Reduced intensity conditioning for acute myeloid leukemia using melphalan- vs busulfan-based regimens: a CIBMTR report

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Zhou, ZhengLahey Hosp & Med Ctr, Beth Israel Lahey Hlth, Burlington, MA 01805 USA. (author)

Reduced intensity conditioning for acute myeloid leukemia using melphalan- vs busulfan-based regimens : a CIBMTR report

Article/chapterEnglish2020

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2020-07-14
American Society of Hematology,2020
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LIBRIS-ID:oai:DiVA.org:uu-419793
https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-419793URI
https://doi.org/10.1182/bloodadvances.2019001266DOI
http://kipublications.ki.se/Default.aspx?queryparsed=id:144221407URI

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Language:English
Summary in:English

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SwePubSwePub

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Subject category:ref swepub-contenttype
Subject category:art swepub-publicationtype

Notes

There is a lack of large comparative study on the outcomes of reduced intensity conditioning (RIC) in acute myeloid leukemia (AML) transplantation using fludarabine/busulfan (FB) and fludarabine/melphalan (FM) regimens. Adult AML patients from Center for International Blood and Marrow Transplant Research who received first RIC allo-transplant between 2001 and 2015 were studied. Patients were excluded if they received cord blood or identical twin transplant, total body irradiation in conditioning, or graft-versus-host disease (GVHD) prophylaxis with in vitro T-cell depletion. Primary outcome was overall survival (OS), secondary end points were leukemia-free survival (LFS), nonrelapse mortality (NRM), relapse, and GVHD. Multivariate survival model was used with adjustment for patient, leukemia, and transplant-related factors. A total of 622 patients received FM and 791 received FB RIC. Compared with FB, the FM group had fewer transplant in complete remission (CR), fewer matched sibling donors, and less usage of anti-thymocyte globulin or alemtuzumab. More patients in the FM group received marrow grafts and had transplantation before 2005. OS was significantly lower within the first 3 months posttransplant in the FM group (hazard ratio [HR] = 1.82, P < .001), but was marginally superior beyond 3 months (HR = 0.87, P = .05). LFS was better with FM compared with FB (HR = 0.89, P = .05). NRM was significantly increased in the FM group during the first 3 months of posttransplant (HR = 3.85, P < .001). Long-term relapse was lower with FM (HR = 0.65, P < .001). Analysis restricted to patients with CR showed comparable results. In conclusion, compared with FB, the FM RIC showed a marginally superior long-term OS and LFS and a lower relapse rate. A lower OS early posttransplant within 3 months was largely the result of a higher early NRM.

Subject headings and genre

MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Hematologi hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Hematology hsv//eng

Added entries (persons, corporate bodies, meetings, titles ...)

