The Influence of Comorbidity on Health-Related Quality of Life After Esophageal Cancer Surgery

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Backemar, LovisaKarolinska Univ Hosp, Karolinska Inst, Dept Mol Med & Surg, Surg Care Sci, Stockholm, Sweden. (author)

The Influence of Comorbidity on Health-Related Quality of Life After Esophageal Cancer Surgery

Article/chapterEnglish2020

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2020-03-11
Springer Science and Business Media LLC,2020
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LIBRIS-ID:oai:DiVA.org:uu-419777
https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-419777URI
https://doi.org/10.1245/s10434-020-08303-1DOI
http://kipublications.ki.se/Default.aspx?queryparsed=id:144077698URI

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Language:English
Summary in:English

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Subject category:art swepub-publicationtype

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BackgroundEsophageal cancer surgery reduces patients’ health-related quality of life (HRQoL). This study examined whether comorbidities influence HRQoL in these patients.MethodsThis prospective cohort study included esophageal cancer patients having undergone curatively intended esophagectomy at St Thomas’ Hospital London in 2011–2015. Clinical data were collected from patient reports and medical records. Well-validated cancer-specific and esophageal cancer-specific questionnaires (EORTC QLQ-C30 and QLQ-OG25) were used to assess HRQoL before and 6 months after esophagectomy. Number of comorbidities, American Society of Anesthesiologists physical status classification (ASA), and specific comorbidities were analyzed in relation to HRQoL aspects using multivariable linear regression models. Mean score differences with 95% confidence intervals were adjusted for potential confounders.ResultsAmong 136 patients, those with three or more comorbidities at the time of surgery had poorer global quality of life and physical function and more fatigue compared with those with no comorbidity. Patients with ASA III–IV reported more problems with the above HRQoL aspects and worse social function and pain compared with those with ASA I–II. Cardiac comorbidity was associated with worse global quality of life and dyspnea, while pulmonary comorbidities were related to coughing. Patients assessed both before and 6 months after surgery (n = 80) deteriorated in most HRQoL aspects regardless of comorbidity status, but patients with several comorbidities had worse physical function and fatigue and more trouble with coughing compared with those with fewer comorbidities.ConclusionComorbidity appears to negatively influence HRQoL before esophagectomy, but appears not to severely impact 6-month recovery of HRQoL.

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Johar, AsifKarolinska Univ Hosp, Karolinska Inst, Dept Mol Med & Surg, Surg Care Sci, Stockholm, Sweden. (author)
Wikman, AnnaUppsala universitet,Reproduktiv hälsa(Swepub:uu)annwi617 (author)
Zylstra, JanineKarolinska Univ Hosp, Karolinska Inst, Dept Mol Med & Surg, Upper Gastrointestinal Surg, Stockholm, Sweden.;Kings Coll London, Sch Canc & Pharmaceut Sci, London, England.;Guys & St Thomas NHS Trust, Upper Gastrointestinal Surg, London, England. (author)
Gossage, JamesKarolinska Univ Hosp, Karolinska Inst, Dept Mol Med & Surg, Upper Gastrointestinal Surg, Stockholm, Sweden.;Kings Coll London, Sch Canc & Pharmaceut Sci, London, England.;Guys & St Thomas NHS Trust, Upper Gastrointestinal Surg, London, England. (author)
Davies, AndrewKarolinska Univ Hosp, Karolinska Inst, Dept Mol Med & Surg, Upper Gastrointestinal Surg, Stockholm, Sweden.;Kings Coll London, Sch Canc & Pharmaceut Sci, London, England.;Guys & St Thomas NHS Trust, Upper Gastrointestinal Surg, London, England. (author)
Lagergren, JesperKarolinska Institutet (author)
Lagergren, PernillaKarolinska Institutet (author)
Karolinska Univ Hosp, Karolinska Inst, Dept Mol Med & Surg, Surg Care Sci, Stockholm, Sweden.Reproduktiv hälsa (creator_code:org_t)

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By the author/editor: Backemar, Lovisa; Johar, Asif; Wikman, Anna; Zylstra, Janine; Gossage, James; Davies, Andrew; show more...; Lagergren, Jespe ...; Lagergren, Perni ...; show less...

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MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Surgery

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Cancer and Oncol ...

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Gastroenterology ...

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