Chocolate consumption and risk of stroke A prospective cohort of men and meta-analysis

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Larsson, Susanna C.Karolinska Institutet (author)

Chocolate consumption and risk of stroke A prospective cohort of men and meta-analysis

Article/chapterEnglish2012

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LIPPINCOTT WILLIAMS & WILKINS,2012
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LIBRIS-ID:oai:DiVA.org:uu-422064
https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-422064URI
https://doi.org/10.1212/WNL.0b013e31826aacfaDOI
http://kipublications.ki.se/Default.aspx?queryparsed=id:125343110URI

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Language:English
Summary in:English

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Objective: To investigate the association between chocolate consumption and risk of stroke in men and conduct a meta-analysis to summarize available evidence from prospective studies of chocolate consumption and stroke. Methods: We prospectively followed 37,103 men in the Cohort of Swedish Men. Chocolate consumption was assessed at baseline using a food-frequency questionnaire. Cases of first stroke were ascertained from the Swedish Hospital Discharge Registry. For the meta-analysis, pertinent studies were identified by searching the PubMed and EMBASE databases through January 13, 2012. Study-specific results were combined using a random-effects model. Results: During 10.2 years of follow-up, we ascertained 1,995 incident stroke cases, including 1,511 cerebral infarctions, 321 hemorrhagic strokes, and 163 unspecified strokes. High chocolate consumption was associated with a lower risk of stroke. The multivariable relative risk of stroke comparing the highest quartile of chocolate consumption (median 62.9 g/week) with the lowest quartile (median 0 g/week) was 0.83 (95% CI 0.70-0.99). The association did not differ by stroke subtypes. In a meta-analysis of 5 studies, with a total of 4,260 stroke cases, the overall relative risk of stroke for the highest vs lowest category of chocolate consumption was 0.81 (95% CI 0.73-0.90), without heterogeneity among studies (p = 0.47). Conclusion: These findings suggest that moderate chocolate consumption may lower the risk of stroke. Neurology (R) 2012;79:1223-1229

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Virtamo, JarmoNatl Inst Hlth & Welf, Dept Chron Dis Prevent, Helsinki, Finland. (author)
Wolk, AlicjaKarolinska Institutet (author)
Karolinska InstitutetNatl Inst Hlth & Welf, Dept Chron Dis Prevent, Helsinki, Finland. (creator_code:org_t)

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In:Neurology: LIPPINCOTT WILLIAMS & WILKINS79:12, s. 1223-12290028-38781526-632X

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MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Neurology

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Cardiac and Card ...

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