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  • Accordini, SimoneUniv Verona, Dept Diagnost & Publ Hlth, Unit Epidemiol & Med Stat, Verona, Italy. (författare)

Incidence trends of airflow obstruction among European adults without asthma : a 20-year cohort study

  • Artikel/kapitelEngelska2020

Förlag, utgivningsår, omfång ...

  • 2020-02-26
  • NATURE PUBLISHING GROUP,2020
  • electronicrdacarrier

Nummerbeteckningar

  • LIBRIS-ID:oai:DiVA.org:uu-421543
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-421543URI
  • https://doi.org/10.1038/s41598-020-60478-5DOI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • Investigating COPD trends may help healthcare providers to forecast future disease burden. We estimated sex- and smoking-specific incidence trends of pre-bronchodilator airflow obstruction (AO) among adults without asthma from 11 European countries within a 20-year follow-up (ECRHS and SAPALDIA cohorts). We also quantified the extent of misclassification in the definition based on pre-bronchodilator spirometry (using post-bronchodilator measurements from a subsample of subjects) and we used this information to estimate the incidence of post-bronchodilator AO (AO(post-BD)), which is the primary characteristic of COPD. AO incidence was 4.4 (95% CI: 3.5-5.3) male and 3.8 (3.1-4.6) female cases/1,000/year. Among ever smokers (median pack-years: 20, males; 12, females), AO incidence significantly increased with ageing in men only [incidence rate ratio (IRR), 1-year increase: 1.05 (1.03-1.07)]. A strong exposure-response relationship with smoking was found both in males [IRR, 1-pack-year increase: 1.03 (1.02-1.04)] and females [1.03 (1.02-1.05)]. The positive predictive value of AO for AO(post-BD) was 59.1% (52.0-66.2%) in men and 42.6% (35.1-50.1%) in women. AO(post-BD) incidence was 2.6 (1.7-3.4) male and 1.6 (1.0-2.2) female cases/1,000/year. AO incidence was considerable in Europe and the sex-specific ageing-related increase among ever smokers was strongly related to cumulative tobacco exposure. AO(post-BD) incidence is expected to be half of AO incidence.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Calciano, LuciaUniv Verona, Dept Diagnost & Publ Hlth, Unit Epidemiol & Med Stat, Verona, Italy. (författare)
  • Marcon, AlessandroUniv Verona, Dept Diagnost & Publ Hlth, Unit Epidemiol & Med Stat, Verona, Italy. (författare)
  • Pesce, GiancarloUniv Verona, Dept Diagnost & Publ Hlth, Unit Epidemiol & Med Stat, Verona, Italy.;Sorbonne Univ, INSERM, UMR S 1136, IPLESP,Team EPAR, F-75012 Paris, France. (författare)
  • Ant, Josep M.Ctr Res Environm Epidemiol CREAL, ISGlobal, Barcelona, Spain.;Hosp del Mar Med Res Inst IMIM, Barcelona, Spain.;CIBER Epidemiol & Salud Publ CIBERESP, Barcelona, Spain.;Univ Pompeu Fabra UPF, Barcelona, Spain. (författare)
  • Beckmeyer-Borowko, Anna B.Swiss Trop & Publ Hlth Inst, Dept Epidemiol & Publ Hlth, Basel, Switzerland.;Univ Basel, Basel, Switzerland. (författare)
  • Carsin, Anne-ElieCtr Res Environm Epidemiol CREAL, ISGlobal, Barcelona, Spain.;CIBER Epidemiol & Salud Publ CIBERESP, Barcelona, Spain.;Univ Pompeu Fabra UPF, Barcelona, Spain. (författare)
  • Corsico, Angelo G.Univ Pavia, San Matteo Hosp Fdn, IRCCS, Div Resp Dis, Pavia, Italy. (författare)
  • Imboden, MedeaSwiss Trop & Publ Hlth Inst, Dept Epidemiol & Publ Hlth, Basel, Switzerland.;Univ Basel, Basel, Switzerland. (författare)
  • Janson, ChristerUppsala universitet,Lung- allergi- och sömnforskning(Swepub:uu)chrisjn (författare)
  • Keidel, DirkSwiss Trop & Publ Hlth Inst, Dept Epidemiol & Publ Hlth, Basel, Switzerland.;Univ Basel, Basel, Switzerland. (författare)
  • Locatelli, FrancescaUniv Verona, Dept Diagnost & Publ Hlth, Unit Epidemiol & Med Stat, Verona, Italy. (författare)
  • Svanes, CecilieUniv Bergen, Dept Global Publ Hlth & Primary Care, Ctr Int Hlth, Bergen, Norway.;Haukeland Hosp, Dept Occupat Med, Bergen, Norway. (författare)
  • Burney, Peter G. J.Imperial Coll London, Natl Heart & Lung Inst, Populat Hlth & Occupat Dis, London, England.;Imperial Coll London, MRC PHE Ctr Environm & Hlth, London, England. (författare)
  • Jarvis, DeborahImperial Coll London, Natl Heart & Lung Inst, Populat Hlth & Occupat Dis, London, England.;Imperial Coll London, MRC PHE Ctr Environm & Hlth, London, England. (författare)
  • Probst-Hensch, Nicole M.Swiss Trop & Publ Hlth Inst, Dept Epidemiol & Publ Hlth, Basel, Switzerland.;Univ Basel, Basel, Switzerland. (författare)
  • Minelli, CosettaImperial Coll London, Natl Heart & Lung Inst, Populat Hlth & Occupat Dis, London, England. (författare)
  • Univ Verona, Dept Diagnost & Publ Hlth, Unit Epidemiol & Med Stat, Verona, Italy.Univ Verona, Dept Diagnost & Publ Hlth, Unit Epidemiol & Med Stat, Verona, Italy.;Sorbonne Univ, INSERM, UMR S 1136, IPLESP,Team EPAR, F-75012 Paris, France. (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:Scientific Reports: NATURE PUBLISHING GROUP10:12045-2322

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