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Diagnostic Accuracy...
Diagnostic Accuracy of [11C]PIB Positron Emission Tomography for Detection of Cardiac Amyloidosis
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- Rosengren, Sara (author)
- Uppsala universitet,Hematologi
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Skibsted Clemmensen, Tor (author)
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Tolbod, Lars (author)
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- Granstam, Sven-Olof, 1963- (author)
- Uppsala universitet,Klinisk fysiologi
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Eiskjær, Hans (author)
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- Wikström, Gerhard (author)
- Uppsala universitet,Kardiologi
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- Vedin, Ola (author)
- Uppsala universitet,Kardiologi
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- Kero, Tanja (author)
- Uppsala universitet,Radiologi
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- Lubberink, Mark (author)
- Uppsala universitet,Radiologi,Institutionen för immunologi, genetik och patologi
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Harms, Hendrik J (author)
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- Flachskampf, Frank A, 1957- (author)
- Uppsala universitet,Klinisk fysiologi
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- Baron, Tomasz (author)
- Uppsala universitet,Klinisk fysiologi
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- Carlson, Kristina (author)
- Uppsala universitet,Hematologi
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Mikkelsen, Fabian (author)
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- Antoni, Gunnar (author)
- Uppsala universitet,Preparativ läkemedelskemi
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Frost Andersen, Niels (author)
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Hvitfeldt Poulsen, Steen (author)
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- Sörensen, Jens (author)
- Uppsala universitet,Radiologi
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(creator_code:org_t)
- Elsevier BV, 2020
- 2020
- English.
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In: JACC Cardiovascular Imaging. - : Elsevier BV. - 1936-878X .- 1876-7591. ; 13:6, s. 1337-1347
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https://doi.org/10.1...
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https://urn.kb.se/re...
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Abstract
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- OBJECTIVES: This dual-site study evaluated the diagnostic accuracy of the method.BACKGROUND: Pittsburgh compound ([11C]PIB) positron emission tomography (PIB-PET) has shown promise as a specific and noninvasive method for the diagnosis of cardiac amyloidosis (CA).METHODS: The study had 2 parts. In the initial study, 51 subjects were included, 36 patients with known CA and increased wall thickness (15 immunoglobulin light chain [AL] and 21 transthyretin [ATTR] amyloidosis) and 15 control patients (7 were nonamyloid hypertrophic and 8 healthy volunteers). Subjects underwent PIB-PET and echocardiography. Sensitivity and specificity of PIB-PET were established for 2 simple semiquantitative approaches, standardized uptake value ratio (SUVR) and retention index (RI). The second part of the study included 11 amyloidosis patients (5 AL and 6 hereditary ATTR) without increased wall thickness to which the optimal cutoff values of SUVR (>1.09) and RI (>0.037 min-1) were applied prospectively.RESULTS: The diagnostic accuracy of visual inspection of [11C]PIB uptake was 100% in discriminating CA patients with increased wall thickness from controls. Semiquantitative [11C]PIB uptake discriminated CA from controls with a 94% (95% confidence interval [CI]: 80% to 99%) sensitivity for both SUVR and RI and specificity of 93% (95% CI: 66% to 100%) for SUVR and 100% (95% CI: 75% to 100%) for RI. [11C]PIB uptake was significantly higher in AL-CA than in ATTR-CA patients (p < 0.001) and discriminated AL-CA from controls with 100% (95% CI: 88% to 100%) accuracy for both the semiquantitative measures. In the prospective group without increased wall thickness, RI was elevated compared to controls (p = 0.001) and 5 of 11 subjects were evaluated as [11C]PIB PET positive.CONCLUSIONS: In a dual-center setting, [11C]PIB PET was highly accurate in detecting cardiac involvement in the main amyloid subtypes, with 100% accuracy in AL amyloidosis. A proportion of amyloidosis patients without known cardiac involvement were [11C]PIB PET positive, indicating that the method may detect early stages of CA.
Keyword
- PET
- Pittsburgh compound B
- diagnosis
- heart
- nuclear imaging
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Rosengren, Sara
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Skibsted Clemmen ...
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Tolbod, Lars
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Granstam, Sven-O ...
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Eiskjær, Hans
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Wikström, Gerhar ...
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show more...
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Vedin, Ola
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Kero, Tanja
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Lubberink, Mark
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Harms, Hendrik J
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Flachskampf, Fra ...
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Baron, Tomasz
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Carlson, Kristin ...
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Mikkelsen, Fabia ...
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Antoni, Gunnar
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Frost Andersen, ...
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Hvitfeldt Poulse ...
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Sörensen, Jens
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JACC Cardiovascu ...
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Uppsala University