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A cross-omics integ...
A cross-omics integrative study of metabolic signatures of chronic obstructive pulmonary disease
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- Prokic, Ivana (författare)
- Erasmus MC, Dept Epidemiol, Rotterdam, Netherlands.
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- Lahousse, Lies (författare)
- Erasmus MC, Dept Epidemiol, Rotterdam, Netherlands.;Univ Ghent, Dept Bioanal, Pharmaceut Care Unit, Ghent, Belgium.
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- de Vries, Maaike (författare)
- Univ Groningen, Univ Med Ctr Groningen, Dept Epidemiol, Groningen, Netherlands.;Univ Groningen, Univ Med Ctr Groningen, Groningen Res Inst Asthma & COPD GRIAC, Groningen, Netherlands.
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- Liu, Jun (författare)
- Erasmus MC, Dept Epidemiol, Rotterdam, Netherlands.;Univ Oxford, Nuffield Dept Populat Hlth, Oxford, England.
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- Kalaoja, Marita (författare)
- Univ Oulu, Ctr Life Course Hlth Res, Bioctr Oulu, Computat Med Dept, Oulu, Finland.
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- Vonk, Judith M. (författare)
- Univ Groningen, Univ Med Ctr Groningen, Dept Epidemiol, Groningen, Netherlands.;Univ Groningen, Univ Med Ctr Groningen, Groningen Res Inst Asthma & COPD GRIAC, Groningen, Netherlands.
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- van der Plaat, Diana A. (författare)
- Univ Groningen, Univ Med Ctr Groningen, Dept Epidemiol, Groningen, Netherlands.;Univ Groningen, Univ Med Ctr Groningen, Groningen Res Inst Asthma & COPD GRIAC, Groningen, Netherlands.;Imperial Coll London, Natl Heart & Lung Inst, London, England.
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- van Diemen, Cleo C. (författare)
- Univ Groningen, Univ Med Ctr Groningen, Dept Genet, Groningen, Netherlands.
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- van der Spek, Ashley (författare)
- Erasmus MC, Dept Epidemiol, Rotterdam, Netherlands.
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- Zhernakova, Alexandra (författare)
- Univ Groningen, Univ Med Ctr Groningen, Dept Genet, Groningen, Netherlands.
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- Fu, Jingyuan (författare)
- Univ Groningen, Univ Med Ctr Groningen, Dept Genet, Groningen, Netherlands.;Univ Groningen, Univ Med Ctr Groningen, Dept Pediat, Groningen, Netherlands.
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- Ghanbari, Mohsen (författare)
- Erasmus MC, Dept Epidemiol, Rotterdam, Netherlands.;Mashhad Univ Med Sci, Sch Med, Dept Genet, Mashhad, Razavi Khorasan, Iran.
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- Ala-Korpela, Mika (författare)
- Univ Oulu, Ctr Life Course Hlth Res, Bioctr Oulu, Computat Med Dept, Oulu, Finland.;Univ Eastern Finland, Sch Pharm, NMR Metabol Lab, Kuopio, Finland.
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- Kettunen, Johannes (författare)
- Univ Oulu, Ctr Life Course Hlth Res, Bioctr Oulu, Computat Med Dept, Oulu, Finland.;Finnish Inst Hlth & Welf, Helsinki, Finland.
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- Havulinna, Aki S. (författare)
- Finnish Inst Hlth & Welf, Helsinki, Finland.;Univ Helsinki, Fac Med, Mol Metab Res Program, Helsinki, Finland.
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- Perola, Markus (författare)
- Finnish Inst Hlth & Welf, Helsinki, Finland.;Univ Helsinki, Fac Med, Mol Metab Res Program, Helsinki, Finland.
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- Salomaa, Veikko (författare)
- Finnish Inst Hlth & Welf, Helsinki, Finland.
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- Lind, Lars (författare)
- Uppsala universitet,Klinisk epidemiologi
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- Ärnlöv, Johan, 1970- (författare)
- Högskolan Dalarna,Karolinska Institutet,Medicinsk vetenskap
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- Stricker, Bruno H. C. (författare)
- Erasmus MC, Dept Epidemiol, Rotterdam, Netherlands.
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- Brusselle, Guy G. (författare)
- Erasmus MC, Dept Epidemiol, Rotterdam, Netherlands.;Ghent Univ Hosp, Dept Resp Med, Ghent, Belgium.;Erasmus MC, Dept Resp Med, Rotterdam, Netherlands.
