Risk Factors for Graft-versus-Host Disease in Haploidentical Hematopoietic Cell Transplantation Using Post-Transplant Cyclophosphamide

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Im, AnnieUniv Pittsburgh, UPMC, Hillman Canc Ctr, Pittsburgh, PA USA. (author)

Risk Factors for Graft-versus-Host Disease in Haploidentical Hematopoietic Cell Transplantation Using Post-Transplant Cyclophosphamide

Article/chapterEnglish2020

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Elsevier BV,2020
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LIBRIS-ID:oai:DiVA.org:uu-419189
https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-419189URI
https://doi.org/10.1016/j.bbmt.2020.05.001DOI
http://kipublications.ki.se/Default.aspx?queryparsed=id:144217400URI

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Language:English
Summary in:English

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SwePubSwePub

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Subject category:ref swepub-contenttype
Subject category:art swepub-publicationtype

Notes

Post-transplant cyclophosphamide (PTCy) has significantly increased the successful use of haploidentical donors with a relatively low incidence of graft-versus-host disease (GVHD). Given its increasing use, we sought to determine risk factors for GVHD after haploidentical hematopoietic cell transplantation (haplo-HCT) using PTCy. Data from the Center for International Blood and Marrow Transplant Research on adult patients with acute myeloid leukemia, acute lymphoblastic leukemia, myelodysplastic syndrome, or chronic myeloid leukemia who underwent PTCy-based haplo-HCT (2013 to 2016) were analyzed and categorized into 4 groups based on myeloablative (MA) or reduced-intensity conditioning (RIC) and bone marrow (BM) or peripheral blood (PB) graft source. In total, 646 patients were identified (MA-BM = 79, MA-PB = 183, RIC-BM = 192, RIC-PB = 192). The incidence of grade 2 to 4 acute GVHD at 6 months was highest in MA-PB (44%), followed by RIC-PB (36%), MA-BM (36%), and RIC-BM (30%) (P = .002). The incidence of chronic GVHD at 1 year was 40%, 34%, 24%, and 20%, respectively (P < .001). In multivariable analysis, there was no impact of stem cell source or conditioning regimen on grade 2 to 4 acute GVHD; however, older donor age (30 to 49 versus <29 years) was significantly associated with higher rates of grade 2 to 4 acute GVHD (hazard ratio [HR], 1.53; 95% confidence interval [CI], 1.11 to 2.12; P = .01). In contrast, PB compared to BM as a stem cell source was a significant risk factor for the development of chronic GVHD (HR, 1.70; 95% CI, 1.11 to 2.62; P = .01) in the RIC setting. There were no differences in relapse or overall survival between groups. Donor age and graft source are risk factors for acute and chronic GVHD, respectively, after PTCy-based haplo-HCT. Our results indicate that in RIC haplo-HCT, the risk of chronic GVHD is higher with PB stem cells, without any difference in relapse or overall survival.

Subject headings and genre

MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Hematologi hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Hematology hsv//eng

Added entries (persons, corporate bodies, meetings, titles ...)