Nath, RajneeshBanner MD Anderson Canc Ctr, Gilbert, AZ USA. (author)
Cerny, JanUniv Massachusetts, Med Ctr, Dept Med, 3Div Hematol Oncol, Worcester, MA USA. (author)
Wang, Hai-LinMed Coll Wisconsin, Dept Med, Div Hematol Oncol & Blood & Marrow Transplantat, Milwaukee, WI 53226 USA. (author)
Zhang, Mei-JieMed Coll Wisconsin, Dept Med, Div Hematol Oncol & Blood & Marrow Transplantat, Milwaukee, WI 53226 USA.;Med Coll Wisconsin, Inst Hlth & Equ, Div Biostat, Milwaukee, WI 53226 USA. (author)
Abdel-Azim, HishamUniv Southern Calif, Keck Sch Med, Childrens Hosp Los Angeles, Div Hematol Oncol & Blood & Marrow Transplantat, Los Angeles, CA 90007 USA. (author)
Agrawal, VaibhavIndiana Univ Sch Med, Div Hematol Oncol, Indianapolis, IN 46202 USA. (author)
Ahmed, GulrayzMed Coll Wisconsin, Internal Med, Milwaukee, WI 53226 USA. (author)
Al-Homsi, A. SamerNYU, Langone Med Ctr, New York, NY USA. (author)
Aljurf, MahmoudKing Faisal Specialist Hosp & Res Ctr, Dept Oncol, Riyadh, Saudi Arabia. (author)
Alkhateeb, Hassan B.Mayo Clin, Bone Marrow Transplant Program, Rochester, MN USA. (author)
Assal, AmerNYPH Columbia Univ Med Ctr, New York, NY USA. (author)
Bacher, UlrikeUniv Bern, Bern Univ Hosp, Dept Hematol, Inselspital, Bern, Switzerland. (author)
Bajel, AshishRoyal Melbourne Hosp, City Campus, Parkville, Vic, Australia. (author)
Bashir, QaiserUniv Texas MD Anderson Canc Ctr, Dept Stem Cell Transplantat & Cellular Therapy, Div Canc Med, Houston, TX 77030 USA. (author)
Battiwalla, MinocherSarah Cannon Blood Canc Network, Nashville, TN USA. (author)
Bhatt, Vijaya RajUniv Nebraska Med Ctr, Fred & Pamela Buffett Canc Ctr, Omaha, NE USA. (author)
Byrne, MichaelVanderbilt Univ, Med Ctr, Nashville, TN USA. (author)
Cahn, Jean-YvesCtr Hosp Univ Grenoble Alpes, Dept Hematol, Grenoble, France. (author)
Cairo, MitchellNew York Med Coll, Dept Pediat, Div Pediat Hematol Oncol & Stem Cell Transplantat, Valhalla, NY 10595 USA. (author)
Choe, HannahOhio Univ, Wexner Med Ctr, James Comprehens Canc Ctr, Columbus, OH USA. (author)
Copelan, EdwardAtrium Hlth, Dept Hematol Oncol & Blood Disorders, Levine Canc Inst, Charlotte, NC USA. (author)
Cutler, CoreyDana Farber Canc Inst, Ctr Hematol Oncol, Boston, MA 02115 USA. (author)
Damlaj, Moussab B.King Saud Bin Abdulaziz Univ Hlth Sci, King Abdulaziz Med City, King Abdullah Int Med Res Ctr, Riyadh, Saudi Arabia. (author)
DeFilipp, ZachariahMassachusetts Gen Hosp, Blood & Marrow Transplant Program, Boston, MA 02114 USA. (author)
De Lima, MarcosUniv Hosp Case Med Ctr, Seidman Canc Ctr, Dept Med, Cleveland, OH USA. (author)
Diaz, Miguel AngelHosp Infantil Univ Nino Jesus, Dept Hematol Oncol, Madrid, Spain. (author)
Farhadfar, NoshaUniv Florida, Coll Med, Div Hematol Oncol, Gainesville, FL USA. (author)
Foran, JamesMayo Clin, Bone Marrow Transplant Program, Jacksonville, FL 32224 USA. (author)
Freytes, Cesar O.Texas Transplant Inst, San Antonio, TX USA. (author)
Gerds, Aaron T.Cleveland Clin, Taussig Canc Inst, Hematol & Med Oncol, Cleveland, OH 44106 USA. (author)
Gergis, UsamaNew York Presbyterian Hosp, Dept Med Oncol, Hematol Malignancies & Bone Marrow Transplant, Weill Cornell Med Ctr, New York, NY USA. (author)
Grunwald, Michael R.Atrium Hlth, Dept Hematol Oncol & Blood Disorders, Levine Canc Inst, Charlotte, NC USA. (author)
Gul, ZartashUniv Cincinnati, Med Ctr, Cincinnati, OH 45267 USA. (author)
Hamadani, MehdiMed Coll Wisconsin, Dept Med, Div Hematol Oncol & Blood & Marrow Transplantat, Milwaukee, WI 53226 USA. (author)
Hashmi, ShahrukhMayo Clin, Dept Internal Med, Rochester, MN USA.;King Faisal Specialist Hosp & Res Ctr, Oncol Ctr, Riyadh, Saudi Arabia. (author)
Hertzberg, MarkPrince Wales Hosp, Dept Haematol, Randwick, NSW, Australia. (author)
Hildebrandt, Gerhard C.Univ Kentucky, Markey Canc Ctr, Lexington, KY USA. (author)
Hossain, NasheedLoyola Univ Chicago, Stritch Sch Med, Dept Med, Stem Cell Transplant Program,Div Hematol Oncol, Maywood, IL USA. (author)
Inamoto, YoshihiroNatl Canc Ctr, Div Hematopoiet Stem Cell Transplantat, Tokyo, Japan. (author)
Isola, LuisMt Sinai Med Ctr, New York, NY 10029 USA. (author)
Jain, TaniaMem Sloan Kettering Canc Ctr, 1275 York Ave, New York, NY 10021 USA. (author)
Kamble, Rammurti T.Baylor Coll Med, Div Hematol & Oncol, Ctr Cell & Gene Therapy, Houston, TX 77030 USA. (author)
Khan, Muhammad WaqasLouisiana State Univ, Bone Marrow Transplant Program, Div Hematol Oncol, Baton Rouge, LA 70803 USA. (author)
