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Sökning: id:"swepub:oai:DiVA.org:uu-421528" > The impact of local...

  • Sparber-Sauer, MonikaKlinikum Stuttgart Olgahosp, Stuttgart Canc Ctr, Zentrum Kinder Jugend & Frauenmed, Pediat Oncol Hematol Immunol 5, Stuttgart, Germany. (författare)

The impact of local control in the treatment of children with advanced infantile and adult-type fibrosarcoma : Experience of the cooperative weichteilsarkom studiengruppe (CWS)

  • Artikel/kapitelEngelska2020

Förlag, utgivningsår, omfång ...

  • W B SAUNDERS CO-ELSEVIER INC,2020
  • printrdacarrier

Nummerbeteckningar

  • LIBRIS-ID:oai:DiVA.org:uu-421528
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-421528URI
  • https://doi.org/10.1016/j.jpedsurg.2019.10.051DOI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • Background and objectives: This study aims at examining the potential survival benefits of primary versus secondary surgery of children diagnosed with advanced infantile (iFS) and adult-type fibrosarcoma (aFS). Methods: Treatment and outcome of 89 children with FS treated within prospective Cooperative Studiengruppe (CWS) trials (1981-2016) were analyzed retrospectively. Results: Localized disease (LD) was diagnosed in 87 patients: 64/66 patients with iFS (<= 2 years) and 23 with aFS (>2 <= 18 years). Two patients (iFS) had metastatic disease. Resection was the mainstay of therapy of patients with LD resulting in microscopically complete (R0, IRS group I) (n = 29/87, 33%), microscopically incomplete (R1, IRS group II) (n = 17/87, 20%) and macroscopically incomplete (R2, IRS group III) (n = 41/87, 47%). Advanced LD (IRS group Ill) was present in 32/64 (50%) palieras with iFS and in 9/23 (39%) with aFS. Chemotherapy was added predominantly in patients with advanced disease and an assessable objective response to CHT was seen in 71% iFS and 75% aFS. The 5 -year event-free survival (EFS) of patients with iFS and aFS was 81% (+/- 10, 95% Cl) and 70% (+/- 19, 95% Cl) (p = 0.24); the 5 -year overall survival (OS) was 98% (+/- 3, 95% Cl) and 82% (+/- 16, 95% Cl) (p = 0.02). Primary resection was no prognostic factor. Secondary R0/R1 resection in patients with advanced disease improved 5-year EFS and OS in aFS (p = 0.002 and p = 0.000) but not in infants. Conclusions: Secondary resection improves outcome in advanced aFS but not in infants. Mutilating surgery in infants should be avoided. (C) 2019 Elsevier Inc. All rights reserved.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Vokuhl, ChristianKiel Pediat Tumor Registry, Sect Pediat Pathol, Dept Pathol, Kiel, Germany. (författare)
  • Seitz, GuidoUniv Childrens Hosp Marburg, Dept Pediat Surg, Marburg, Germany. (författare)
  • Stegmaier, SabineKlinikum Stuttgart Olgahosp, Stuttgart Canc Ctr, Zentrum Kinder Jugend & Frauenmed, Pediat Oncol Hematol Immunol 5, Stuttgart, Germany. (författare)
  • Hallmen, ErikaKlinikum Stuttgart Olgahosp, Stuttgart Canc Ctr, Zentrum Kinder Jugend & Frauenmed, Pediat Oncol Hematol Immunol 5, Stuttgart, Germany. (författare)
  • von Kalle, TheklaKlinikum Stuttgart Olgahosp, Stuttgart Canc Ctr, Zentrum Kinder Jugend & Frauenmed, Olgahosp,Inst Radiol, Stuttgart, Germany. (författare)
  • Scheer, MonikaKlinikum Stuttgart Olgahosp, Stuttgart Canc Ctr, Zentrum Kinder Jugend & Frauenmed, Pediat Oncol Hematol Immunol 5, Stuttgart, Germany. (författare)
  • Muenter, MarcKlinikum Stuttgart, Inst Radiotherapy, Stuttgart, Germany. (författare)
  • Bielack, Stefan S.Klinikum Stuttgart Olgahosp, Stuttgart Canc Ctr, Zentrum Kinder Jugend & Frauenmed, Pediat Oncol Hematol Immunol 5, Stuttgart, Germany.;Univ Munster, Dept Pediat Hematol & Oncol, Munster, Germany. (författare)
  • Ladenstein, RuthSt Anna Childrens Hosp, Pediat Oncol, Vienna, Austria. (författare)
  • Niggli, FelixUniv Zurich, Dept Pediat Oncol, Zurich, Switzerland. (författare)
  • Ljungman, Gustaf,1958-Uppsala universitet,Institutionen för kvinnors och barns hälsa(Swepub:uu)gustaflm (författare)
  • Fuchs, JoergUniv Childrens Hosp, Dept Pediat Surg & Urol, Tubingen, Germany. (författare)
  • Klingebiel, ThomasGoethe Univ, Univ Frankfurt, Dept Children & Adolescents, Frankfurt, Germany. (författare)
  • Koscielniak, EwaKlinikum Stuttgart Olgahosp, Stuttgart Canc Ctr, Zentrum Kinder Jugend & Frauenmed, Pediat Oncol Hematol Immunol 5, Stuttgart, Germany.;Goethe Univ, Univ Frankfurt, Dept Children & Adolescents, Frankfurt, Germany. (författare)
  • Klinikum Stuttgart Olgahosp, Stuttgart Canc Ctr, Zentrum Kinder Jugend & Frauenmed, Pediat Oncol Hematol Immunol 5, Stuttgart, Germany.Kiel Pediat Tumor Registry, Sect Pediat Pathol, Dept Pathol, Kiel, Germany. (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:Journal of Pediatric Surgery: W B SAUNDERS CO-ELSEVIER INC55:9, s. 1740-17470022-34681531-5037

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