Search: WFRF:(Brion Marie Jo A) >
The Medical Genome ...
-
Pinese, MarkGarvan Inst Med Res, Sydney, NSW, Australia.;Univ New South Wales, Childrens Canc Inst, Sydney, NSW, Australia.;Univ New South Wales, Fac Med, Sch Womens & Childrens Hlth, Sydney, NSW, Australia.
(author)
The Medical Genome Reference Bank contains whole genome and phenotype data of 2570 healthy elderly
- Article/chapterEnglish2020
Publisher, publication year, extent ...
-
2020-01-23
-
Springer Nature,2020
-
electronicrdacarrier
Numbers
-
LIBRIS-ID:oai:DiVA.org:uu-420897
-
https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-420897URI
-
https://doi.org/10.1038/s41467-019-14079-0DOI
Supplementary language notes
-
Language:English
-
Summary in:English
Part of subdatabase
Classification
-
Subject category:ref swepub-contenttype
-
Subject category:art swepub-publicationtype
Notes
-
Population health research is increasingly focused on the genetic determinants of healthy ageing, but there is no public resource of whole genome sequences and phenotype data from healthy elderly individuals. Here we describe the first release of the Medical Genome Reference Bank (MGRB), comprising whole genome sequence and phenotype of 2570 elderly Australians depleted for cancer, cardiovascular disease, and dementia. We analyse the MGRB for single-nucleotide, indel and structural variation in the nuclear and mitochondrial genomes. MGRB individuals have fewer disease-associated common and rare germline variants, relative to both cancer cases and the gnomAD and UK Biobank cohorts, consistent with risk depletion. Age-related somatic changes are correlated with grip strength in men, suggesting blood-derived whole genomes may also provide a biologic measure of age-related functional deterioration. The MGRB provides a broadly applicable reference cohort for clinical genetics and genomic association studies, and for understanding the genetics of healthy ageing. Healthspan and healthy aging are areas of research with potential socioeconomic impact. Here, the authors present the Medical Genome Reference Bank (MGRB) which consist of over 4,000 individuals aged 70 years and older without a history of the major age-related diseases and report on results from whole-genome sequencing and association analyses.
Subject headings and genre
Added entries (persons, corporate bodies, meetings, titles ...)
-
Lacaze, PaulMonash Univ, Dept Epidemiol & Prevent Med, Melbourne, Vic, Australia.
(author)
-
Rath, Emma M.Garvan Inst Med Res, Sydney, NSW, Australia.
(author)
-
Stone, AndrewGarvan Inst Med Res, Sydney, NSW, Australia.;Univ New South Wales, Childrens Canc Inst, Sydney, NSW, Australia.;Univ New South Wales, Fac Med, Sch Womens & Childrens Hlth, Sydney, NSW, Australia.;Univ New South Wales, Fac Med, St Vincents Clin Sch, Sydney, NSW, Australia.
(author)
-
Brion, Marie-JoGarvan Inst Med Res, Sydney, NSW, Australia.
(author)
-
Ameur, AdamUppsala universitet,Institutionen för immunologi, genetik och patologi,Science for Life Laboratory, SciLifeLab,Monash Univ, Dept Epidemiol & Prevent Med, Melbourne, Vic, Australia.(Swepub:uu)adame789
(author)
-
Nagpal, SiniGeorgia Inst Technol, Ctr Integrat Genom, Atlanta, GA 30332 USA.
(author)
-
Puttick, ClareGarvan Inst Med Res, Sydney, NSW, Australia.
(author)
-
Husson, ShaneGarvan Inst Med Res, Sydney, NSW, Australia.
(author)
-
Degrave, DmitryGarvan Inst Med Res, Sydney, NSW, Australia.
(author)
-
Cristina, Tina NavinSax Inst, Sydney, NSW, Australia.
(author)
-
Kahl, Vivian F. S.Univ Sydney, Fac Med & Hlth, Childrens Med Res Inst, Westmead, NSW, Australia.
(author)
-
Statham, Aaron L.Garvan Inst Med Res, Sydney, NSW, Australia.
(author)
-
Woods, Robyn L.Monash Univ, Dept Epidemiol & Prevent Med, Melbourne, Vic, Australia.
(author)
-
McNeil, John J.Monash Univ, Dept Epidemiol & Prevent Med, Melbourne, Vic, Australia.
(author)
-
Riaz, MoeenMonash Univ, Dept Epidemiol & Prevent Med, Melbourne, Vic, Australia.
(author)
-
Barr, MargoUniv New South Wales, Ctr Primary Hlth Care & Equ, Sydney, NSW, Australia.
(author)
-
Nelson, Mark R.Monash Univ, Dept Epidemiol & Prevent Med, Melbourne, Vic, Australia.;Univ Tasmania, Menzies Inst Med Res, Hobart, Tas, Australia.
(author)
-
Reid, Christopher M.Monash Univ, Dept Epidemiol & Prevent Med, Melbourne, Vic, Australia.;Curtin Univ, Sch Publ Hlth, Perth, WA, Australia.
(author)
-
Murray, Anne M.Berman Ctr Outcomes & Clin Res, Hennepin Healthcare Res Inst, Hennepin Healthcare, Minneapolis, MN USA.;Hennepin Cty Med Ctr, Dept Med, Div Geriatr, Minneapolis, MN USA.;Univ Minnesota, Minneapolis, MN USA.
(author)
-
Shah, Raj C.Rush Univ, Dept Family Med, Med Ctr, Chicago, IL USA.;Rush Univ, Rush Alzheimers Dis Ctr, Med Ctr, Chicago, IL USA.
