Sökning: WFRF:(Jacobson Leslie) >
Autoantibodies to t...
Autoantibodies to the N-Methyl-D-Aspartate Receptor in Adolescents With Early Onset Psychosis and Healthy Controls
-
- Engen, Kristine (författare)
- Diakonhjemmet Hosp, Dept Psychiat Res, Oslo, Norway.;Univ Oslo, NORMENT, Inst Clin Med, Oslo, Norway.
-
- Wortinger, Laura Anne (författare)
- Diakonhjemmet Hosp, Dept Psychiat Res, Oslo, Norway.;Univ Oslo, NORMENT, Inst Clin Med, Oslo, Norway.
-
- Jorgensen, Kjetil Nordbo (författare)
- Diakonhjemmet Hosp, Dept Psychiat Res, Oslo, Norway.;Univ Oslo, NORMENT, Inst Clin Med, Oslo, Norway.
-
visa fler...
-
- Lundberg, Mathias (författare)
- Karolinska Institutet,Uppsala universitet,Barn- och ungdomspsykiatri,Karolinska Inst, Sodersjukhuset, Dept Clin Sci & Educ, Stockholm, Sweden.
-
- Bohman, Hannes, 1965- (författare)
- Karolinska Institutet,Uppsala universitet,Barn- och ungdomspsykiatri,Karolinska Inst, Sodersjukhuset, Dept Clin Sci & Educ, Stockholm, Sweden.
-
- Smelror, Runar Elle (författare)
- Univ Oslo, NORMENT, Inst Clin Med, Oslo, Norway.
-
- Myhre, Anne Margrethe (författare)
- Univ Oslo, NORMENT, Inst Clin Med, Oslo, Norway.;Oslo Univ Hosp, NORMENT, Div Mental Hlth & Addict, Oslo, Norway.
-
- Jacobson, Leslie (författare)
- Univ Oxford, John Radcliffe Hosp, Nuffield Dept Clin Neurosci, Oxford, England.
-
- Vincent, Angela (författare)
- Univ Oxford, John Radcliffe Hosp, Nuffield Dept Clin Neurosci, Oxford, England.
-
- Agartz, Ingrid (författare)
- Karolinska Institutet
-
visa färre...
-
Diakonhjemmet Hosp, Dept Psychiat Res, Oslo, Norway;Univ Oslo, NORMENT, Inst Clin Med, Oslo, Norway. Barn- och ungdomspsykiatri (creator_code:org_t)
- 2020-07-15
- 2020
- Engelska.
-
Ingår i: Frontiers in Psychiatry. - : Frontiers Media SA. - 1664-0640. ; 11
- Relaterad länk:
-
https://doi.org/10.3...
-
visa fler...
-
https://doi.org/10.1...
-
https://uu.diva-port... (primary) (Raw object)
-
https://www.frontier...
-
https://urn.kb.se/re...
-
https://doi.org/10.3...
-
http://kipublication...
-
visa färre...
Abstract
Ämnesord
Stäng
- Background Autoantibodies to theN-methyl-D-aspartate receptor (NMDAR-Abs) in autoimmune encephalitis have been associated with prominent psychiatric symptoms. The aims of the present study are to identify the prevalence of NMDAR-Abs in adolescents with early onset psychosis disorders (EOP) and healthy controls (HC) and examine its clinical significance. Method Plasma samples were acquired from 46 adolescent EOP patients and 69 age- and sex matched HC, and assessed for the presence of immunoglobulin G NMDAR-Abs. All participants underwent psychiatric evaluation, neurological examination and head magnetic resonance imaging. Results NMDAR-Abs were detected in three of 46 (6.5%) EOP patients and in two of 69 (2.9%) HC. One NMDAR-Abs EOP patient presented with unusual psychopathology and minor T1 weighted lesions of vasculopathological origin located bi-frontally and in the basal ganglia, and had a recent diagnosis of a separate autoimmune disease. One NMDAR-Ab HC displayed a T2 weighted FLAIR hyperintensity lesion in the left frontal lobe. The remaining three NMDAR-Ab participants were two EOP patients without neurological or radiological findings, and one HC without any clinical findings. Conclusions We report that a small number of EOP patients and HC have NMDAR-Abs with a similar frequency in both groups. The presence of the antibodies was not associated with any distinctive clinical or radiological features. Detection of the antibodies had no diagnostic implication, and a positive NMDAR antibody test must be carefully interpreted and reviewed within the individual clinical context.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Psykiatri (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Psychiatry (hsv//eng)
Nyckelord
- early onset psychosis
- NMDAr antibodies
- adolescence
- psychosis
- MRI autoantibodies
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
-
Engen, Kristine
-
Wortinger, Laura ...
-
Jorgensen, Kjeti ...
-
Lundberg, Mathia ...
-
Bohman, Hannes, ...
-
Smelror, Runar E ...
-
visa fler...
-
Myhre, Anne Marg ...
-
Jacobson, Leslie
-
Vincent, Angela
-
Agartz, Ingrid
-
visa färre...
- Om ämnet
-
- MEDICIN OCH HÄLSOVETENSKAP
-
MEDICIN OCH HÄLS ...
-
och Klinisk medicin
-
och Psykiatri
- Artiklar i publikationen
-
Frontiers in Psy ...
- Av lärosätet
-
Uppsala universitet
-
Karolinska Institutet