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Incidence trends of...
Incidence trends of airflow obstruction among European adults without asthma : a 20-year cohort study
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- Accordini, Simone (författare)
- Univ Verona, Dept Diagnost & Publ Hlth, Unit Epidemiol & Med Stat, Verona, Italy.
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- Calciano, Lucia (författare)
- Univ Verona, Dept Diagnost & Publ Hlth, Unit Epidemiol & Med Stat, Verona, Italy.
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- Marcon, Alessandro (författare)
- Univ Verona, Dept Diagnost & Publ Hlth, Unit Epidemiol & Med Stat, Verona, Italy.
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- Pesce, Giancarlo (författare)
- Univ Verona, Dept Diagnost & Publ Hlth, Unit Epidemiol & Med Stat, Verona, Italy.;Sorbonne Univ, INSERM, UMR S 1136, IPLESP,Team EPAR, F-75012 Paris, France.
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- Ant, Josep M. (författare)
- Ctr Res Environm Epidemiol CREAL, ISGlobal, Barcelona, Spain.;Hosp del Mar Med Res Inst IMIM, Barcelona, Spain.;CIBER Epidemiol & Salud Publ CIBERESP, Barcelona, Spain.;Univ Pompeu Fabra UPF, Barcelona, Spain.
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- Beckmeyer-Borowko, Anna B. (författare)
- Swiss Trop & Publ Hlth Inst, Dept Epidemiol & Publ Hlth, Basel, Switzerland.;Univ Basel, Basel, Switzerland.
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- Carsin, Anne-Elie (författare)
- Ctr Res Environm Epidemiol CREAL, ISGlobal, Barcelona, Spain.;CIBER Epidemiol & Salud Publ CIBERESP, Barcelona, Spain.;Univ Pompeu Fabra UPF, Barcelona, Spain.
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- Corsico, Angelo G. (författare)
- Univ Pavia, San Matteo Hosp Fdn, IRCCS, Div Resp Dis, Pavia, Italy.
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- Imboden, Medea (författare)
- Swiss Trop & Publ Hlth Inst, Dept Epidemiol & Publ Hlth, Basel, Switzerland.;Univ Basel, Basel, Switzerland.
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- Janson, Christer (författare)
- Uppsala universitet,Lung- allergi- och sömnforskning
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- Keidel, Dirk (författare)
- Swiss Trop & Publ Hlth Inst, Dept Epidemiol & Publ Hlth, Basel, Switzerland.;Univ Basel, Basel, Switzerland.
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- Locatelli, Francesca (författare)
- Univ Verona, Dept Diagnost & Publ Hlth, Unit Epidemiol & Med Stat, Verona, Italy.
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- Svanes, Cecilie (författare)
- Univ Bergen, Dept Global Publ Hlth & Primary Care, Ctr Int Hlth, Bergen, Norway.;Haukeland Hosp, Dept Occupat Med, Bergen, Norway.
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- Burney, Peter G. J. (författare)
- Imperial Coll London, Natl Heart & Lung Inst, Populat Hlth & Occupat Dis, London, England.;Imperial Coll London, MRC PHE Ctr Environm & Hlth, London, England.
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- Jarvis, Deborah (författare)
- Imperial Coll London, Natl Heart & Lung Inst, Populat Hlth & Occupat Dis, London, England.;Imperial Coll London, MRC PHE Ctr Environm & Hlth, London, England.
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- Probst-Hensch, Nicole M. (författare)
- Swiss Trop & Publ Hlth Inst, Dept Epidemiol & Publ Hlth, Basel, Switzerland.;Univ Basel, Basel, Switzerland.
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- Minelli, Cosetta (författare)
- Imperial Coll London, Natl Heart & Lung Inst, Populat Hlth & Occupat Dis, London, England.
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Univ Verona, Dept Diagnost & Publ Hlth, Unit Epidemiol & Med Stat, Verona, Italy Univ Verona, Dept Diagnost & Publ Hlth, Unit Epidemiol & Med Stat, Verona, Italy.;Sorbonne Univ, INSERM, UMR S 1136, IPLESP,Team EPAR, F-75012 Paris, France. (creator_code:org_t)
- 2020-02-26
- 2020
- Engelska.
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Ingår i: Scientific Reports. - : NATURE PUBLISHING GROUP. - 2045-2322. ; 10:1
- Relaterad länk:
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https://doi.org/10.1...
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https://uu.diva-port... (primary) (Raw object)
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https://europepmc.or...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Investigating COPD trends may help healthcare providers to forecast future disease burden. We estimated sex- and smoking-specific incidence trends of pre-bronchodilator airflow obstruction (AO) among adults without asthma from 11 European countries within a 20-year follow-up (ECRHS and SAPALDIA cohorts). We also quantified the extent of misclassification in the definition based on pre-bronchodilator spirometry (using post-bronchodilator measurements from a subsample of subjects) and we used this information to estimate the incidence of post-bronchodilator AO (AO(post-BD)), which is the primary characteristic of COPD. AO incidence was 4.4 (95% CI: 3.5-5.3) male and 3.8 (3.1-4.6) female cases/1,000/year. Among ever smokers (median pack-years: 20, males; 12, females), AO incidence significantly increased with ageing in men only [incidence rate ratio (IRR), 1-year increase: 1.05 (1.03-1.07)]. A strong exposure-response relationship with smoking was found both in males [IRR, 1-pack-year increase: 1.03 (1.02-1.04)] and females [1.03 (1.02-1.05)]. The positive predictive value of AO for AO(post-BD) was 59.1% (52.0-66.2%) in men and 42.6% (35.1-50.1%) in women. AO(post-BD) incidence was 2.6 (1.7-3.4) male and 1.6 (1.0-2.2) female cases/1,000/year. AO incidence was considerable in Europe and the sex-specific ageing-related increase among ever smokers was strongly related to cumulative tobacco exposure. AO(post-BD) incidence is expected to be half of AO incidence.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Lungmedicin och allergi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Respiratory Medicine and Allergy (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Arbetsmedicin och miljömedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Occupational Health and Environmental Health (hsv//eng)
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Accordini, Simon ...
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Calciano, Lucia
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Marcon, Alessand ...
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Pesce, Giancarlo
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Ant, Josep M.
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Beckmeyer-Borowk ...
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visa fler...
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Carsin, Anne-Eli ...
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Corsico, Angelo ...
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Imboden, Medea
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Janson, Christer
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Keidel, Dirk
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Locatelli, Franc ...
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Svanes, Cecilie
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Burney, Peter G. ...
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Jarvis, Deborah
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Probst-Hensch, N ...
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Minelli, Cosetta
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Lungmedicin och ...
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Hälsovetenskap
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och Arbetsmedicin oc ...
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Uppsala universitet