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Concurrence of elev...
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Kalm-Stephens, Pia,1959-Uppsala universitet,Pediatrisk inflammations- och metabolismforskning samt barnhälsa
(author)
Concurrence of elevated FeNO and airway hyperresponsiveness in nonasthmatic adolescents
- Article/chapterEnglish2020
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2020-01-15
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Wiley,2020
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LIBRIS-ID:oai:DiVA.org:uu-421290
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-421290URI
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https://doi.org/10.1002/ppul.24578DOI
Supplementary language notes
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Language:English
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Summary in:English
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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OBJECTIVES: The aim of this study was to investigate airway responsiveness and eosinophil and neutrophil inflammatory markers in clinically confirmed nonasthmatic adolescents with elevated fractional exhaled nitric oxide (FeNO), a marker of type-2 inflammation in the airways.METHODOLOGY: A total of 959 subjects from a general population, aged 12 to 15 years, answered a standardised questionnaire and underwent FeNO measurements at a screening visit at school. Adolescents without asthma, who had elevated FeNO (FeNO100 > 15 ppb) (n = 19), and control subjects, with low FeNO (FeNO100 < 5 ppb) and without reported symptoms of asthma or allergy (n = 28), participated in a follow-up study where FeNO50 , airway responsiveness to methacholine (PD20 ), blood eosinophil counts, and serum neutrophil lipocalin (HNL) and myeloperoxidase (MPO) levels were measured. Questionnaire follow-ups were performed 4 and 16 years later.RESULTS: Airway responsiveness (PD20 : 6.94 [1.87, 11.39] vs 11.42 [6.33, 59.4] µmol; P < .05) and blood eosinophil counts (0.31 [0.20, 0.44] vs 0.13 [0.1, 0.22] 109 /L; P < .001) (geometric mean [95% CI]) were higher among cases than controls. A significant correlation between blood eosinophils and FeNO was found (rho = 0.41; P = .005). In contrast, serum HNL and MPO were lower in cases than controls (P < .05 both), and there was a negative correlation between HNL and FeNO (r = -0.31; P = .04). At both follow-ups, a higher proportion of subjects reported allergic symptoms compared with baseline (P = .02, P = .01).CONCLUSIONS: Elevated FeNO in nonasthmatic adolescents was associated with airway hyperresponsiveness, elevated blood eosinophil counts, and lower systemic activation of neutrophils.
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Malinovschi, Andrei,1978-Uppsala universitet,Klinisk fysiologi(Swepub:uu)anmal535
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Janson, ChristerUppsala universitet,Lung- allergi- och sömnforskning(Swepub:uu)chrisjn
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Venge, PerUppsala universitet,Klinisk kemi(Swepub:uu)pervenge
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Nordvall, LennartUppsala universitet,Pediatrisk inflammations- och metabolismforskning samt barnhälsa(Swepub:uu)lennnord
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Alving, Kjell,1959-Uppsala universitet,Pediatrisk inflammations- och metabolismforskning samt barnhälsa(Swepub:uu)kjeal631
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Uppsala universitetPediatrisk inflammations- och metabolismforskning samt barnhälsa
(creator_code:org_t)
Related titles
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In:Pediatric Pulmonology: Wiley55:3, s. 571-5798755-68631099-0496
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