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Folate Intake and R...
Folate Intake and Risk of Pancreatic Cancer : Pooled Analysis of Prospective Cohort Studies
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- Bao, Ying (författare)
- Brigham & Womens Hosp, Dept Med, Channing Lab, Boston, MA USA.;Harvard Univ, Sch Med, Boston, MA 02115 USA.
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- Michaud, Dominique S. (författare)
- Brown Univ, Dept Community Hlth, Providence, RI 02912 USA.
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- Spiegelman, Donna (författare)
- Harvard Univ, Sch Publ Hlth, Dept Biostat, Boston, MA 02115 USA.;Harvard Univ, Sch Publ Hlth, Dept Epidemiol, Boston, MA 02115 USA.
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- Albanes, Demetrius (författare)
- NCI, Div Canc Epidemiol & Genet, Bethesda, MD 20892 USA.
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- Anderson, Kristin E. (författare)
- Univ Minnesota, Sch Publ Hlth, Div Epidemiol & Community Hlth, Minneapolis, MN USA.;Univ Minnesota, Mason Canc Ctr, Minneapolis, MN USA.
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- Bernstein, Leslie (författare)
- City Hope Natl Med Ctr, Beckman Res Inst, Dept Populat Sci, Duarte, CA 91010 USA.
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- van den Brandt, Piet A. (författare)
- Maastricht Univ, Sch Oncol & Dev Biol, Dept Epidemiol, GROW, Maastricht, Netherlands.
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- English, Dallas R. (författare)
- Canc Council Victoria, Canc Epidemiol Ctr, Melbourne, Vic, Australia.
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- Freudenheim, Jo L. (författare)
- SUNY Buffalo, Dept Social & Prevent Med, Buffalo, NY 14260 USA.
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- Fuchs, Charles S. (författare)
- Dana Farber Canc Inst, Dept Adult Oncol, Boston, MA 02115 USA.
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- Giles, Graham G. (författare)
- Canc Council Victoria, Canc Epidemiol Ctr, Melbourne, Vic, Australia.
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- Giovannucci, Edward (författare)
- Brigham & Womens Hosp, Dept Med, Channing Lab, Boston, MA USA.;Harvard Univ, Sch Med, Boston, MA 02115 USA.;Harvard Univ, Sch Publ Hlth, Dept Epidemiol, Boston, MA 02115 USA.;Harvard Univ, Sch Publ Hlth, Dept Nutr, Boston, MA 02115 USA.
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- Goldbohm, R. Alexandra (författare)
- TNO Qual Life, Dept Prevent & Hlth, Leiden, Netherlands.
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- Hakansson, Niclas (författare)
- Karolinska Institutet
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- Horn-Ross, Pamela L. (författare)
- Canc Prevent Inst Calif, Fremont, CA USA.
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- Jacobs, Eric J. (författare)
- Amer Canc Soc, Epidemiol Res Program, Atlanta, GA 30329 USA.
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- Kitahara, Cari M. (författare)
- NCI, Div Canc Epidemiol & Genet, Bethesda, MD 20892 USA.
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- Marshall, James R. (författare)
- Roswell Pk Canc Inst, Dept Canc Prevent & Populat Sci, Buffalo, NY 14263 USA.
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- Miller, Anthony B. (författare)
- Univ Toronto, Div Epidemiol, Dalla Lana Sch Publ Hlth, Toronto, ON, Canada.
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- Robien, Kim (författare)
- Univ Minnesota, Sch Publ Hlth, Div Epidemiol & Community Hlth, Minneapolis, MN USA.;Univ Minnesota, Mason Canc Ctr, Minneapolis, MN USA.
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- Rohan, Thomas E. (författare)
- Albert Einstein Coll Med, Dept Epidemiol & Populat Hlth, Bronx, NY 10467 USA.
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- Schatzkin, Arthur (författare)
- NCI, Div Canc Epidemiol & Genet, Bethesda, MD 20892 USA.
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- Stevens, Victoria L. (författare)
- Amer Canc Soc, Epidemiol Res Program, Atlanta, GA 30329 USA.
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- Stolzenberg-Solomon, Rachael Z. (författare)
- NCI, Div Canc Epidemiol & Genet, Bethesda, MD 20892 USA.
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- Virtamo, Jarmo (författare)
- Natl Inst Hlth & Welf, Dept Chron Dis Prevent, Helsinki, Finland.
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- Wolk, Alicja (författare)
- Karolinska Institutet
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- Ziegler, Regina G. (författare)
- NCI, Div Canc Epidemiol & Genet, Bethesda, MD 20892 USA.
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- Smith-Warner, Stephanie A. (författare)
- Harvard Univ, Sch Publ Hlth, Dept Epidemiol, Boston, MA 02115 USA.;Harvard Univ, Sch Publ Hlth, Dept Nutr, Boston, MA 02115 USA.
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Brigham & Womens Hosp, Dept Med, Channing Lab, Boston, MA USA;Harvard Univ, Sch Med, Boston, MA 02115 USA. Brown Univ, Dept Community Hlth, Providence, RI 02912 USA. (creator_code:org_t)
- 2011-10-27
- 2011
- Engelska.
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Ingår i: Journal of the National Cancer Institute. - : OXFORD UNIV PRESS INC. - 0027-8874 .- 1460-2105. ; 103:24, s. 1840-1850
- Relaterad länk:
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https://academic.oup...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Background Epidemiological studies evaluating the association between folate intake and risk of pancreatic cancer have produced inconsistent results. The statistical power to examine this association has been limited in previous studies partly because of small sample size and limited range of folate intake in some studies. Methods We analyzed primary data from 14 prospective cohort studies that included 319 716 men and 542 948 women to assess the association between folate intake and risk of pancreatic cancer. Folate intake was assessed through a validated food-frequency questionnaire at baseline in each study. Study-specific relative risks (RRs) and 95% confidence intervals (CIs) were estimated using Cox proportional hazards models and then pooled using a random effects model. All statistical tests were two-sided. Results During 7-20 years of follow-up across studies, 2195 pancreatic cancers were identified. No association was observed between folate intake and risk of pancreatic cancer in men and women (highest vs lowest quintile: dietary folate intake, pooled multivariable RR = 1.06, 95% CI = 0.90 to 1.25, P-trend = .47; total folate intake [dietary folate and supplemental folic acid], pooled multivariable RR = 0.96, 95% CI = 0.80 to 1.16, P-trend = .90). No between-study heterogeneity was observed (for dietary folate, P-heterogeneity = .15; for total folate, P-heterogeneity = .22). Conclusion Folate intake was not associated with overall risk of pancreatic cancer in this large pooled analysis.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
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Bao, Ying
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Michaud, Dominiq ...
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Spiegelman, Donn ...
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Albanes, Demetri ...
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Anderson, Kristi ...
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Bernstein, Lesli ...
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visa fler...
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van den Brandt, ...
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English, Dallas ...
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Freudenheim, Jo ...
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Fuchs, Charles S ...
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Giles, Graham G.
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Giovannucci, Edw ...
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Goldbohm, R. Ale ...
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Hakansson, Nicla ...
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Horn-Ross, Pamel ...
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Jacobs, Eric J.
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Kitahara, Cari M ...
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Marshall, James ...
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Miller, Anthony ...
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Robien, Kim
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Rohan, Thomas E.
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Schatzkin, Arthu ...
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Stevens, Victori ...
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Stolzenberg-Solo ...
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Virtamo, Jarmo
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Wolk, Alicja
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Ziegler, Regina ...
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Smith-Warner, St ...
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Journal of the N ...
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Uppsala universitet
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Karolinska Institutet