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Hormonal determinan...
Hormonal determinants of mammographic density and density change
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- Gabrielson, Marike (author)
- Karolinska Institutet
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- Azam, Shadi (author)
- Karolinska Institutet
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- Hardell, Elina (author)
- Karolinska Inst, Dept Med Epidemiol & Biostat, Nobels Vag 12A, SE-17177 Stockholm, Sweden.
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- Holm, Madeleine (author)
- Karolinska Inst, Dept Med Epidemiol & Biostat, Nobels Vag 12A, SE-17177 Stockholm, Sweden.
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- Ubhayasekera, Kumari (author)
- Uppsala universitet,Analytisk kemi
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- Eriksson, Mikael (author)
- Karolinska Institutet
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- Backlund, Magnus (author)
- Karolinska Institutet
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- Bergquist, Jonas (author)
- Uppsala universitet,Analytisk kemi
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- Czene, Kamila (author)
- Karolinska Institutet
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- Hall, Per (author)
- Karolinska Institutet
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Karolinska Institutet Karolinska Inst, Dept Med Epidemiol & Biostat, Nobels Vag 12A, SE-17177 Stockholm, Sweden (creator_code:org_t)
- 2020-08-26
- 2020
- English.
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In: Breast Cancer Research. - : BMC. - 1465-5411 .- 1465-542X. ; 22:1
- Related links:
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https://doi.org/10.1...
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https://uu.diva-port... (primary) (Raw object)
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https://breast-cance...
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Abstract
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- Background Mammographic density (MD) is a strong risk factor for breast cancer. We examined how endogenous plasma hormones are associated with average MD area (cm(2)) and annual MD change (cm(2)/year). Methods This study within the prospective KARMA cohort included analyses of plasma hormones of 1040 women. Hormones from the progestogen (n = 3), androgen (n = 7), oestrogen (n = 2) and corticoid (n = 5) pathways were analysed by ultra-performance supercritical fluid chromatography-tandem mass spectrometry (UPSFC-MS/MS), as well as peptide hormones and proteins (n = 2). MD was measured as a dense area using the STRATUS method (mean over the left and right breasts) and mean annual MD change over time. Results Greater baseline mean MD was associated with overall higher concentrations of progesterone (average + 1.29 cm(2)per doubling of hormone concentration), 17OH-progesterone (+ 1.09 cm(2)), oesterone sulphate (+ 1.42 cm(2)), prolactin (+ 2.11 cm(2)) and SHBG (+ 4.18 cm(2)), and inversely associated with 11-deoxycortisol (- 1.33 cm(2)). The association between MD and progesterone was confined to the premenopausal women only. The overall annual MD change was - 0.8 cm(2). Hormones from the androgen pathway were statistically significantly associated with MD change. The annual MD change was - 0.96 cm(2)and - 1.16 cm(2)lesser, for women in the highest quartile concentrations of testosterone and free testosterone, respectively, compared to those with the lowest concentrations. Conclusions Our results suggest that, whereas hormones from the progestogen, oestrogen and corticoid pathways drive baseline MD, MD change over time is mainly driven by androgens. This study emphasises the complexity of risk factors for breast cancer and their mechanisms of action.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Reproduktionsmedicin och gynekologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Obstetrics, Gynaecology and Reproductive Medicine (hsv//eng)
Keyword
- Mammographic density
- Mammographic density change
- Plasma hormones
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Gabrielson, Mari ...
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Azam, Shadi
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Hardell, Elina
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Holm, Madeleine
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Ubhayasekera, Ku ...
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Eriksson, Mikael
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Backlund, Magnus
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Bergquist, Jonas
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Czene, Kamila
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Hall, Per
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cancer and Oncol ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Obstetrics Gynae ...
- Articles in the publication
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Breast Cancer Re ...
- By the university
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Uppsala University
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Karolinska Institutet