(author)
-
Wolfe, RoryMonash Univ, Dept Epidemiol & Prevent Med, Melbourne, Vic, Australia.
(author)
-
Atkins, Joshua R.Univ Newcastle, Sch Biomed Sci & Pharm, Callaghan, NSW, Australia.;Hunter Med Res Inst, Ctr Brain & Mental Hlth Res, Newcastle, NSW, Australia.
(author)
-
Fitzsimmons, ChantelUniv Newcastle, Sch Biomed Sci & Pharm, Callaghan, NSW, Australia.;Hunter Med Res Inst, Ctr Brain & Mental Hlth Res, Newcastle, NSW, Australia.
(author)
-
Cairns, Heath M.Univ Newcastle, Sch Biomed Sci & Pharm, Callaghan, NSW, Australia.;Hunter Med Res Inst, Ctr Brain & Mental Hlth Res, Newcastle, NSW, Australia.
(author)
-
Green, Melissa J.Univ New South Wales, Sch Psychiat, Sydney, NSW, Australia.;Neurosci Res Australia, Sydney, NSW, Australia.
(author)
-
Carr, Vaughan J.Univ New South Wales, Sch Psychiat, Sydney, NSW, Australia.;Neurosci Res Australia, Sydney, NSW, Australia.;Monash Univ, Sch Clin Sci, Dept Psychiat, Melbourne, Vic, Australia.
(author)
-
Cowley, Mark J.Garvan Inst Med Res, Sydney, NSW, Australia.;Univ New South Wales, Childrens Canc Inst, Sydney, NSW, Australia.;Univ New South Wales, Fac Med, Sch Womens & Childrens Hlth, Sydney, NSW, Australia.
(author)
-
Pickett, Hilda A.Univ Sydney, Fac Med & Hlth, Childrens Med Res Inst, Westmead, NSW, Australia.
(author)
-
James, Paul A.Peter MacCallum Canc Ctr, Parkville Familial Canc Ctr, Melbourne, Vic, Australia.;Univ Melbourne, Sir Peter MacCallum Dept Oncol, Melbourne, Vic, Australia.
(author)
-
Powell, Joseph E.Univ New South Wales, Sch Med Sci, UNSW Cellular Genom Futures Inst, Sydney, NSW, Australia.;Garvan Inst Med Res, Garvan Weizmann Ctr Cellular Genom, Sydney, NSW, Australia.
(author)
-
Kaplan, WarrenGarvan Inst Med Res, Sydney, NSW, Australia.;Univ New South Wales, Fac Med, St Vincents Clin Sch, Sydney, NSW, Australia.
(author)
-
Gibson, GregGeorgia Inst Technol, Ctr Integrat Genom, Atlanta, GA 30332 USA.
(author)
-
Gyllensten, Ulf B.Uppsala universitet,Science for Life Laboratory, SciLifeLab,Medicinsk genetik och genomik(Swepub:uu)ulfgyll
(author)
-
Cairns, Murray J.Univ Newcastle, Sch Biomed Sci & Pharm, Callaghan, NSW, Australia.;Hunter Med Res Inst, Ctr Brain & Mental Hlth Res, Newcastle, NSW, Australia.
(author)
-
McNamara, MartinSax Inst, Sydney, NSW, Australia.
(author)
-
Dinger, Marcel E.Garvan Inst Med Res, Sydney, NSW, Australia.;Univ New South Wales, Fac Sci, Sch Biotechnol & Biomol Sci, Sydney, NSW, Australia.
(author)
-
Thomas, David M.Garvan Inst Med Res, Sydney, NSW, Australia.;Univ New South Wales, Fac Med, St Vincents Clin Sch, Sydney, NSW, Australia.
(author)
-
Garvan Inst Med Res, Sydney, NSW, Australia.;Univ New South Wales, Childrens Canc Inst, Sydney, NSW, Australia.;Univ New South Wales, Fac Med, Sch Womens & Childrens Hlth, Sydney, NSW, Australia.Monash Univ, Dept Epidemiol & Prevent Med, Melbourne, Vic, Australia.
(creator_code:org_t)
Related titles
-
In:Nature Communications: Springer Nature11:12041-1723
Internet link
Find in a library
To the university's database
- By the author/editor
-
Pinese, Mark
-
Lacaze, Paul
-
Rath, Emma M.
-
Stone, Andrew
-
Brion, Marie-Jo
-
Ameur, Adam
-
show more...
-
Nagpal, Sini
-
Puttick, Clare
-
Husson, Shane
-
Degrave, Dmitry
-
Cristina, Tina N ...
-
Kahl, Vivian F. ...
-
Statham, Aaron L ...
-
Woods, Robyn L.
-
McNeil, John J.
-
Riaz, Moeen
-
Barr, Margo
-
Nelson, Mark R.
-
Reid, Christophe ...
-
Murray, Anne M.
-
Shah, Raj C.
-
Wolfe, Rory
-
Atkins, Joshua R ...
-
Fitzsimmons, Cha ...
-
Cairns, Heath M.
-
Green, Melissa J ...
-
Carr, Vaughan J.
-
Cowley, Mark J.
-
Pickett, Hilda A ...
-
James, Paul A.
-
Powell, Joseph E ...
-
Kaplan, Warren
-
Gibson, Greg
-
Gyllensten, Ulf ...
-
Cairns, Murray J ...
-
McNamara, Martin
-
Dinger, Marcel E ...
-
Thomas, David M.
-
show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Basic Medicine
-
and Medical Genetics
- Articles in the publication
-
Nature Communica ...
- By the university
-
Uppsala University