Dietary exposure to polychlorinated biphenyls and risk of heart failure - A population-based prospective cohort study

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Akesson, AgnetaKarolinska Institutet (author)

Dietary exposure to polychlorinated biphenyls and risk of heart failure - A population-based prospective cohort study

Article/chapterEnglish2019

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PERGAMON-ELSEVIER SCIENCE LTD,2019
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LIBRIS-ID:oai:DiVA.org:uu-419402
https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-419402URI
https://doi.org/10.1016/j.envint.2019.01.069DOI
http://kipublications.ki.se/Default.aspx?queryparsed=id:140628251URI
https://res.slu.se/id/publ/99508URI

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Language:English
Summary in:English

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Background: Beneficial effects of fish consumption on heart failure (HF) may be modified by contaminants in fish. Polychlorinated biphenyls (PCBs) are of particular concern as they have been associated with well-established risk factors of HF, but current data are limited. Objectives: We aimed to assess the association between dietary PCB exposure and risk of HF, accounting for dietary intake of long-chain omega-3 fish fatty acids. Design: We used the prospective population-based research structure SIMPLER (previously the Swedish Mammography Cohort and Cohort of Swedish Men) comprising 32,952 women and 36,546 men, free from cancer, cardiovascular disease and diabetes at baseline in 1997. Validated estimates of dietary PCBs and long-chain omega-3 fish fatty acids [eicosapentaenoic acid (EPA), and docosahexaenoic acid (DHA)] were obtained via a food frequency questionnaire at baseline. Incident cases of HF were ascertained through register linkage. Results: During an average of 12 years of follow-up, we ascertained 2736 and 3128 incident cases of HF in women and men, respectively. In multivariable-adjusted models, mutually adjusted for PCBs and EPA-DHA, the relative risk (RR) for dietary PCB exposure was 1.48 (95% CI 1.12-1.96) in women and 1.42 (95% CI 1.08-1.86) in men, comparing extreme quintiles. Corresponding RRs for EPA-DHA intake were 0.71 (95% CI 0.54-0.93) and 0.82 (95% CI 0.63-1.07), respectively. Conclusions: Dietary exposure to PCBs was associated with an increased risk of HF in both women and men. EPA-DHA intake was associated with a lower risk of HF in women, with a similar tendency in men.

Subject headings and genre

MEDICIN OCH HÄLSOVETENSKAP Hälsovetenskap Näringslära hsv//swe
MEDICAL AND HEALTH SCIENCES Health Sciences Nutrition and Dietetics hsv//eng
MEDICIN OCH HÄLSOVETENSKAP Hälsovetenskap Arbetsmedicin och miljömedicin hsv//swe
MEDICAL AND HEALTH SCIENCES Health Sciences Occupational Health and Environmental Health hsv//eng
Heart failure
Fish
Polychlorinated biphenyls
Long-chain omega-3 fish fatty acids

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Donat-Vargas, CarolinaKarolinska Institutet (author)
Berglund, MarikaKarolinska Institutet (author)
Glynn, AndersSwedish University of Agricultural Sciences,Sveriges lantbruksuniversitet,Inst för biomedicin och veterinär folkhälsovetenskap,Department of Biomedical Science and Veterinary Public Health (author)
Wolk, AlicjaKarolinska Inst, Inst Environm Med, Box 210, SE-17177 Stockholm, Sweden. (author)
Kippler, MariaKarolinska Institutet (author)
Karolinska InstitutetInst för biomedicin och veterinär folkhälsovetenskap (creator_code:org_t)
Sveriges lantbruksuniversitet

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In:Environment International: PERGAMON-ELSEVIER SCIENCE LTD126, s. 1-60160-41201873-6750

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By the author/editor: Akesson, Agneta; Donat-Vargas, Ca ...; Berglund, Marika; Glynn, Anders; Wolk, Alicja; Kippler, Maria

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MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Health Sciences; and Nutrition and Di ...

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