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  • Sonkoly, EniköKarolinska Institutet (author)

MicroRNAs : novel regulators involved in the pathogenesis of psoriasis?

  • Article/chapterEnglish2007

Publisher, publication year, extent ...

  • 2007-07-11
  • Public Library of Science (PLoS),2007
  • printrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:uu-421702
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-421702URI
  • https://doi.org/10.1371/journal.pone.0000610DOI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:119843599URI

Supplementary language notes

  • Language:English
  • Summary in:English &language:-1_t

Part of subdatabase

Classification

  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • MicroRNAs are a recently discovered class of posttranscriptional regulators of gene expression with critical functions in health and disease. Psoriasis is the most prevalent chronic inflammatory skin disease in adults, with a substantial negative impact on the patients' quality of life. Here we show for the first time that psoriasis-affected skin has a specific microRNA expression profile when compared with healthy human skin or with another chronic inflammatory skin disease, atopic eczema. Among the psoriasis-specific microRNAs, we identified leukocyte-derived microRNAs and one keratinocyte-derived microRNA, miR-203. In a panel of 21 different human organs and tissues, miR-203 showed a highly skin-specific expression profile. Among the cellular constituents of the skin, it was exclusively expressed by keratinocytes. The up-regulation of miR-203 in psoriatic plaques was concurrent with the down-regulation of an evolutionary conserved target of miR-203, suppressor of cytokine signaling 3 (SOCS-3), which is involved in inflammatory responses and keratinocyte functions. Our results suggest that microRNA deregulation is involved in the pathogenesis of psoriasis and contributes to the dysfunction of the cross talk between resident and infiltrating cells. Taken together, a new layer of regulatory mechanisms is involved in the pathogenesis of chronic inflammatory skin diseases.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Wei, Tianling (author)
  • Janson, Peter C J (author)
  • Sääf, Annika (author)
  • Lundeberg, Lena (author)
  • Tengvall-Linder, MariaKarolinska Institutet (author)
  • Norstedt, GunnarKarolinska Institutet (author)
  • Alenius, Harri (author)
  • Homey, Bernhard (author)
  • Scheynius, AnnikaKarolinska Institutet (author)
  • Ståhle, MonaKarolinska Institutet (author)
  • Pivarcsi, AndorKarolinska Institutet(Swepub:uu)andpi932 (author)
  • Karolinska Institutet (creator_code:org_t)

Related titles

  • In:PLOS ONE: Public Library of Science (PLoS)2:71932-6203

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