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- Boezen, H. Marike (författare)
- Univ Groningen, Univ Med Ctr Groningen, Dept Epidemiol, Groningen, Netherlands.;Univ Groningen, Univ Med Ctr Groningen, Groningen Res Inst Asthma & COPD GRIAC, Groningen, Netherlands.
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- van Duijn, Cornelia M. (författare)
- Erasmus MC, Dept Epidemiol, Rotterdam, Netherlands.;Univ Oxford, Nuffield Dept Populat Hlth, Oxford, England.
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- Amin, Najaf (författare)
- Erasmus MC, Dept Epidemiol, Rotterdam, Netherlands.;Univ Oxford, Nuffield Dept Populat Hlth, Oxford, England.
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Erasmus MC, Dept Epidemiol, Rotterdam, Netherlands Erasmus MC, Dept Epidemiol, Rotterdam, Netherlands.;Univ Ghent, Dept Bioanal, Pharmaceut Care Unit, Ghent, Belgium. (creator_code:org_t)
- 2020-07-16
- 2020
- Engelska.
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Ingår i: BMC Pulmonary Medicine. - : Springer Science and Business Media LLC. - 1471-2466. ; 20:1
- Relaterad länk:
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https://doi.org/10.1...
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https://uu.diva-port... (primary) (Raw object)
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https://bmcpulmmed.b...
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https://du.diva-port... (primary) (Raw object)
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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https://urn.kb.se/re...
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Abstract
Ämnesord
Stäng
- BackgroundChronic obstructive pulmonary disease (COPD) is a common lung disorder characterized by persistent and progressive airflow limitation as well as systemic changes. Metabolic changes in blood may help detect COPD in an earlier stage and predict prognosis.MethodsWe conducted a comprehensive study of circulating metabolites, measured by proton Nuclear Magnetic Resonance Spectroscopy, in relation with COPD and lung function. The discovery sample consisted of 5557 individuals from two large population-based studies in the Netherlands, the Rotterdam Study and the Erasmus Rucphen Family study. Significant findings were replicated in 12,205 individuals from the Lifelines-DEEP study, FINRISK and the Prospective Investigation of the Vasculature in Uppsala Seniors (PIVUS) studies. For replicated metabolites further investigation of causality was performed, utilizing genetics in the Mendelian randomization approach.ResultsThere were 602 cases of COPD and 4955 controls used in the discovery meta-analysis. Our logistic regression results showed that higher levels of plasma Glycoprotein acetyls (GlycA) are significantly associated with COPD (OR = 1.16, P = 5.6 × 10− 4 in the discovery and OR = 1.30, P = 1.8 × 10− 6 in the replication sample). A bi-directional two-sample Mendelian randomization analysis suggested that circulating blood GlycA is not causally related to COPD, but that COPD causally increases GlycA levels. Using the prospective data of the same sample of Rotterdam Study in Cox-regression, we show that the circulating GlycA level is a predictive biomarker of COPD incidence (HR = 1.99, 95%CI 1.52–2.60, comparing those in the highest and lowest quartile of GlycA) but is not significantly associated with mortality in COPD patients (HR = 1.07, 95%CI 0.94–1.20).ConclusionsOur study shows that circulating blood GlycA is a biomarker of early COPD pathology.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Lungmedicin och allergi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Respiratory Medicine and Allergy (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine (hsv//eng)
Nyckelord
- COPD
- Metabolomics
- Mendelian randomization
- Glycoprotein acetyls
- Biomarkers
- Hälsa och välfärd
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Prokic, Ivana
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Lahousse, Lies
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de Vries, Maaike
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Liu, Jun
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Kalaoja, Marita
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Vonk, Judith M.
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visa fler...
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van der Plaat, D ...
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van Diemen, Cleo ...
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van der Spek, As ...
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Zhernakova, Alex ...
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Fu, Jingyuan
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Ghanbari, Mohsen
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Ala-Korpela, Mik ...
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Kettunen, Johann ...
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Havulinna, Aki S ...
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Perola, Markus
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Salomaa, Veikko
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Lind, Lars
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Ärnlöv, Johan, 1 ...
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Stricker, Bruno ...
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Brusselle, Guy G ...
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Boezen, H. Marik ...
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van Duijn, Corne ...
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Amin, Najaf
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- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Lungmedicin och ...
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
- Artiklar i publikationen
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BMC Pulmonary Me ...
- Av lärosätet
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Uppsala universitet
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Karolinska Institutet
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Högskolan Dalarna