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  • Papp, ZoltanUniv Debrecen, Fac Med, Dept Cardiol, Debrecen, Hungary. (author)

Levosimendan Efficacy and Safety : 20 Years of SIMDAX in Clinical Use

  • Article/chapterEnglish2020

Publisher, publication year, extent ...

  • Ovid Technologies (Wolters Kluwer Health),2020
  • electronicrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:uu-421865
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-421865URI
  • https://doi.org/10.1097/FJC.0000000000000859DOI

Supplementary language notes

  • Language:English
  • Summary in:English

Part of subdatabase

Classification

  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Levosimendan was first approved for clinical use in 2000, when authorization was granted by Swedish regulatory authorities for the hemodynamic stabilization of patients with acutely decompensated chronic heart failure (HF). In the ensuing 20 years, this distinctive inodilator, which enhances cardiac contractility through calcium sensitization and promotes vasodilatation through the opening of adenosine triphosphate-dependent potassium channels on vascular smooth muscle cells, has been approved in more than 60 jurisdictions, including most of the countries of the European Union and Latin America. Areas of clinical application have expanded considerably and now include cardiogenic shock, takotsubo cardiomyopathy, advanced HF, right ventricular failure, pulmonary hypertension, cardiac surgery, critical care, and emergency medicine. Levosimendan is currently in active clinical evaluation in the United States. Levosimendan in IV formulation is being used as a research tool in the exploration of a wide range of cardiac and noncardiac disease states. A levosimendan oral form is at present under evaluation in the management of amyotrophic lateral sclerosis. To mark the 20 years since the advent of levosimendan in clinical use, 51 experts from 23 European countries (Austria, Belgium, Croatia, Cyprus, Czech Republic, Estonia, Finland, France, Germany, Greece, Hungary, Italy, the Netherlands, Norway, Poland, Portugal, Russia, Slovenia, Spain, Sweden, Switzerland, the United Kingdom, and Ukraine) contributed to this essay, which evaluates one of the relatively few drugs to have been successfully introduced into the acute HF arena in recent times and charts a possible development trajectory for the next 20 years.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Agostoni, PiergiuseppeIRCCS, Dept Clin Sci & Community Hlth, Ctr Cardiol Monzino, Milan, Italy. (author)
  • Alvarez, JulianUniv Santiago de Compostela, Sch Med, Dept Surg, Santiago De Compostela, Spain. (author)
  • Bettex, DominiqueUniv Hosp Zurich, Inst Anaesthesiol, Zurich, Switzerland. (author)
  • Bouchez, StefanUniv Hosp, Dept Anaesthesiol, Ghent, Belgium. (author)
  • Brito, DulceUniv Lisbon, Ctr Hosp Univ Lisboa Norte, Fac Med, Cardiol Dept,CCUI, Lisbon, Portugal. (author)
  • Cerny, VladimirUniv JE Purkyne, Masaryk Hosp, Dept Anaesthesiol Perioperat Med & Intens Care, Usti Nad Labem, Czech Republic. (author)
  • Comin-Colet, JosepHosp Univ Bellvitge, Heart Dis Inst, Barcelona, Spain. (author)
  • Crespo-Leiro, Marisa G.Univ Coruna UDC, Complexo Hosp Univ A Coruna CHUAC, Inst Invest Biomed A Coruna Inib, CIBERCV, La Coruna, Spain. (author)
  • Delgado, Juan F.Univ Hosp 12 Octubre, Heart Failure & Transplant Program, Cardiol Dept, Madrid, Spain. (author)
  • Edes, IstvanUniv Debrecen, Fac Med, Dept Cardiol, Debrecen, Hungary. (author)
  • Eremenko, Alexander A.Sechenov Univ, Petrovskii Natl Res Ctr Surg, Dept Cardiac Intens Care, Moscow, Russia. (author)
  • Farmakis, DimitriosUniv Cyprus, Med Sch, Dept Cardiol, Nicosia, Cyprus. (author)
  • Fedele, FrancescoSapienza Univ Rome, Dept Cardiovasc Resp Nephrol Anaesthesiol & Geria, Rome, Italy. (author)
  • Fonseca, CandidaSao Francisco Xavier Hosp, CHLO, Heart Failure Clin, Lisbon, Portugal. (author)
