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  • de Gonzalez, Amy BerringtonNCI, Div Canc Epidemiol & Genet, NIH, Bethesda, MD 20892 USA. (author)

Body-Mass Index and Mortality among 1.46 Million White Adults.

  • Article/chapterEnglish2010

Publisher, publication year, extent ...

  • MASSACHUSETTS MEDICAL SOC,2010
  • printrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:uu-422096
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-422096URI
  • https://doi.org/10.1056/NEJMoa1000367DOI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:121623389URI

Supplementary language notes

  • Language:English
  • Summary in:English

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  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Background: A high body-mass index (BMI, the weight in kilograms divided by the square of the height in meters) is associated with increased mortality from cardiovascular disease and certain cancers, but the precise relationship between BMI and all-cause mortality remains uncertain. Methods: We used Cox regression to estimate hazard ratios and 95% confidence intervals for an association between BMI and all-cause mortality, adjusting for age, study, physical activity, alcohol consumption, education, and marital status in pooled data from 19 prospective studies encompassing 1.46 million white adults, 19 to 84 years of age (median, 58). Results: The median baseline BMI was 26.2. During a median follow-up period of 10 years (range, 5 to 28), 160,087 deaths were identified. Among healthy participants who never smoked, there was a J-shaped relationship between BMI and all-cause mortality. With a BMI of 22.5 to 24.9 as the reference category, hazard ratios among women were 1.47 (95 percent confidence interval [CI], 1.33 to 1.62) for a BMI of 15.0 to 18.4; 1.14 (95% CI, 1.07 to 1.22) for a BMI of 18.5 to 19.9; 1.00 (95% CI, 0.96 to 1.04) for a BMI of 20.0 to 22.4; 1.13 (95% CI, 1.09 to 1.17) for a BMI of 25.0 to 29.9; 1.44 (95% CI, 1.38 to 1.50) for a BMI of 30.0 to 34.9; 1.88 (95% CI, 1.77 to 2.00) for a BMI of 35.0 to 39.9; and 2.51 (95% CI, 2.30 to 2.73) for a BMI of 40.0 to 49.9. In general, the hazard ratios for the men were similar. Hazard ratios for a BMI below 20.0 were attenuated with longer-term follow-up. Conclusions: In white adults, overweight and obesity (and possibly underweight) are associated with increased all-cause mortality. All-cause mortality is generally lowest with a BMI of 20.0 to 24.9. N Engl J Med 2010;363:2211-9.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Hartge, Patricia (author)
  • Cerhan, James R.Mayo Clin, Coll Med, Div Epidemiol, Rochester, MN USA. (author)
  • Flint, Alan J.Harvard Univ, Sch Publ Hlth, Dept Nutr, Boston, MA 02115 USA. (author)
  • Hannan, LindsayAmer Canc Soc, Dept Epidemiol & Surveillance Res, Atlanta, GA 30329 USA. (author)
  • MacInnis, Robert J.Univ Melbourne, Ctr Mol Environm Genet & Analyt Epidemiol, Melbourne, Vic, Australia.;Univ Cambridge, Canc Res UK Genet Epidemiol Unit, Cambridge, England. (author)
  • Moore, Steven C. (author)
  • Tobias, Geoffrey S. (author)
  • Anton-Culver, HodaUniv Calif Irvine, Sch Med, Dept Epidemiol, Irvine, CA 92717 USA. (author)
  • Freeman, Laura Beane (author)
  • Beeson, W. LawrenceLoma Linda Univ, Sch Publ Hlth, Loma Linda, CA 92350 USA. (author)
  • Clipp, Sandra L.Johns Hopkins Bloomberg Sch Publ Hlth, Dept Epidemiol, Baltimore, MD USA. (author)
  • English, Dallas R.Univ Melbourne, Ctr Mol Environm Genet & Analyt Epidemiol, Melbourne, Vic, Australia. (author)
  • Folsom, Aaron R.Univ Minnesota, Sch Publ Hlth, Minneapolis, MN USA. (author)
  • Freedman, D. Michal (author)
  • Giles, GrahamCanc Council Victoria, Canc Epidemiol Ctr, Melbourne, Vic, Australia. (author)
  • Hakansson, NiclasKarolinska Institutet (author)
  • Henderson, Katherine D.City Hope Natl Med Ctr, Dept Populat Sci, Duarte, CA 91010 USA. (author)
  • Hoffman-Bolton, JudithJohns Hopkins Bloomberg Sch Publ Hlth, Dept Epidemiol, Baltimore, MD USA. (author)
  • Hoppin, Jane A.Natl Inst Environm Hlth Sci, Epidemiol Branch, Res Triangle Pk, NC USA. (author)
  • Koenig, Karen L.NYU, Sch Med, Dept Environm Med, New York, NY USA. (author)
  • Lee, I-MinHarvard Univ, Sch Med, Boston, MA USA. (author)
  • Linet, Martha S. (author)
  • Park, Yikyung (author)
  • Pocobelli, GaiaUniv Washington, Sch Publ Hlth, Dept Epidemiol, Seattle, WA 98195 USA.;Fred Hutchinson Canc Res Ctr, Canc Prevent Program, Seattle, WA 98104 USA. (author)
  • Schatzkin, Arthur (author)
  • Sesso, Howard D.Brigham & Womens Hosp, Div Prevent Med, Boston, MA 02115 USA.;Brigham & Womens Hosp, Div Aging, Boston, MA 02115 USA. (author)
  • Weiderpass, ElisabeteKarolinska Institutet (author)
  • Willcox, Bradley J.Pacific Hlth Res Inst, Honolulu, HI USA.;Queens Med Ctr, Honolulu, HI USA. (author)
  • Wolk, AlicjaKarolinska Institutet (author)
  • Zeleniuch-Jacquotte, AnneNYU, Sch Med, Dept Environm Med, New York, NY USA. (author)
  • Willett, Walter C.Harvard Univ, Sch Publ Hlth, Dept Nutr, Boston, MA 02115 USA. (author)
  • Thun, Michael J.Amer Canc Soc, Dept Epidemiol & Surveillance Res, Atlanta, GA 30329 USA. (author)
  • NCI, Div Canc Epidemiol & Genet, NIH, Bethesda, MD 20892 USA.Mayo Clin, Coll Med, Div Epidemiol, Rochester, MN USA. (creator_code:org_t)

Related titles

  • In:New England Journal of Medicine: MASSACHUSETTS MEDICAL SOC363:23, s. 2211-22190028-47931533-4406

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