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The association between plasma proteomics and incident cardiovascular disease identifies MMP-12 as a promising cardiovascular risk marker in patients with chronic kidney disease
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- Rudholm Feldreich, Tobias (author)
- Högskolan Dalarna,Medicinsk vetenskap
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- Nowak, Christoph (author)
- Karolinska Institutet
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- Carlsson, Axel C. (author)
- Karolinska Institutet
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- Östgren, Carl Johan (author)
- Linköpings universitet,Avdelningen för prevention, rehabilitering och nära vård,Medicinska fakulteten,Region Östergötland, Vårdcentralen Ödeshög
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- Nyström, Fredrik H (author)
- Linköpings universitet,Avdelningen för diagnostik och specialistmedicin,Medicinska fakulteten,Region Östergötland, Vårdcentralen Cityhälsan Centrum
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- Sundström, Johan, Professor, 1971- (author)
- Uppsala universitet,Institutionen för medicinska vetenskaper,Uppsala Univ, Sweden
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- Carrero-Roig, Juan-Jesus (author)
- Karolinska Institutet
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- Leppert, Jerzy (author)
- Uppsala universitet,Centrum för klinisk forskning, Västerås,Uppsala Univ, Sweden
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- Hedberg, P (author)
- Uppsala universitet,Centrum för klinisk forskning, Västerås,Uppsala Univ, Sweden
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- Giedraitis, Vilmantas (author)
- Uppsala universitet,Geriatrik,Uppsala Univ, Sweden
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- Lind, Lars (author)
- Uppsala universitet,Institutionen för medicinska vetenskaper,Uppsala Univ, Sweden
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- Cordeiro, Antonio (author)
- Dante Pazzanese Inst Cardiol, Dept Hypertens & Nephrol, Sao Paulo, Brazil.
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- Ärnlöv, Johan, 1970- (author)
- Högskolan Dalarna,Karolinska Institutet,Medicinsk vetenskap
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(creator_code:org_t)
- ELSEVIER IRELAND LTD, 2020
- 2020
- English.
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In: Atherosclerosis. - : ELSEVIER IRELAND LTD. - 0021-9150 .- 1879-1484. ; 307, s. 11-15
- Related links:
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https://doi.org/10.1...
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https://uu.diva-port... (primary) (Raw object)
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http://www.atheroscl...
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https://liu.diva-por... (primary) (Raw object)
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https://du.diva-port... (primary) (Raw object)
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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http://kipublication...
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Abstract
Subject headings
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- Background and aims: Previous proteomics efforts in patients with chronic kidney disease (CKD) have predominantly evaluated urinary protein levels. Therefore, our aim was to investigate the association between plasma levels of 80 cardiovascular disease-related proteins and the risk of major adverse cardiovascular events (MACE) in patients with CKD. Methods: Individuals with CKD stages 3-5 (eGFR below 60 ml min-1 [1.73 m]-2) from three community-based cohorts (PIVUS, ULSAM, SAVA), one diabetes cohort (CARDIPP) and one cohort with peripheral artery disease patients (PADVA) with information on 80 plasma protein biomarkers, assessed with a proximity extension assay, and follow-up data on incident MACE, were used as discovery sample. To validate findings and to asses generalizability to patients with CKD in clinical practice, an outpatient CKD-cohort (Malnutrition, Inflammation and Vascular Calcification (MIVC)) was used as replication sample. Results: In the discovery sample (total n = 1316), 249 individuals experienced MACE during 7.0 +/- 2.9 years (range 0.005-12.9) of follow-up, and in the replication sample, 71 MACE events in 283 individuals over a mean +/- SD change of 2.9 +/- 1.2 years (range 0.1-4.0) were documented. Applying Bonferroni correction, 18 proteins were significantly associated with risk of MACE in the discovery cohort, adjusting for age and sex in order of significance, GDF-15, FGF-23, REN, FABP4, IL6, TNF-R1, AGRP, MMP-12, AM, KIM-1, TRAILR2, TNFR2, CTSL1, CSF1, PlGF, CA-125, CCL20 and PAR-1 (p < 0.000625 for all). Only matrix metalloproteinase 12 (MMP-12) was significantly associated with an increased risk of MACE in the replication sample (hazard ratio (HR) per SD increase, 1.36, 95% CI (1.07-1.75), p = 0.013). Conclusions: Our proteomics analyses identified plasma MMP-12 as a promising cardiovascular risk marker in patients with CKD.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Urologi och njurmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Urology and Nephrology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine (hsv//eng)
Keyword
- Proteomics
- Chronic kidney disease
- Community-based cohorts
- Cardiovascular risk marker
- Major adverse cardiovascular events
- Health and Welfare
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Rudholm Feldreic ...
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Nowak, Christoph
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Carlsson, Axel C ...
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Östgren, Carl Jo ...
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Nyström, Fredrik ...
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Sundström, Johan ...
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Carrero-Roig, Ju ...
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Leppert, Jerzy
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Hedberg, P
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Giedraitis, Vilm ...
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Lind, Lars
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Cordeiro, Antoni ...
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Ärnlöv, Johan, 1 ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cardiac and Card ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Urology and Neph ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
- Articles in the publication
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Atherosclerosis
- By the university
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Uppsala University
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Linköping University
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Karolinska Institutet
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Högskolan Dalarna