Rashidi, ArminUniv Minnesota, Dept Med, Div Hematol Oncol & Transplantat, Box 736 UMHC, Minneapolis, MN 55455 USA. (author)
Wang, TaoMed Coll Wisconsin, Dept Med, CIBMTR, Milwaukee, WI 53226 USA.;Med Coll Wisconsin, Inst Hlth & Equ, Div Biostat, Milwaukee, WI 53226 USA. (author)
Hemmer, MichaelMed Coll Wisconsin, Dept Med, CIBMTR, Milwaukee, WI 53226 USA. (author)
MacMillan, Margaret L.Univ Minnesota, Dept Pediat, Blood & Marrow Transplant Program, Minneapolis, MN 55455 USA. (author)
Pidala, JosephH Lee Moffitt Canc Ctr & Res Inst, Tampa, FL USA. (author)
Jagasia, MadanVanderbilt Univ, Med Ctr, Nashville, TN USA. (author)
Pavletic, StevenNCI, Immune Deficiency Cellular Therapy Program, Ctr Canc Res, Bethesda, MD 20892 USA. (author)
Majhail, Navneet S.Cleveland Clin, Taussig Canc Inst, Blood & Marrow Transplant Program, 9500 Euclid Ave,CA 60, Cleveland, OH 44195 USA. (author)
Weisdorf, DanielUniv Minnesota, Dept Med, Div Hematol Oncol & Transplantat, Box 736 UMHC, Minneapolis, MN 55455 USA. (author)
Abdel-Azim, HishamUniv Southern Calif, Div Hematol Oncol & Blood & Marrow Transplantat, Childrens Hosp Los Angeles, Keck Sch Med, Los Angeles, CA 90007 USA. (author)
Agrawal, VaibhavIndiana Univ Sch Med, Div Hematol Oncol, Indianapolis, IN 46202 USA. (author)
Al-Homsi, A. SamerNYU, Langone Med Ctr, New York, NY USA. (author)
Aljurf, MahmoudKing Faisal Specialist Hosp Ctr & Res, Dept Oncol, Riyadh, Saudi Arabia. (author)
Askar, MedhatBaylor Univ, Med Ctr, Dept Pathol & Lab Med, Dallas, TX USA. (author)
Auletta, Jeffery J.Nationwide Childrens Hosp, Blood & Marrow Transplant Program, Columbus, OH USA.;Nationwide Childrens Hosp, Host Def Program, Div Hematol, Columbus, OH USA.;Nationwide Childrens Hosp, Div Oncol, Host Def Program, Columbus, OH USA.;Nationwide Childrens Hosp, Div Bone Marrow Transplant, Host Def Program, Columbus, OH USA.;Nationwide Childrens Hosp, Div Infect Dis, Host Def Program, Columbus, OH USA. (author)
Bashey, AsadNorthside Hosp, Blood & Marrow Transplant Program, Atlanta, GA USA. (author)
Beitinjaneh, AmerUniv Miami, Dept Hematol & Oncol, Miami, FL USA. (author)
Bhatt, Vijaya RajUniv Nebraska Med Ctr, Fred & Pamela Buffett Canc Ctr, Omaha, NE USA. (author)
Byrne, MichaelVanderbilt Univ, Med Ctr, Nashville, TN USA. (author)
Cahn, Jean-YvesCHU Grenoble Alpes, Dept Hematol, Grenoble, France. (author)
Cairo, MitchellNew York Med Coll, Dept Pediat, Div Pediat Hematol Oncol & Stem Cell Transplantat, Valhalla, NY 10595 USA. (author)
Castillo, PaulUF Hlth Shands Childrens Hosp, Gainesville, FL USA. (author)
Cerny, JanUniv Massachusetts, Med Ctr, Dept Med, Div Hematol Oncol, Worcester, MA USA. (author)
Chhabra, SaurabhMed Coll Wisconsin, Dept Med, CIBMTR, Milwaukee, WI 53226 USA. (author)
Choe, HannahOhio State Univ, Wexner Med Ctr, James Comprehens Canc Ctr, Columbus, OH 43210 USA. (author)
Ciurea, StefanUniv Texas MD Anderson Canc Ctr, Houston, TX 77030 USA. (author)
Daly, AndrewTom Baker Canc Clin, Calgary, AB, Canada. (author)
Diaz Perez, Miguel AngelHosp Infantil Univ Nino Jesus, Dept Hematol Oncol, Madrid, Spain. (author)
Farhadfar, NoshaUniv Florida, Coll Med, Div Hematol Oncol, Gainesville, FL USA. (author)
Gadalla, Shahinaz M.NCI, Div Canc Epidemiol & Genet, NIH, Clin Genet Branch, Rockville, MD USA. (author)
Gale, RobertImperial Coll London, Hematol Res Ctr, Dept Med, Div Expt Med, London, England. (author)
Ganguly, SiddharthaUniv Kansas Hlth Syst, Div Hematol Malignancy & Cellular Therapeut, Kansas City, KS USA. (author)
Gergis, UsamaThomas Jefferson Univ, Dept Med Oncol, Philadelphia, PA USA. (author)
Hanna, RabiCleveland Clin Fdn, 9500 Euclid Ave, Cleveland, OH 44195 USA. (author)
Hematti, PeimanUniv Wisconsin, Dept Med, Div Hematol Oncol Bone Marrow Transplantat, Madison, WI USA. (author)
Herzig, RogerUniv Kentucky, Chandler Med Ctr, Louisville, KY USA. (author)
