
- Section of Biostatistics, Department of Public Health Research, University of Copenhagen, Copenhagen, Denmark
-
visa fler...
-
- Jensen, Gorm Boje (författare)
- Department of Cardiology, Hvidovre Hospital, Copenhagen University Hospital, Copenhagen, Denmark
-
- Kjøller, Erik (författare)
- Cardiology, Herlev and Gentofte Hospital, Herlev, Denmark
-
- Sajadieh, Ahmad (författare)
- Department of Cardiology, Bispebjerg Hospital, Copenhagen University Hospital, Copenhagen, Denmark
-
- Kastrup, Jens (författare)
- Rigshopitalet, University of Copenhagen, Copenhagen, Denmark
-
- Kolmos, Hans Jørn (författare)
- Department of Clinical Microbiology, Odense University Hospital, Copenhagen, Denmark
-
- Karmark Iversen, Kasper (författare)
- Department of Cardiology, Herlev Hospital, Copenhagen University Hospital, Herlev, Denmark
-
- Bjerre, Mette (författare)
- The Medical Research Laboratory, Department of Clinical Medicine, Aarhus University, Aarhus, Denmark
-
- Larsson, Anders (författare)
- Uppsala universitet,Klinisk kemi
-
- Ärnlöv, Johan (författare)
- Karolinska Institutet
-
- Gluud, Christian (författare)
- The Copenhagen Trial Unit, Centre for Clinical Intervention Research, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark
-
visa färre...
-
(creator_code:org_t)
- 2020-08-20
- 2020
- Engelska.
-
Ingår i: BMJ Open. - : BMJ. - 2044-6055. ; 10:8
- Relaterad länk:
-
https://doi.org/10.1...
-
visa fler...
-
https://uu.diva-port... (primary) (Raw object)
-
https://bmjopen.bmj....
-
https://urn.kb.se/re...
-
https://doi.org/10.1...
-
http://kipublication...
-
visa färre...
Abstract
Ämnesord
Stäng
- OBJECTIVE: To assess if 12 novel circulating biomarkers, when added to 'standard predictors' available in general practice, could improve the 10-year prediction of cardiovascular events and mortality in patients with stable coronary heart disease.DESIGN: The patients participated as placebo receiving patients in the randomised clarithromycin for patients with stable coronary artery disease (CLARICOR) trial at a random time in their disease trajectory.SETTING: Five Copenhagen University cardiology departments and a coordinating centre.PARTICIPANTS: 1998 participants with stable coronary artery disease.OUTCOMES: Death and composite of myocardial infarction, unstable angina pectoris, cerebrovascular disease and death.RESULTS: When only 'standard predictors' were included, 83.4% of all-cause death predictions and 68.4% of composite outcome predictions were correct. Log(calprotectin) and log(cathepsin-S) were not associated (p≥0.01) with the outcomes, not even as single predictors. Adding the remaining 10 biomarkers (high-sensitive assay cardiac troponin T; neutrophil gelatinase-associated lipocalin; osteoprotegerin; N-terminal pro-B-type natriuretic peptide; tumour necrosis factor receptor 1 and 2; pregnancy-associated plasma protein A; endostatin; YKL40; cathepsin-B), which were all individually significantly associated with the prediction of the two outcomes, increased the figures to 84.7% and 69.7%.CONCLUSION: When 'standard predictors' routinely available in general practices are used for risk assessment in consecutively sampled patients with stable coronary artery disease, the addition of 10 novel biomarkers to the prediction model improved the correct prediction of all-cause death and the composite outcome by <1.5%.TRIAL REGISTRATION NUMBER: NCT00121550.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
Nyckelord
- biomarker
- cardiology
- coronary heart disease
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
-
BMJ Open
(Sök värdpublikationen i LIBRIS)
Till lärosätets databas
- Av författaren/redakt...
-
Winkel, Per
-
Jakobsen, Janus ...
-
Hilden, Jørgen
-
Jensen, Gorm Boj ...
-
Kjøller, Erik
-
Sajadieh, Ahmad
-
visa fler...
-
Kastrup, Jens
-
Kolmos, Hans Jør ...
-
Karmark Iversen, ...
-
Bjerre, Mette
-
Larsson, Anders
-
Ärnlöv, Johan
-
Gluud, Christian
-
visa färre...
- Om ämnet
-
- MEDICIN OCH HÄLSOVETENSKAP
-
MEDICIN OCH HÄLS ...
-
och Klinisk medicin
-
och Kardiologi
- Artiklar i publikationen
-
BMJ Open
- Av lärosätet
-
Uppsala universitet
-
Karolinska Institutet