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Role of HLA-DP Expr...
Role of HLA-DP Expression in Graft-Versus-Host Disease After Unrelated Donor Transplantation
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- Petersdorf, Effie W. (författare)
- Fred Hutchinson Canc Res Ctr, Div Clin Res, 1124 Columbia St, Seattle, WA 98104 USA.;Univ Washington, Dept Med, Seattle, WA USA.
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- Bengtsson, Mats (författare)
- Uppsala universitet,Klinisk immunologi
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- De Santis, Dianne (författare)
- Fiona Stanley Hosp, PathWest, Perth, WA, Australia.
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- Dubois, Valerie (författare)
- Etab Francais Sang Auvergne Rhone Alpes, Site Lyon, Decines Charpieu, France.
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- Fleischhauer, Katharina (författare)
- Univ Duisburg Essen, Inst Expt Cellular Therapy, Essen, Germany.
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- Gooley, Ted (författare)
- Fred Hutchinson Canc Res Ctr, Div Clin Res, 1124 Columbia St, Seattle, WA 98104 USA.
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- Horowitz, Mary (författare)
- Ctr Int Blood & Marrow Transplant Res, Milwaukee, WI USA.;Med Coll Wisconsin, Div Hematol & Oncol, Milwaukee, WI 53226 USA.
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- Madrigal, J. Alejandro (författare)
- Royal Free Hosp, Anthony Nolan Res Inst, London, England.
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- Malkki, Mari (författare)
- Fred Hutchinson Canc Res Ctr, Div Clin Res, 1124 Columbia St, Seattle, WA 98104 USA.
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- McKallor, Caroline (författare)
- Fred Hutchinson Canc Res Ctr, Div Clin Res, 1124 Columbia St, Seattle, WA 98104 USA.
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- Morishima, Yasuo (författare)
- Aichi Med Univ, Sch Med, Nagakute, Aichi, Japan.
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- Oudshoorn, Machteld (författare)
- Leiden Univ, Dept Immunohematol & Blood Transfus, Med Ctr, Leiden, Netherlands.;Matchis Fdn, Leiden, Netherlands.
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- Spellman, Stephen R. (författare)
- Ctr Int Blood & Marrow Transplant Res, Minneapolis, MN USA.
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- Villard, Jean (författare)
- Geneva Univ Hosp, Geneva, Switzerland.
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- Stevenson, Phil (författare)
- Fred Hutchinson Canc Res Ctr, Div Clin Res, 1124 Columbia St, Seattle, WA 98104 USA.
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- Carrington, Mary (författare)
- Frederick Natl Lab Canc Res, Basic Sci Program, Frederick, MD USA.;MIT, Massachusetts Gen Hosp, Ragon Inst, 77 Massachusetts Ave, Cambridge, MA 02139 USA.;Harvard Univ, Cambridge, MA 02138 USA.
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Fred Hutchinson Canc Res Ctr, Div Clin Res, 1124 Columbia St, Seattle, WA 98104 USA;Univ Washington, Dept Med, Seattle, WA USA. Klinisk immunologi (creator_code:org_t)
- American Society of Clinical Oncology (ASCO), 2020
- 2020
- Engelska.
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Ingår i: Journal of Clinical Oncology. - : American Society of Clinical Oncology (ASCO). - 0732-183X .- 1527-7755. ; 38:24, s. 2712-2718
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
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- PURPOSE The main aim of this study was to evaluate the significance of HLA-DPB1 expression in acute graft-versus-host disease (GVHD) after hematopoietic cell transplantation (HCT) from HLA-A, -B, -C, -DRB1, -DQB1-matched and -mismatched unrelated donors. PATIENTS AND METHODS Between January 1, 2017, and January 10, 2019, we assessed 19,136 patients who received HCT from an HLA-A, -B, -C, -DRB1, -DQB1-matched or -mismatched unrelated donor performed in Australia, the European Union, Japan, North America, and the United Kingdom between 1988 and 2016. Among transplant recipients with one HLA-DPB1 mismatch, the patient's mismatched HLA-DPB1 allotype was defined as low or high expression. Multivariable regression models were used to assess risks of GVHD associated with high expression relative to low expression HLA-DPB1 mismatches. The effect of increasing numbers of HLA-DPB1 mismatches on clinical outcome was assessed in HLA-mismatched transplant recipients. RESULTS In HLA-A, -B, -C, -DRB1,-DQB1-matched transplant recipients, donor mismatching against one high-expression patient HLA-DPB1 increased moderate (odds ratio [OR], 1.36; P = .001) and severe acute GVHD (OR, 1.32; P = .0016) relative to low-expression patient mismatches, regardless of the expression level of the donor's mismatched HLA-DPB1. Among transplant recipients with one HLA-A, -B, -C, -DRB1, or -DQB1 mismatch, the odds of acute GVHD increased with increasing numbers of HLA-DPB1 mismatches (OR, 1.23 for one; OR, 1.40 for two mismatches relative to zero mismatches for moderate GVHD; OR, 1.19 for one; OR, 1.40 for two mismatches relative to zero for severe GVHD), but not with the level of expression of the patient's mismatched HLA-DPB1 allotype. CONCLUSION The level of expression of patient HLA-DPB1 mismatches informs the risk of GVHD after HLA-A, -B, -C, -DRB1, -DQB1-matched unrelated HCT, and the total number of HLA-DPB1 mismatches informs the risk of GVHD after HLA-mismatched unrelated HCT. Prospective consideration of HLA-DPB1 may help to lower GVHD risks after transplantation.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
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Petersdorf, Effi ...
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Bengtsson, Mats
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De Santis, Diann ...
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Dubois, Valerie
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Fleischhauer, Ka ...
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Gooley, Ted
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Horowitz, Mary
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Madrigal, J. Ale ...
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Malkki, Mari
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McKallor, Caroli ...
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Morishima, Yasuo
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Oudshoorn, Macht ...
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Spellman, Stephe ...
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Villard, Jean
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Stevenson, Phil
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Carrington, Mary
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