SwePub
Sök i LIBRIS databas

  Extended search

WFRF:(Hoffmann Ulrich)
 

Search: WFRF:(Hoffmann Ulrich) > Tumor immune escape...

  • Pivarcsi, Andor (author)

Tumor immune escape by the loss of homeostatic chemokine expression.

  • Article/chapterEnglish2007

Publisher, publication year, extent ...

  • 2007-11-27
  • Proceedings of the National Academy of Sciences,2007
  • printrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:uu-421700
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-421700URI
  • https://doi.org/10.1073/pnas.0705673104DOI

Supplementary language notes

  • Language:English
  • Summary in:English &language:-1_t

Part of subdatabase

Classification

  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • The novel keratinocyte-specific chemokine CCL27 plays a critical role in the organization of skin-associated immune responses by regulating T cell homing under homeostatic and inflammatory conditions. Here we demonstrate that human keratinocyte-derived skin tumors may evade T cell-mediated antitumor immune responses by down-regulating the expression of CCL27 through the activation of epidermal growth factor receptor (EGFR)-Ras-MAPK-signaling pathways. Compared with healthy skin, CCL27 mRNA and protein expression was progressively lost in transformed keratinocytes of actinic keratoses and basal and squamous cell carcinomas. In vivo, precancerous skin lesions as well as cutaneous carcinomas showed significantly elevated levels of phosphorylated ERK compared with normal skin, suggesting the activation of EGFR-Ras signaling pathways in keratinocyte-derived malignancies. In vitro, exogenous stimulation of the EGFR-Ras signaling pathway through EGF or transfection of the dominant-active form of the Ras oncogene (H-RasV12) suppressed whereas an EGFR tyrosine kinase inhibitor increased CCL27 mRNA and protein production in keratinocytes. In mice, neutralization of CCL27 led to decreased leukocyte recruitment to cutaneous tumor sites and significantly enhanced primary tumor growth. Collectively, our data identify a mechanism of skin tumors to evade host antitumor immune responses.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Müller, Anja (author)
  • Hippe, Andreas (author)
  • Rieker, Juliane (author)
  • van Lierop, Anke (author)
  • Steinhoff, Martin (author)
  • Seeliger, Stephan (author)
  • Kubitza, Robert (author)
  • Pippirs, Ulrich (author)
  • Meller, Stephan (author)
  • Gerber, Peter A (author)
  • Liersch, Ruediger (author)
  • Buenemann, Erich (author)
  • Sonkoly, Eniko (author)
  • Wiesner, Ulrike (author)
  • Hoffmann, Thomas K (author)
  • Schneider, Leonid (author)
  • Piekorz, Roland (author)
  • Enderlein, Elaine (author)
  • Reifenberger, Julia (author)
  • Rohr, Ulrich-Peter (author)
  • Haas, Rainer (author)
  • Boukamp, Petra (author)
  • Haase, Ingo (author)
  • Nürnberg, Bernd (author)
  • Ruzicka, Thomas (author)
  • Zlotnik, Albert (author)
  • Homey, Bernhard (author)

Related titles

  • In:Proceedings of the National Academy of Sciences of the United States of America: Proceedings of the National Academy of Sciences104:48, s. 19055-600027-84241091-6490

Internet link

Find in a library

To the university's database

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Close

Copy and save the link in order to return to this view