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  • Robbins, Hilary A.Genomic Epidemiology Branch, International Agency for Research on Cancer, Lyon, France (författare)

Design and methodological considerations for biomarker discovery and validation in the Integrative Analysis of Lung Cancer Etiology and Risk (INTEGRAL) Program

  • Artikel/kapitelEngelska2023

Förlag, utgivningsår, omfång ...

  • Elsevier,2023
  • electronicrdacarrier

Nummerbeteckningar

  • LIBRIS-ID:oai:DiVA.org:umu-201376
  • https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-201376URI
  • https://doi.org/10.1016/j.annepidem.2022.10.014DOI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

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Klassifikation

  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • The Integrative Analysis of Lung Cancer Etiology and Risk (INTEGRAL) program is an NCI-funded initiative with an objective to develop tools to optimize low-dose CT (LDCT) lung cancer screening. Here, we describe the rationale and design for the Risk Biomarker and Nodule Malignancy projects within INTEGRAL. The overarching goal of these projects is to systematically investigate circulating protein markers to include on a panel for use (i) pre-LDCT, to identify people likely to benefit from screening, and (ii) post-LDCT, to differentiate benign versus malignant nodules. To identify informative proteins, the Risk Biomarker project measured 1161 proteins in a nested-case control study within 2 prospective cohorts (n = 252 lung cancer cases and 252 controls) and replicated associations for a subset of proteins in 4 cohorts (n = 479 cases and 479 controls). Eligible participants had a current or former history of smoking and cases were diagnosed up to 3 years following blood draw. The Nodule Malignancy project measured 1078 proteins among participants with a heavy smoking history within four LDCT screening studies (n = 425 cases diagnosed up to 5 years following blood draw, 430 benign-nodule controls, and 398 nodule-free controls). The INTEGRAL panel will enable absolute quantification of 21 proteins. We will evaluate its performance in the Risk Biomarker project using a case-cohort study including 14 cohorts (n = 1696 cases and 2926 subcohort representatives), and in the Nodule Malignancy project within five LDCT screening studies (n = 675 cases, 680 benign-nodule controls, and 648 nodule-free controls). Future progress to advance lung cancer early detection biomarkers will require carefully designed validation, translational, and comparative studies.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Alcala, KarineGenomic Epidemiology Branch, International Agency for Research on Cancer, Lyon, France (författare)
  • Moez, Elham KhodayariProsserman Centre for Population Health Research, Lunenfeld-Tanenbaum Research Institute, Sinai Health, Toronto, Canada (författare)
  • Guida, FlorenceEnvironment and Lifestyle Epidemiology Branch, International Agency for Research on Cancer, Lyon, France (författare)
  • Thomas, SeraProsserman Centre for Population Health Research, Lunenfeld-Tanenbaum Research Institute, Sinai Health, Toronto, Canada (författare)
  • Zahed, HanaGenomic Epidemiology Branch, International Agency for Research on Cancer, Lyon, France (författare)
  • Warkentin, Matthew T.Prosserman Centre for Population Health Research, Lunenfeld-Tanenbaum Research Institute, Sinai Health, Toronto, Canada; Dalla Lana School of Public Health, University of Toronto, Toronto, Canada (författare)
  • Smith-Byrne, KarlCancer Epidemiology Unit, University of Oxford, Oxford, United Kingdom (författare)
  • Brhane, YonathanProsserman Centre for Population Health Research, Lunenfeld-Tanenbaum Research Institute, Sinai Health, Toronto, Canada (författare)
  • Muller, DavidDivision of Genetic Medicine, Imperial College London School of Public Health, London, United Kingdom (författare)
  • Feng, XiaoshuangGenomic Epidemiology Branch, International Agency for Research on Cancer, Lyon, France (författare)
  • Albanes, DemetriusDivision of Cancer Epidemiology and Genetics, National Cancer Institute, MD, Rockville (författare)
  • Aldrich, Melinda C.Department of Medicine, Vanderbilt University Medical Center, TN, Nashville, United States (författare)
  • Arslan, Alan A.Departments of Obstetrics and Gynecology and Population Health, New York University Grossman School of Medicine, NY, New York, United States (författare)
  • Bassett, JulieCancer Epidemiology Division, Cancer Council Victoria, Melbourne, Australia (författare)
  • Berg, Christine D.Retired, MD, Bethesda (författare)
  • Cai, QiuyinDivision of Epidemiology, Department of Medicine, Vanderbilt University Medical Center, TN, Nashville, United States (författare)
  • Chen, ChuProgram in Epidemiology and the Women's Health Initiative Clinical Coordinating Center, Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, WA, Seattle, United States (författare)
  • Davies, Michael P.A.Molecular & Clinical Cancer Medicine, University of Liverpool, Liverpool, United Kingdom (författare)
  • Diergaarde, BrendaDepartment of Human Genetics, Graduate School of Public Health, University of Pittsburgh, PA, Pittsburgh, United States; UPMC Hillman Cancer Centre, PA, Pittsburgh, United States (författare)