  • Fruhwald, SonjaMed Univ Graz, Dept Anaesthesiol & Intens Care Med, Div Anaesthesiol Cardiovasc Surg & Intens Care Me, Graz, Austria. (author)
  • Girardis, MassimoPoliclin Modena, Struttura Complessa Anestesia 1, Modena, Italy. (author)
  • Guarracino, FabioAzienda Osped Univ Pisana, Dipartimento Anestesia & Terapie Intens, Pisa, Italy. (author)
  • Harjola, Veli-PekkaUniv Helsinki, Meilahti Cent Univ Hosp, Emergency Med, Helsinki, Finland. (author)
  • Heringlake, MatthiasUniv Lubeck, Dept Anaesthesiol & Intens Care Med, Lubeck, Germany. (author)
  • Herpain, AntoineHop Erasme, Dept Intens Care, Brussels, Belgium. (author)
  • Heunks, Leo M. A.Amsterdam UMC, Dept Intens Care Med, Amsterdam, Netherlands. (author)
  • Husebye, TryggveOslo Univ Hosp Ullevaal, Dept Cardiol, Oslo, Norway. (author)
  • Ivancan, VisnjaUniv Hosp Ctr, Dept Anaesthesiol Reanimatol & Intens Care, Zagreb, Croatia. (author)
  • Karason, KristjanSahlgrens Univ Hosp, Dept Cardiol, Gothenburg, Sweden.;Sahlgrens Univ Hosp, Dept Transplantat, Gothenburg, Sweden. (author)
  • Kaul, SundeepNatl Hlth Serv, Intens Care Unit, Leeds, W Yorkshire, England. (author)
  • Kivikko, MattiOrion Pharma, R&D, Global Med Affairs, Espoo, Finland. (author)
  • Kubica, JanekNicolaus Copernicus Univ, Dept Cardiol & Internal Med, Torun, Poland. (author)
  • Masip, JosepUniv Barcelona, Intens Care Dept, Consorci Sanitari Integral, Barcelona, Spain. (author)
  • Matskeplishvili, SimonLomonosov Moscow State Univ, Med Ctr, Moscow, Russia. (author)
  • Mebazaa, AlexandreSt Louis & Lariboisiere Univ Hosp, AP HP, Dept Anaesthesiol & Crit Care Med, Paris, France. (author)
  • Nieminen, Markku S.Sydantutkimussaatio, Helsinki, Finland. (author)
  • Oliva, FabrizioOsped Niguarda Ca Granda, Dept Cardiol, Milan, Italy. (author)
  • Papp, Julius G.Univ Szeged, Hungarian Acad Sci, MTA SZTE Res Grp Cardiovasc Pharmacol, Szeged, Hungary. (author)
  • Parissis, JohnNatl & Kapodistrian Univ Athens, Attikon Univ Hosp, Dept Cardiol 2, Athens, Greece. (author)
  • Parkhomenko, AlexanderNatl Sci Ctr MD Strazhesko Inst Cardiol, Emergency Cardiol Dept, Kiev, Ukraine. (author)
  • Poder, PenttiNorth Estonia Med Ctr, Dept Cardiol, Tallinn, Estonia. (author)
  • Poelzl, GerhardMed Univ Innsbruck, Dept Internal Med Cardiol & Angiol 3, Innsbruck, Austria. (author)
  • Reinecke, AlexanderUniv Klinikum Schleswig Holstein, Kardiol, Klin Innere Med 3, Kiel, Germany. (author)
  • Ricksten, Sven-ErikSahlgrens Univ Hosp, Dept Anaesthesiol & Intens Care, Gothenburg, Sweden. (author)
  • Riha, HynekInst Clin & Expt Med, Dept Anaesthesiol & Intens Care Med Cardiothorac, Prague, Czech Republic. (author)
  • Rudiger, AlainSpittal Limmattal, Dept Med, Schlieren, Switzerland. (author)
  • Sarapohja, ToniOrion Pharma, Stat Serv, R&D, Espoo, Finland. (author)
  • Schwinger, Robert H. G.Teaching Hosp Univ Regensburg, Klinikum Weiden, Med Klin 2, Weiden, Germany. (author)
  • Toller, WolfgangMed Univ Graz, Dept Anaesthesiol & Intens Care Med, Graz, Austria. (author)
  • Tritapepe, LuigiSan Camillo Forlanini Hosp, Anaesthesia & Intens Care Div, Rome, Italy. (author)
  • Tschoepe, CarstenCharite Univ Med Berlin, Dept Cardiol, Campus Virchow Klinikum, Berlin, Germany. (author)
  • Wikström, GerhardUppsala universitet,Kardiologi(Swepub:uu)gewik021 (author)
  • von Lewinski, DirkMed Univ Graz, Dept Cardiol, Myokardiale Energet & Metabolismus Res Unit, Graz, Austria. (author)
  • Vrtovec, BojanUniv Clin Ctr, Adv Heart Failure & Transplantat Ctr, Dept Cardiol, Ljubljana, Slovenia. (author)
  • Pollesello, PieroOrion Pharma, Crit Care Proprietary Prod, POB 65, FIN-02101 Espoo, Finland. (author)
  • Univ Debrecen, Fac Med, Dept Cardiol, Debrecen, Hungary.IRCCS, Dept Clin Sci & Community Hlth, Ctr Cardiol Monzino, Milan, Italy. (creator_code:org_t)

Related titles

  • In:Journal of Cardiovascular Pharmacology: Ovid Technologies (Wolters Kluwer Health)76:1, s. 4-220160-24461533-4023

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