Vascular Supply of the Human Spiral Ganglion: Novel Three-Dimensional Analysis Using Synchrotron Phase-Contrast Imaging and Histology

Mei, XueshuangUppsala universitet,Öron-, näs- och halssjukdomar,Peking Univ, Shenzhen Hosp, Dept Otolaryngol, Shenzhen, Peoples R China. (author)

Vascular Supply of the Human Spiral Ganglion : Novel Three-Dimensional Analysis Using Synchrotron Phase-Contrast Imaging and Histology

These authors share last authorship: Hanif M. Ladak, Sumit K. Agrawal and Helge Rask-Andersen.
Human spiral ganglion (HSG) cell bodies located in the bony cochlea depend on a rich vascular supply to maintain excitability. These neurons are targeted by cochlear implantation (CI) to treat deafness, and their viability is critical to ensure successful clinical outcomes. The blood supply of the HSG is difficult to study due to its helical structure and encasement in hard bone. The objective of this study was to present the first three-dimensional (3D) reconstruction and analysis of the HSG blood supply using synchrotron radiation phase-contrast imaging (SR-PCI) in combination with histological analyses of archival human cochlear sections. Twenty-six human temporal bones underwent SR-PCI. Data were processed using volume-rendering software, and a representative three-dimensional (3D) model was created to allow visualization of the vascular anatomy. Histologic analysis was used to verify the segmentations. Results revealed that the HSG is supplied by radial vascular twigs which are separate from the rest of the inner ear and encased in bone. Unlike with most organs, the arteries and veins in the human cochlea do not follow the same conduits. There is a dual venous outflow and a modiolar arterial supply. This organization may explain why the HSG may endure even in cases of advanced cochlear pathology.

Glueckert, RudolfMed Univ Innsbruck, Dept Otolaryngol, Anichstr 35, A-6020 Innsbruck, Austria. (author)
Schrott-Fischer, AnneliesMed Univ Innsbruck, Dept Otolaryngol, Anichstr 35, A-6020 Innsbruck, Austria. (author)
Li, Hao,1984-Uppsala universitet,Öron-, näs- och halssjukdomar(Swepub:uu)haoli805 (author)
Ladak, Hanif M.Western Univ, Dept Med Biophys, Dept Otolaryngol Head & Neck Surg, London, ON, Canada.;Western Univ, Dept Otolaryngol Head & Neck Surg, London, ON, Canada. (author)
Agrawal, Sumit K.Western Univ, Dept Elect & Comp Engn, London, ON, Canada.;Western Univ, Dept Otolaryngol Head & Neck Surg, London, ON, Canada. (author)
Rask-Andersen, HelgeUppsala universitet,Öron-, näs- och halssjukdomar,Western Univ, Dept Otolaryngol Head & Neck Surg, London, ON, Canada.(Swepub:uu)helgraan (author)
Uppsala universitetÖron-, näs- och halssjukdomar (creator_code:org_t)

By the author/editor: Mei, Xueshuang; Glueckert, Rudol ...; Schrott-Fischer, ...; Li, Hao, 1984-; Ladak, Hanif M.; Agrawal, Sumit K ...; show more...; Rask-Andersen, H ...; show less...

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ENGINEERING AND TECHNOLOGY: ENGINEERING AND ...; and Medical Engineer ...; and Medical Image Pr ...

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