Hildebrandt, Gerhard C.Univ Kentucky, Markey Canc Ctr, Lexington, KY USA. (author)
Lad, Deepesh P.Postgrad Inst Med Educ & Res, Dept Internal Med, Chandigarh, India. (author)
Lee, CatherineUniv Utah, Huntsman Canc Inst, Utah Blood & Marrow Transplant Program, Salt Lake City, UT USA. (author)
Lehmann, LeslieBoston Childrens Hosp, Dana Farber Canc Inst, Boston, MA USA. (author)
Lekakis, LazarosUniv Miami, Dept Hematol & Oncol, Miami, FL USA. (author)
Kamble, Rammurti T.Baylor Coll Med, Ctr Cell & Gene Therapy, Div Hematol & Oncol, Houston, TX 77030 USA. (author)
Kharfan-Dabaja, Mohamed A.Mayo Clin, Div Hematol Oncol, Blood & Marrow Transplantat Program, Jacksonville, FL USA. (author)
Khandelwal, PoojaCincinnati Childrens Hosp Med Ctr, Div Bone Marrow Transplant & Immune Deficiency, Cincinnati, OH 45229 USA.;Univ Cincinnati, Dept Pediat, Cincinnati, OH USA. (author)
Martino, RodrigoHosp Santa Creu & Sant Pau, Div Clin Hematol, Barcelona, Spain. (author)
Murthy, Hemant S.Mayo Clin, Div Hematol Oncol, Blood & Marrow Transplantat Program, Jacksonville, FL USA. (author)
Nishihori, TaigaH Lee Moffitt Canc Ctr & Res Inst, Dept Blood & Marrow Transplant & Cellular Immunot, Tampa, FL USA. (author)
O'Brien, Tracey A.Sydney Childrens Hosp, Kids Canc Ctr, Blood & Marrow Transplant Program, Sydney, NSW, Australia. (author)
Olsson, RichardUppsala universitet,Centrum för klinisk forskning i Sörmland (CKFD),Karolinska Inst, Dept Lab Med, Stockholm, Sweden.(Swepub:uu)riols677 (author)
Patel, Sagar S.Univ Utah, Blood & Marrow Transplant Program, Salt Lake City, UT USA. (author)
Perales, Miguel-AngelMem Sloan Kettering Canc Ctr, Dept Med, Adult Bone Marrow Transplant Serv, 1275 York Ave, New York, NY 10021 USA. (author)
Prestidge, TimStarship Childrens Hosp, Blood & Canc Ctr, Auckland, New Zealand. (author)
Qayed, MunaEmory Univ, Sch Med, Dept Pediat, Atlanta, GA USA. (author)
Romee, RizwanDana Farber Canc Inst, Boston, MA 02115 USA. (author)
Schoemans, HeleneUniv Hosp Leuven, Dept Hematol, Leuven, Belgium.;Katholieke Univ Leuven, Leuven, Belgium. (author)
Seo, SachikoDokkyo Med Univ, Dept Hematol & Oncol, Mibu, Tochigi, Japan. (author)
Sharma, AkshaySt Jude Childrens Res Hosp, Dept Bone Marrow Transplantat & Cellular Therapy, 332 N Lauderdale St, Memphis, TN 38105 USA. (author)
Solh, MelhemNorthside Hosp, Blood & Marrow Transplant Grp Georgia, Atlanta, GA USA. (author)
Strair, RogerRutgers State Univ, Rutgers Canc Inst New Jersey, Brunswick, NJ USA. (author)
Teshima, TakanoriHokkaido Univ Hosp, Sapporo, Hokkaido, Japan. (author)
Urbano-Ispizua, AlvaroUniv Barcelona, Hosp Clin, IDIBAPS, Dept Hematol, Barcelona, Spain.;Inst Res Josep Carreras, Barcelona, Spain. (author)
Van der Poel, MarjoleinMaastricht Univ, Med Ctr, Maastricht, Netherlands. (author)
Vij, RaviWashington Univ, Sch Med, Div Hematol & Oncol, St Louis, MO USA. (author)
Wagner, John L.Thomas Jefferson Univ, Dept Med Oncol, Philadelphia, PA USA. (author)
William, BasemOhio State Univ, Div Hematol, Columbus, OH 43210 USA. (author)
Wirk, BaldeepPenn State Canc Inst, Bone Marrow Transplant Program, Hershey, PA USA. (author)
Yared, Jean A.Univ Maryland, Dept Med, Greenebaum Comprehens Canc Ctr, Blood & Marrow Transplantat Program,Div Hematol O, Baltimore, MD 21201 USA. (author)
Spellman, Steve R.Med Coll Wisconsin, Dept Med, CIBMTR, Milwaukee, WI 53226 USA. (author)
Arora, MuktaUniv Minnesota, Dept Med, Div Hematol Oncol & Transplantat, Box 736 UMHC, Minneapolis, MN 55455 USA. (author)
Hamilton, Betty K.Cleveland Clin, Taussig Canc Inst, Blood & Marrow Transplant Program, 9500 Euclid Ave,CA 60, Cleveland, OH 44195 USA. (author)
Univ Pittsburgh, UPMC, Hillman Canc Ctr, Pittsburgh, PA USA.Univ Minnesota, Dept Med, Div Hematol Oncol & Transplantat, Box 736 UMHC, Minneapolis, MN 55455 USA. (creator_code:org_t)

