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  • Alsharari, ZayedUppsala universitet,Klinisk nutrition och metabolism (author)

Association between carbohydrate intake and fatty acids in the de novo lipogenic pathway in serum phospholipids and adipose tissue in a population of Swedish men

  • Article/chapterEnglish2020

Publisher, publication year, extent ...

  • 2019-07-26
  • Springer Science and Business Media LLC,2020
  • electronicrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:uu-419550
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-419550URI
  • https://doi.org/10.1007/s00394-019-02058-6DOI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:144137603URI

Supplementary language notes

  • Language:English
  • Summary in:English

Part of subdatabase

Classification

  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Purpose Fatty acid composition in blood and adipose tissue (AT) is a useful biomarker of dietary fat quality. However, circulating saturated fatty acids (SFA) and monounsaturated fatty acids (MUFA) have been proposed to also reflect carbohydrate-induced de novo lipogenesis (DNL) and stearoyl-CoA desaturase (SCD) activity. We aimed to test the hypothesis that high carbohydrate intake is related to SFA and MUFA in serum or AT in a Swedish population. Methods Fatty acid composition was measured in serum phospholipids (PL) and AT by gas chromatography in 63-year-old men (n = 299). Carbohydrate and alcohol intake was assessed (validated 7-day food records) in relation to total SFA, 16:0 (palmitate), 16:1 (palmitoleate), and estimated SCD activity (16:1n-7/16:0-ratio) in serum PL and in AT, respectively. Results Total carbohydrate intake was inversely associated with 16:0 in PL (P = 0.005), independently of BMI. Disaccharides were non-linearly (restricted cubic splines) and weakly associated with 16:1 and SCD activity in PL (nonlinear trend,P <= 0.02) but not AT. Carbohydrate intake and SCD expression were not associated (P >= 0.08,n = 81). Alcohol intake was, however, linearly associated with 16:0 in PL (P < 0.001), and with 16:1 (P < 0.001) and SCD activity (P <= 0.005) in both PL and AT. Conclusions Higher carbohydrate intake from sugar-rich foods or beverages was not clearly reflected by higher SFA or SCD activity in serum PL or AT. Alcohol was, however, associated with higher SFA and MUFA.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Leander, KarinKarolinska Institutet (author)
  • Sjögren, PerUppsala universitet,Klinisk nutrition och metabolism(Swepub:uu)persj732 (author)
  • Carlsson, AxelKarolinska Institutet (author)
  • Cederholm, TommyKarolinska Institutet,Uppsala universitet,Klinisk nutrition och metabolism(Swepub:uu)tomce419 (author)
  • de Faire, UlfKarolinska Institutet (author)
  • Hellenius, Mai-LisKarolinska Institutet (author)
  • Marklund, MattiUppsala universitet,Klinisk nutrition och metabolism(Swepub:uu)matma701 (author)
  • Risérus, Ulf,1967-Uppsala universitet,Klinisk nutrition och metabolism(Swepub:uu)ulfriser (author)
  • Uppsala universitetKlinisk nutrition och metabolism (creator_code:org_t)

Related titles

  • In:European Journal of Nutrition: Springer Science and Business Media LLC59:5, s. 2089-20971436-62071436-6215

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