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Decreased spermatogonial numbers in boys with severe haematological diseases

Lahtinen, Atte K. (author)
Applied Tumor Genomics Research Program, Faculty of Medicine, University of Helsinki, Helsinki, Finland; Department of Medical and Clinical Genetics/Medicum, Faculty of Medicine, University of Helsinki, Helsinki, Finland
Funke, Miriam (author)
Centre of Reproductive Medicine and Andrology, Institute of Reproductive and Regenerative Biology, University Münster, Munster, Germany
Krallmann, Claudia (author)
Department of Clinical and Surgical Andrology, Centre of Reproductive Medicine and Andrology, University Hospital Münster, Munster, Germany
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Wyrwoll, Margot J. (author)
Department of Clinical and Surgical Andrology, Centre of Reproductive Medicine and Andrology, University Hospital Münster, Munster, Germany
Jarisch, Andrea (author)
Division of Stem Cell Transplantation and Immunology, Department of Children and Adolescent Medicine, University Hospital Frankfurt, Johann Wolfgang Goethe University, Frankfurt am Main, Germany
Yang, Yifan (author)
NORDFERTIL Research Lab Stockholm, Department of Women's and Children's Health, Karolinska Institutet and Karolinska University Hospital, Stockholm, Sweden
Bjarnason, Ragnar (author)
Children's Medical Center, Landspítali University Hospital, Reykjavik, Iceland; Department of Paediatrics, Faculty of Medicine, University of Iceland, Reykjavik, Iceland
Romerius, Patrik (author)
Department of Paediatric Oncology and Haematology, Clinical Sciences, Lund University, Barn-Och Ungdomssjukhuset Lund, Skånes Universitetssjukhus, Lund, Sweden
Sundin, Mikael (author)
Division of Paediatrics, Department of Clinical Science, Intervention and Technology, Karolinska Institutet, Stockholm, Sweden; Section of Paediatric Haematology, Immunology and HCT, Astrid Lindgren Children's Hospital, Karolinska University Hospital, Stockholm, Sweden
Norén-Nyström, Ulrika (author)
Umeå universitet,Pediatrik
Langenskiöld, Cecilia (author)
Department of Paediatric Oncology, The Queen Silvia Children's Hospital, Gothenburg, Sweden
Cremers, Jann-Frederik (author)
Department of Clinical and Surgical Andrology, Centre of Reproductive Medicine and Andrology, University Hospital Münster, Munster, Germany
Kliesch, Sabine (author)
Department of Clinical and Surgical Andrology, Centre of Reproductive Medicine and Andrology, University Hospital Münster, Munster, Germany
Stukenborg, Jan-Bernd (author)
Karolinska Institutet
Neuhaus, Nina (author)
Centre of Reproductive Medicine and Andrology, Institute of Reproductive and Regenerative Biology, University Münster, Munster, Germany
Jahnukainen, Kirsi (author)
NORDFERTIL Research Lab Stockholm, Department of Women's and Children's Health, Karolinska Institutet and Karolinska University Hospital, Stockholm, Sweden; New Children's Hospital, Pediatric Research Center, University of Helsinki and Helsinki University Hospital, Helsinki, Finland
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 (creator_code:org_t)
John Wiley & Sons, 2024
2024
English.
In: British Journal of Haematology. - : John Wiley & Sons. - 0007-1048 .- 1365-2141. ; 205:1, s. 229-235
  • Journal article (peer-reviewed)
Abstract Subject headings
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  • This study examines spermatogonial numbers in testicular samples from 43 prepubertal patients undergoing haematopoietic stem cell transplantation (HSCT). High-dose chemotherapy and/or radiation during HSCT can impact spermatogenesis requiring fertility preservation. Results show that 49% of patients have decreased and 19% severely depleted spermatogonial pool prior to HSCT. Patients with Fanconi anaemia exhibit significantly reduced spermatogonial numbers. Patients with immunodeficiency or aplastic anaemia generally present within the normal range, while results in patients with myelodysplastic syndrome or myeloproliferative neoplasm vary. The study emphasizes the importance of assessing spermatogonial numbers in patients with severe haematological diseases for informed fertility preservation decisions.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Hematologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Hematology (hsv//eng)

Keyword

bone marrow failure
fertility
immunodeficiency
MDS
myeloproliferative disease
stem cell transplantation

Publication and Content Type

ref (subject category)
art (subject category)

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