Kharfan-Dabaja, Mohamed A.Mayo Clin, Blood & Marrow Transplantat Program, Div Hematol Oncol, Jacksonville, FL 32224 USA. (author)
Kebriaei, PartowUniv Texas MD Anderson Canc Ctr, Dept Stem Cell Transplantat & Cellular Therapy, Div Canc Med, Houston, TX 77030 USA. (author)
Kekre, NatashaOttawa Hosp Blood & Marrow Transplant Program, Ottawa, ON, Canada. (author)
Khera, NanditaMayo Clin, Dept Hematol Oncol, Phoenix, AZ USA. (author)
Lazarus, Hillard M.Case Western Reserve Univ, Cleveland, OH 44106 USA. (author)
Liesveld, Jane L.Univ Rochester, Med Ctr, Dept Med, Rochester, NY 14642 USA. (author)
Litzow, MarkMayo Clin Rochester, Div Hematol & Transplant Ctr, Rochester, MN USA. (author)
Liu, HongtaoUniv Chicago Med, Chicago, IL USA. (author)
Marks, David, IUniv Hosp Bristol NHS Trust, Adult Bone Marrow Transplant, Bristol, Avon, England. (author)
Martino, RodrigoHosp Santa Creu & Sant Pau, Div Clin Hematol, Barcelona, Spain. (author)
Mathews, VikramChristian Med Coll & Hosp, Vellore, Tamil Nadu, India. (author)
Mishra, AsmitaH Lee Moffitt Canc Ctr & Res Inst, Dept Blood & Marrow Transplant & Cellular Immunot, Tampa, FL USA. (author)
Murthy, Hemant S.Mayo Clin, Blood & Marrow Transplantat Program, Div Hematol Oncol, Jacksonville, FL 32224 USA. (author)
Nagler, ArnonChaim Sheba Med Ctr, Hematol Div, Tel Hashomer, Israel.;Chaim Sheba Med Ctr, BMT, Tel Hashomer, Israel.;Tel Aviv Univ, Div Hematol & Bone Marrow Transplantat, Tel Aviv, Israel.;Tel Aviv Univ, Cord Blood Bank, Tel Aviv, Israel. (author)
Nakamura, RyotaroCity Hope Natl Med Ctr, Dept Hematol & Hematopoiet Cell Transplantat, Duarte, CA USA. (author)
Nathan, SunitaRush Univ, Med Ctr, Chicago, IL 60612 USA. (author)
Nishihori, TaigaH Lee Moffitt Canc Ctr & Res Inst, Dept Blood & Marrow Transplant & Cellular Immunot, Tampa, FL USA. (author)
Olin, RebeccaUniv Calif San Francisco, San Francisco, CA 94143 USA. (author)
Olsson, Richard F.Uppsala universitet,Centrum för klinisk forskning i Sörmland (CKFD),Karolinska Inst, Dept Lab Med, Stockholm, Sweden.(Swepub:uu)riols677 (author)
Palmisiano, NeilThomas Jefferson Univ, Sidney Kimmel Canc Ctr, Philadelphia, PA 19107 USA. (author)
Patel, Sagar S.Univ Utah, Blood & Marrow Transplant Program, Salt Lake City, UT USA. (author)
Patnaik, Mrinal M.Mayo Clin, Bone Marrow Transplant Program, Rochester, MN USA. (author)
Pawarode, AttapholUniv Michigan, Sch Med, Dept Internal Med, Div Hematol Oncol,Blood & Marrow Transplantat Pro, Ann Arbor, MI USA. (author)
Perales, Miguel-AngelMem Sloan Kettering Canc Ctr, Dept Med, Adult Bone Marrow Transplantat Serv, 1275 York Ave, New York, NY 10021 USA. (author)
Politikos, IoannisMem Sloan Kettering Canc Ctr, Dept Med, Adult Bone Marrow Transplantat Serv, 1275 York Ave, New York, NY 10021 USA. (author)
Popat, UdayUniv Texas MD Anderson Canc Ctr, Dept Stem Cell Transplantat & Cellular Therapy, Div Canc Med, Houston, TX 77030 USA. (author)
Rizzieri, DavidDuke Univ, Div Hematol Malignancies & Cellular Therapy, Durham, NC USA. (author)
Sandmaier, Brenda M.Univ Washington, Div Med Oncol, Seattle, WA 98195 USA.;Fred Hutchinson Canc Res Ctr, Clin Res Div, 1124 Columbia St, Seattle, WA 98104 USA. (author)
Savani, Bipin N.Vanderbilt Univ, Med Ctr, Dept Med, Div Hematol Oncol, Nashville, TN USA. (author)
Seo, SachikoDokkyo Med Univ, Dept Haematol & Oncol, Mibu, Tochigi, Japan. (author)
Shah, Nirav N.Med Coll Wisconsin, Dept Med, Milwaukee, WI 53226 USA. (author)
Uy, Geoffrey L.Washington Univ, Sch Med, Div Oncol, St Louis, MO USA. (author)
Valcarcel, DavidHosp Valle De Hebron, Dept Hematol, Barcelona, Spain. (author)
Verdonck, Leo F.Isala Clin, Dept Hematol Oncol, Zwolle, Netherlands. (author)
Waller, Edmund K.Emory Univ, Winship Canc Inst, Dept Hematol & Med Oncol, Atlanta, GA 30322 USA. (author)
Wang, YoujinNCI, NIH, Rockville, MD USA. (author)
Weisdorf, DanielUniv Minnesota, Dept Med, Div Hematol Oncol & Transplantat, Box 736 UMHC, Minneapolis, MN 55455 USA. (author)
Wirk, BaldeepPenn State Canc Inst, Bone Marrow Transplant Program, Hershey, PA USA. (author)
Wong, EricRoyal Melbourne Hosp, City Campus, Parkville, Vic, Australia. (author)
Yared, Jean A.Univ Maryland, Dept Med, Greenebaum Comprehens Canc Ctr, Blood & Marrow Transplantat Program,Div Hematol O, Baltimore, MD 21201 USA. (author)
Saber, WaelMed Coll Wisconsin, Dept Med, Div Hematol Oncol & Blood & Marrow Transplantat, Milwaukee, WI 53226 USA. (author)
Lahey Hosp & Med Ctr, Beth Israel Lahey Hlth, Burlington, MA 01805 USA.Banner MD Anderson Canc Ctr, Gilbert, AZ USA. (creator_code:org_t)

