SwePub
Sök i LIBRIS databas

  Utökad sökning

WFRF:(Brenner Hermann)
 

Sökning: WFRF:(Brenner Hermann) > Prevalent diabetes ...

  • Amadou, AminaInternational Agency for Research on Cancer (IARC/WHO), Nutrition and Metabolism Branch, Lyon, France; Department of Prevention Cancer Environment, Centre Léon Bérard, Lyon, France (författare)

Prevalent diabetes and risk of total, colorectal, prostate and breast cancers in an ageing population : meta-analysis of individual participant data from cohorts of the CHANCES consortium

  • Artikel/kapitelEngelska2021

Förlag, utgivningsår, omfång ...

  • 2021-03-26
  • Nature Publishing Group,2021
  • printrdacarrier

Nummerbeteckningar

  • LIBRIS-ID:oai:DiVA.org:umu-182156
  • https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-182156URI
  • https://doi.org/10.1038/s41416-021-01347-4DOI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • Background: We investigated whether associations between prevalent diabetes and cancer risk are pertinent to older adults and whether associations differ across subgroups of age, body weight status or levels of physical activity.Methods: We harmonised data from seven prospective cohort studies of older individuals in Europe and the United States participating in the CHANCES consortium. Cox proportional hazard regression was used to estimate the associations of prevalent diabetes with cancer risk (all cancers combined, and for colorectum, prostate and breast). We calculated summary risk estimates across cohorts using pooled analysis and random-effects meta-analysis.Results: A total of 667,916 individuals were included with an overall median (P25–P75) age at recruitment of 62.3 (57–67) years. During a median follow-up time of 10.5 years, 114,404 total cancer cases were ascertained. Diabetes was not associated with the risk of all cancers combined (hazard ratio (HR) = 0.94; 95% confidence interval (CI): 0.86–1.04; I2 = 63.3%). Diabetes was positively associated with colorectal cancer risk in men (HR = 1.17; 95% CI: 1.08–1.26; I2 = 0%) and a similar HR in women (1.13; 95% CI: 0.82–1.56; I2 = 46%), but with a confidence interval including the null. Diabetes was inversely associated with prostate cancer risk (HR = 0.81; 95% CI: 0.77–0.85; I2 = 0%), but not with postmenopausal breast cancer (HR = 0.96; 95% CI: 0.89–1.03; I2 = 0%). In exploratory subgroup analyses, diabetes was inversely associated with prostate cancer risk only in men with overweight or obesity.Conclusions: Prevalent diabetes was positively associated with colorectal cancer risk and inversely associated with prostate cancer risk in older Europeans and Americans.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Freisling, HeinzInternational Agency for Research on Cancer (IARC/WHO), Nutrition and Metabolism Branch, Lyon, France (författare)
  • Jenab, MazdaInternational Agency for Research on Cancer (IARC/WHO), Nutrition and Metabolism Branch, Lyon, France (författare)
  • Tsilidis, Konstantinos K.Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina, Greece; Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, United Kingdom (författare)
  • Trichopoulou, AntoniaHellenic Health Foundation, Athens, Greece (författare)
  • Boffetta, PaoloStony Brook Cancer Center, Stony Brook University, NY, Stony Brook, United States; Department of Medical and Surgical Sciences, University of Bologna, Bologna, Italy (författare)
  • van Guelpen, BethanyUmeå universitet,Wallenberg centrum för molekylär medicin vid Umeå universitet (WCMM),Onkologi(Swepub:umu)beyvan99 (författare)
  • Mokoroa, OlatzPublic Health Division of Gipuzkoa, BioDonostia Research Institute, San Sebastian, Spain (författare)
  • Wilsgaard, TomDepartment of Community Medicine, UiT The Arctic University of Norway, Tromsø, Norway (författare)
  • Kee, FrankInstitute for Health Sciences Risk and Inequality, Centre for Public Health, Belfast, United Kingdom (författare)
  • Schöttker, BenDivision of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany (författare)
  • Ordóñez-Mena, José M.Nuffield Department of Primary Care Health Sciences, Radcliffe Observatory Quarter, Woodstock Road, Oxford, United Kingdom; NIHR Oxford Biomedical Research Centre, Oxford University Hospitals NHS Foundation Trust, Oxford, United Kingdom (författare)
  • Männistö, SatuDepartment of Public Health and Welfare, Finnish Institute for Health and Welfare (THL), Helsinki, Finland (författare)
  • Söderberg, StefanUmeå universitet,Avdelningen för medicin(Swepub:umu)stso0001 (författare)
  • Vermeulen, Roel C. H.Environmental Epidemiology, Institute for Risk Assessment Sciences (IRAS), Utrecht University, Utrecht, Netherlands (författare)
  • Quirós, J. RamónPublic Health Directorate, Asturias, Spain (författare)
  • Liao, Linda M.Division of Cancer Epidemiology and Genetics, National Cancer Institute, MD, Bethesda, United States (författare)
  • Sinha, RashmiDivision of Cancer Epidemiology and Genetics, National Cancer Institute, MD, Bethesda, United States (författare)
  • Kuulasmaa, KariDepartment of Public Health and Welfare, Finnish Institute for Health and Welfare (THL), Helsinki, Finland (författare)
  • Brenner, HermannDivision of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany; Division of Preventive Oncology, German Cancer Research Center (DKFZ) and National Center for Tumor Diseases (NCT), Heidelberg, Germany; German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany (författare)
  • Romieu, IsabelleInternational Agency for Research on Cancer (IARC/WHO), Nutrition and Metabolism Branch, Lyon, France (författare)
  • International Agency for Research on Cancer (IARC/WHO), Nutrition and Metabolism Branch, Lyon, France; Department of Prevention Cancer Environment, Centre Léon Bérard, Lyon, FranceInternational Agency for Research on Cancer (IARC/WHO), Nutrition and Metabolism Branch, Lyon, France (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:British Journal of Cancer: Nature Publishing Group124:11, s. 1882-18900007-09201532-1827

Internetlänk

Hitta via bibliotek

Till lärosätets databas

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Stäng

Kopiera och spara länken för att återkomma till aktuell vy