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Genomic epidemiolog...
Genomic epidemiology of Campylobacter jejuni associated with asymptomatic pediatric infection in the Peruvian Amazon
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- Pascoe, Ben (författare)
- Univ Bath, Milner Ctr Evolut, Dept Biol & Biochem, Bath, Avon, England.;Chiang Mai Univ, Fac Associated Med Sci, Chiang Mai, Thailand.
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- Schiaffino, Francesca (författare)
- Johns Hopkins Bloomberg Sch Publ Hlth, Dept Int Hlth, Baltimore, MD USA.;Univ Peruana Cayetano Heredia, Fac Vet Med, Lima, Peru.
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- Murray, Susan (författare)
- Uppsala universitet,Institutionen för medicinsk biokemi och mikrobiologi,Science for Life Laboratory, SciLifeLab,Swansea Univ, Med Sch, Singleton Pk, Swansea, W Glam, Wales.
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- Meric, Guillaume (författare)
- Univ Bath, Milner Ctr Evolut, Dept Biol & Biochem, Bath, Avon, England.;Baker Heart & Diabet Inst, Cambridge Baker Syst Genom Initiat, Melbourne, Vic, Australia.;Monash Univ, Cent Clin Sch, Dept Infect Dis, Melbourne, Vic, Australia.
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- Bayliss, Sion C. (författare)
- Univ Bath, Milner Ctr Evolut, Dept Biol & Biochem, Bath, Avon, England.
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- Hitchings, Matthew D. (författare)
- Swansea Univ, Med Sch, Singleton Pk, Swansea, W Glam, Wales.
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- Mourkas, Evangelos (författare)
- Univ Bath, Milner Ctr Evolut, Dept Biol & Biochem, Bath, Avon, England.
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- Calland, Jessica K. (författare)
- Univ Bath, Milner Ctr Evolut, Dept Biol & Biochem, Bath, Avon, England.
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- Burga, Rosa (författare)
- Naval Med Res Unit 6 NAMRU 6, Bacteriol Dept, Iquitos, Peru.
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- Yori, Pablo Penataro (författare)
- Univ Virginia, Div Infect Dis & Int Hlth, Charlottesville, VA 22901 USA.;Assoc Benefice Prisma, Loreto, Peru.
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- Jolley, Keith A. (författare)
- Univ Oxford, Dept Zool, South Parks Rd, Oxford, England.
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- Cooper, Kerry K. (författare)
- Univ Arizona, Sch Anim & Comparat Biomed Sci, Tucson, AZ USA.
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- Parker, Craig T. (författare)
- ARS, Produce Safety & Microbiol Res Unit, USDA, Albany, CA USA.
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- Olortegui, Maribel Paredes (författare)
- Assoc Benefice Prisma, Loreto, Peru.
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- Kosek, Margaret N. (författare)
- Univ Virginia, Div Infect Dis & Int Hlth, Charlottesville, VA 22901 USA.;Assoc Benefice Prisma, Loreto, Peru.
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- Sheppard, Samuel K. (författare)
- Univ Bath, Milner Ctr Evolut, Dept Biol & Biochem, Bath, Avon, England.;Chiang Mai Univ, Fac Associated Med Sci, Chiang Mai, Thailand.;Univ Oxford, Dept Zool, South Parks Rd, Oxford, England.
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Univ Bath, Milner Ctr Evolut, Dept Biol & Biochem, Bath, Avon, England;Chiang Mai Univ, Fac Associated Med Sci, Chiang Mai, Thailand. Johns Hopkins Bloomberg Sch Publ Hlth, Dept Int Hlth, Baltimore, MD USA.;Univ Peruana Cayetano Heredia, Fac Vet Med, Lima, Peru. (creator_code:org_t)
- 2020-08-10
- 2020
- Engelska.
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Ingår i: PLoS Neglected Tropical Diseases. - : PUBLIC LIBRARY SCIENCE. - 1935-2727 .- 1935-2735. ; 14:8
- Relaterad länk:
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https://doi.org/10.1...
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https://uu.diva-port... (primary) (Raw object)
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https://journals.plo...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
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- Author summary Campylobacteris the leading bacterial cause of gastroenteritis worldwide and despite high incidence in low- and middle-income countries (LMICs), where infection can be fatal, culture based isolation is rare and the genotypes responsible for disease have not broadly been identified. The epidemiology of disease is different to that in high income countries, where sporadic infection associated with contaminated food consumption typically leads to acute gastroenteritis. In some LMICs infection is endemic among children and common asymptomatic carriage is associated with malnutrition, attenuated growth in early childhood, and poor cognitive and physical development. Here, we sequenced the genomes of isolates sampled from children in the Peruvian Amazon to investigate genotypes associated with varying disease severity and the source of infection. Among the common globally circulating genotypes and local genotypes rarely seen before, no single lineage was responsible for symptomatic or asymptomatic infection-suggesting an important role for host factors. However, consistent with other countries, poultry-associated strains were a likely major source of infection. This genomic surveillance approach, that integrates microbial ecology with population based studies in humans and animals, has considerable potential for describing cryptic epidemiology in LMICs and will inform work to improve infant health worldwide. Campylobacteris the leading bacterial cause of gastroenteritis worldwide and its incidence is especially high in low- and middle-income countries (LMIC). Disease epidemiology in LMICs is different compared to high income countries like the USA or in Europe. Children in LMICs commonly have repeated and chronic infections even in the absence of symptoms, which can lead to deficits in early childhood development. In this study, we sequenced and characterizedC.jejuni(n = 62) from a longitudinal cohort study of children under the age of 5 with and without diarrheal symptoms, and contextualized them within a globalC.jejunigenome collection. Epidemiological differences in disease presentation were reflected in the genomes, specifically by the absence of some of the most common global disease-causing lineages. As in many other countries, poultry-associated strains were likely a major source of human infection but almost half of local disease cases (15 of 31) were attributable to genotypes that are rare outside of Peru. Asymptomatic infection was not limited to a single (or few) human adapted lineages but resulted from phylogenetically divergent strains suggesting an important role for host factors in the cryptic epidemiology of campylobacteriosis in LMICs.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Infektionsmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Infectious Medicine (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Public Health, Global Health, Social Medicine and Epidemiology (hsv//eng)
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- Av författaren/redakt...
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Pascoe, Ben
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Schiaffino, Fran ...
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Murray, Susan
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Meric, Guillaume
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Bayliss, Sion C.
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Hitchings, Matth ...
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visa fler...
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Mourkas, Evangel ...
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Calland, Jessica ...
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Burga, Rosa
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Yori, Pablo Pena ...
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Jolley, Keith A.
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Cooper, Kerry K.
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Parker, Craig T.
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Olortegui, Marib ...
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Kosek, Margaret ...
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Sheppard, Samuel ...
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Infektionsmedici ...
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Hälsovetenskap
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och Folkhälsovetensk ...
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PLoS Neglected T ...
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Uppsala universitet