  • Field, John K.Molecular & Clinical Cancer Medicine, University of Liverpool, Liverpool, United Kingdom (författare)
  • Freedman, Neal D.Division of Cancer Epidemiology and Genetics, National Cancer Institute, MD, Rockville (författare)
  • Huang, Wen-YiDivision of Cancer Epidemiology and Genetics, National Cancer Institute, MD, Rockville (författare)
  • Johansson, MikaelUmeå universitet,Onkologi(Swepub:umu)mijo0025 (författare)
  • Jones, MichaelDivision of Genetics and Epidemiology, Institute of Cancer Research, London, United Kingdom (författare)
  • Koh, Woon-PuayHealthy Longevity Translational Research Program, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore; Singapore Institute for Clinical Sciences, Agency for Science Technology and Research (A*STAR), Singapore, Singapore (författare)
  • Lam, StephenIntegrative Oncology, British Columbia Cancer Agency, Vancouver, Canada (författare)
  • Lan, QingDivision of Cancer Epidemiology and Genetics, National Cancer Institute, MD, Rockville (författare)
  • Langhammer, ArnulfHUNT Research Center, Department of Public Health and Nursing, NTNU Norwegian University of Science and Technology, Levanger, Norway; Levanger Hospital, Nord-Trøndelag Hospital Trust, Levanger, Norway (författare)
  • Liao, Linda M.Division of Cancer Epidemiology and Genetics, National Cancer Institute, MD, Rockville (författare)
  • Liu, GeoffreyComputational Biology and Medicine Program, Princess Margaret Cancer Center, Toronto, Canada (författare)
  • Malekzadeh, RezaDigestive Disease Research Institute, Tehran University of Medical Sciences, Tehran, Iran (författare)
  • Milne, Roger L.Cancer Epidemiology Division, Cancer Council Victoria, Melbourne, Australia; Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne, Parkville, Australia; School of Clinical Sciences at Monash Health, Monash University, Melbourne, Australia (författare)
  • Montuenga, Luis M.Center of Applied Medical Research (CIMA) and Schools of Sciences and Medicine, University of Navarra, Pamplona, Spain; IDISNA, Pamplona, Spain; CIBERONC, Madrid, Spain (författare)
  • Rohan, ThomasDepartment of Epidemiology & Population Health, Albert Einstein College of Medicine, NY, Bronx, United States (författare)
  • Sesso, Howard D.Brigham and Women's Hospital, Harvard Medical School, MA, Boston (författare)
  • Severi, GianlucaInserm, Université Paris-Saclay, Villejuif, France (författare)
  • Sheikh, MahdiGenomic Epidemiology Branch, International Agency for Research on Cancer, Lyon, France (författare)
  • Sinha, RashmiDivision of Cancer Epidemiology and Genetics, National Cancer Institute, MD, Rockville (författare)
  • Shu, Xiao-OuDivision of Epidemiology, Department of Medicine, Vanderbilt University Medical Center, TN, Nashville, United States (författare)
  • Stevens, Victoria L.Rollins School of Public Health, Emory University, GA, Atlanta (författare)
  • Tammemägi, Martin C.Department of Health Sciences, Brock University, ON, St. Cathaarines, Canada; Prevention and Cancer Control, Ontario Health, ON, Toronto, Canada (författare)
  • Tinker, Lesley F.Women's Health Initiative Clinical Coordinating Center, Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, WA, Seattle, United States (författare)
  • Visvanathan, KalaDepartment of Epidemiology, Johns Hopkins Bloomberg School of Public Health, MD, Baltimore (författare)
  • Wang, YingAmerican Cancer Society, GA, Atlanta (författare)
  • Wang, RenweiUPMC Hillman Cancer Center, University of Pittsburgh, PA, Pittsburgh, United States (författare)
  • Weinstein, Stephanie J.Division of Cancer Epidemiology and Genetics, National Cancer Institute, MD, Rockville (författare)
  • White, EmilyCancer Prevention Research Program, Fred Hutchinson Cancer Research Center, WA, Seattle, United States (författare)
  • Wilson, DavidDivision of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, University of Pittsburgh, PA, Pittsburgh, United States (författare)
  • Yuan, Jian-MinUPMC Hillman Cancer Centre, PA, Pittsburgh, United States; Department of Epidemiology, Graduate Schoolf of Public Health, University of Pittsburgh, PA, Pittsburgh, United States (författare)
  • Zhang, XuehongBrigham and Women's Hospital, Harvard Medical School, MA, Boston (författare)
  • Zheng, WeiDivision of Epidemiology, Department of Medicine, Vanderbilt University Medical Center, TN, Nashville, United States (författare)
  • Amos, Christopher I.Institute for Clinical and Translational Research, Baylor College of Medicine, TX, Houston, United States (författare)
  • Brennan, PaulGenomic Epidemiology Branch, International Agency for Research on Cancer, Lyon, France (författare)
  • Johansson, MattiasGenomic Epidemiology Branch, International Agency for Research on Cancer, Lyon, France (författare)
  • Hung, Rayjean J.Prosserman Centre for Population Health Research, Lunenfeld-Tanenbaum Research Institute, Sinai Health, Toronto, Canada; Dalla Lana School of Public Health, University of Toronto, Toronto, Canada (författare)
  • Genomic Epidemiology Branch, International Agency for Research on Cancer, Lyon, FranceProsserman Centre for Population Health Research, Lunenfeld-Tanenbaum Research Institute, Sinai Health, Toronto, Canada (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:Annals of Epidemiology: Elsevier77, s. 1-121047-27971873-2585

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