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  • Sonkoly, Eniko (author)

IL-31 : a new link between T cells and pruritus in atopic skin inflammation.

  • Article/chapterEnglish2006

Publisher, publication year, extent ...

  • Elsevier BV,2006
  • printrdacarrier

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  • LIBRIS-ID:oai:DiVA.org:uu-421707
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-421707URI
  • https://doi.org/10.1016/j.jaci.2005.10.033DOI

Supplementary language notes

  • Language:English
  • Summary in:English &language:-1_t

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  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • BACKGROUND: IL-31 is a novel T-cell-derived cytokine that induces severe pruritus and dermatitis in transgenic mice, and signals through a heterodimeric receptor composed of IL-31 receptor A and oncostatin M receptor.OBJECTIVE: To investigate the role of human IL-31 in pruritic and nonpruritic inflammatory skin diseases.METHODS: The expression of IL-31 was analyzed by quantitative real-time PCR in skin samples of healthy individuals and patients with chronic inflammatory skin diseases. Moreover, IL-31 expression was analyzed in nonlesional skin of atopic dermatitis patients after allergen or superantigen exposure, as well as in stimulated leukocytes. The tissue distribution of the IL-31 receptor heterodimer was investigated by DNA microarray analysis.RESULTS: IL-31 was significantly overexpressed in pruritic atopic compared with nonpruritic psoriatic skin inflammation. Highest IL-31 levels were detected in prurigo nodularis, one of the most pruritic forms of chronic skin inflammation. In vivo, staphylococcal superantigen rapidly induced IL-31 expression in atopic individuals. In vitro, staphylococcal enterotoxin B but not viruses or T(H)1 and T(H)2 cytokines induced IL-31 in leukocytes. In patients with atopic dermatitis, activated leukocytes expressed significantly higher IL-31 levels compared with control subjects. IL-31 receptor A showed most abundant expression in dorsal root ganglia representing the site where the cell bodies of cutaneous sensory neurons reside.CONCLUSION: Our findings provide a new link among staphylococcal colonization, subsequent T-cell recruitment/activation, and pruritus induction in patients with atopic dermatitis. Taken together, these findings show that IL-31 may represent a novel target for antipruritic drug development.

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  • Muller, Anja (author)
  • Lauerma, Antti I (author)
  • Pivarcsi, Andor (author)
  • Soto, Hortensia (author)
  • Kemeny, Lajos (author)
  • Alenius, Harri (author)
  • Dieu-Nosjean, Marie-Caroline (author)
  • Meller, Stephan (author)
  • Rieker, Juliane (author)
  • Steinhoff, Martin (author)
  • Hoffmann, Thomas K (author)
  • Ruzicka, Thomas (author)
  • Zlotnik, Albert (author)
  • Homey, Bernhard (author)

Related titles

  • In:Journal of Allergy and Clinical Immunology: Elsevier BV117:2, s. 411-70091-67491097-6825

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