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In:Blood Advances: American Society of Hematology4:13, s. 3180-31902473-95292473-9537

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By the author/editor: Zhou, Zheng; Nath, Rajneesh; Cerny, Jan; Wang, Hai-Lin; Zhang, Mei-Jie; Abdel-Azim, Hish ...; show more...; Agrawal, Vaibhav; Ahmed, Gulrayz; Al-Homsi, A. Sam ...; Aljurf, Mahmoud; Alkhateeb, Hassa ...; Assal, Amer; Bacher, Ulrike; Bajel, Ashish; Bashir, Qaiser; Battiwalla, Mino ...; Bhatt, Vijaya Ra ...; Byrne, Michael; Cahn, Jean-Yves; Cairo, Mitchell; Choe, Hannah; Copelan, Edward; Cutler, Corey; Damlaj, Moussab ...; DeFilipp, Zachar ...; De Lima, Marcos; Diaz, Miguel Ang ...; Farhadfar, Nosha; Foran, James; Freytes, Cesar O ...; Gerds, Aaron T.; Gergis, Usama; Grunwald, Michae ...; Gul, Zartash; Hamadani, Mehdi; Hashmi, Shahrukh; Hertzberg, Mark; Hildebrandt, Ger ...; Hossain, Nasheed; Inamoto, Yoshihi ...; Isola, Luis; Jain, Tania; Kamble, Rammurti ...; Khan, Muhammad W ...; Kharfan-Dabaja, ...; Kebriaei, Partow; Kekre, Natasha; Khera, Nandita; Lazarus, Hillard ...; Liesveld, Jane L ...; Litzow, Mark; Liu, Hongtao; Marks, David, I; Martino, Rodrigo; Mathews, Vikram; Mishra, Asmita; Murthy, Hemant S ...; Nagler, Arnon; Nakamura, Ryotar ...; Nathan, Sunita; Nishihori, Taiga; Olin, Rebecca; Olsson, Richard ...; Palmisiano, Neil; Patel, Sagar S.; Patnaik, Mrinal ...; Pawarode, Attaph ...; Perales, Miguel- ...; Politikos, Ioann ...; Popat, Uday; Rizzieri, David; Sandmaier, Brend ...; Savani, Bipin N.; Seo, Sachiko; Shah, Nirav N.; Uy, Geoffrey L.; Valcarcel, David; Verdonck, Leo F.; Waller, Edmund K ...; Wang, Youjin; Weisdorf, Daniel; Wirk, Baldeep; Wong, Eric; Yared, Jean A.; Saber, Wael; show less...

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