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In:Biology of blood and marrow transplantation: Elsevier BV26:8, s. 1459-14681083-87911523-6536

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By the author/editor: Im, Annie; Rashidi, Armin; Wang, Tao; Hemmer, Michael; MacMillan, Marga ...; Pidala, Joseph; show more...; Jagasia, Madan; Pavletic, Steven; Majhail, Navneet ...; Weisdorf, Daniel; Abdel-Azim, Hish ...; Agrawal, Vaibhav; Al-Homsi, A. Sam ...; Aljurf, Mahmoud; Askar, Medhat; Auletta, Jeffery ...; Bashey, Asad; Beitinjaneh, Ame ...; Bhatt, Vijaya Ra ...; Byrne, Michael; Cahn, Jean-Yves; Cairo, Mitchell; Castillo, Paul; Cerny, Jan; Chhabra, Saurabh; Choe, Hannah; Ciurea, Stefan; Daly, Andrew; Diaz Perez, Migu ...; Farhadfar, Nosha; Gadalla, Shahina ...; Gale, Robert; Ganguly, Siddhar ...; Gergis, Usama; Hanna, Rabi; Hematti, Peiman; Herzig, Roger; Hildebrandt, Ger ...; Lad, Deepesh P.; Lee, Catherine; Lehmann, Leslie; Lekakis, Lazaros; Kamble, Rammurti ...; Kharfan-Dabaja, ...; Khandelwal, Pooj ...; Martino, Rodrigo; Murthy, Hemant S ...; Nishihori, Taiga; O'Brien, Tracey ...; Olsson, Richard; Patel, Sagar S.; Perales, Miguel- ...; Prestidge, Tim; Qayed, Muna; Romee, Rizwan; Schoemans, Helen ...; Seo, Sachiko; Sharma, Akshay; Solh, Melhem; Strair, Roger; Teshima, Takanor ...; Urbano-Ispizua, ...; Van der Poel, Ma ...; Vij, Ravi; Wagner, John L.; William, Basem; Wirk, Baldeep; Yared, Jean A.; Spellman, Steve ...; Arora, Mukta; Hamilton, Betty ...; show less...

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