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Lymphopenia as a ri...
Lymphopenia as a risk factor for neurologic involvement and organ damage accrual in patients with systemic lupus erythematosus : A multi-center observational study
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- Yavuz, Sule (författare)
- Uppsala University,Uppsala universitet,Reumatologi,Department of Internal Medicine, Division of Rheumatology, Istanbul Bilim University, Istanbul, Turkey,Uppsala Univ, Sweden; Istanbul Bilim Univ, Turkey
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- Cansu, Dondu U. (författare)
- Eskisehir Osmangazi University,Eskisehir Osmangazi Univ, Turkey
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- Nikolopoulos, Dionysis (författare)
- Attikon University Hospital,Attikon Univ Hosp, Greece
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- Crisafulli, Francesca (författare)
- University of Brescia,Spedali Civil Brescia, Italy; Univ Brescia, Italy
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- Antunes, Ana M. (författare)
- Hospital Curry Cabral,University of Pisa,Ctr Hosp Lisboa Cent, Portugal,Univ Pisa, Italy
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- Adamichou, Christina (författare)
- University of Crete Medical School,Univ Crete, Greece
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- Reid, Sarah (författare)
- Uppsala University,Uppsala universitet,Reumatologi,Uppsala Univ, Sweden
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- Stagnaro, Chiara (författare)
- University of Pisa,Univ Pisa, Italy
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- Andreoli, Laura (författare)
- University of Brescia,Spedali Civil Brescia, Italy; Univ Brescia, Italy
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- Tincani, Angela (författare)
- University of Brescia,Spedali Civil Brescia, Italy; Univ Brescia, Italy
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- Moraes-Fontes, Maria Francisca (författare)
- Hospital Curry Cabral,Ctr Hosp Lisboa Cent, Portugal
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Mosca, Marta (författare)
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- Leonard, Dag, 1975- (författare)
- Uppsala University,Uppsala universitet,Reumatologi,Uppsala Univ, Sweden
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- Jönsen, Andreas (författare)
- Lund University,Lunds universitet,Lund SLE Research Group,Forskargrupper vid Lunds universitet,Lund University Research Groups,Skåne University Hospital,Lund Univ, Sweden
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- Bengtsson, Anders (författare)
- Lund University,Lunds universitet,Lund SLE Research Group,Forskargrupper vid Lunds universitet,Lund University Research Groups,Skåne University Hospital,Lund Univ, Sweden
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- Svenungsson, Elisabet (författare)
- Karolinska Institutet,Karolinska Inst, Sweden
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- Gunnarsson, Iva (författare)
- Karolinska Institutet,Karolinska Inst, Sweden
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- Rantapää-Dahlqvist, Solbritt (författare)
- Umeå University,Umeå universitet,Reumatologi,Umea Univ, Sweden
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- Sjöwall, Christopher (författare)
- Linköpings universitet,Linköping University,Avdelningen för inflammation och infektion,Medicinska fakulteten,Region Östergötland, Reumatologiska kliniken i Östergötland
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- Bertsias, George (författare)
- University of Crete Medical School,Univ Crete, Greece
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- Fanouriakis, Antonis (författare)
- Attikon University Hospital,Attikon Univ Hosp, Greece
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- Rönnblom, Lars (författare)
- Uppsala University,Uppsala universitet,Reumatologi,Uppsala Univ, Sweden
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(creator_code:org_t)
- Elsevier BV, 2020
- 2020
- Engelska.
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Ingår i: Seminars in Arthritis & Rheumatism. - : Elsevier BV. - 0049-0172 .- 1532-866X. ; 50:6, s. 1387-1393
- Relaterad länk:
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http://dx.doi.org/10...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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https://lup.lub.lu.s...
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http://kipublication...
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https://urn.kb.se/re...
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Abstract
Ämnesord
Stäng
- OBJECTIVE: Detailed analysis of hematological manifestations (HM) in systemic lupus erythematosus (SLE) are limited and their clinical impact on disease remain obscure. Here, we aimed to decipher factors associated with different hematological abnormalities in SLE patients and to assess their impact on disease related outcomes.METHODS: A dataset (GIPT) originating from SLE patients of six European tertiary centers was assessed. Six-monthly visits of each patient for at least 2 years were registered. The association between hematologic manifestations (HM; per ACR-1997criteria) and clinical/serologic variables, as well as the impact of HM on disease related outcomes (damage, infection and hemorrhage) were explored. Scores on the Systemic Lupus Erythematosus Disease Activity Index 2000(SLEDAI2K), the Systemic Lupus International Collaborating Clinics (SLICC)/American College of Rheumatology (ACR) Damage Index (SDI) and events for any infection and hemorrhage were recorded. Results were compared with a cross-sectional, well-characterized SLE dataset from Sweden. Descriptive statistics, the generalized estimating equations (GEE), general linear models (GLM), Cox regression models were applied.RESULTS: We monitored 1425 longitudinal visits in 286 SLE patients with HM (GIPT dataset: 88% female, 95% Caucasian, 68% dsDNA positive). Thrombocytopenia (regression coefficient [95% confidence interval] 1.86[1.1-3.13]) and neurologic involvement (ACR-8) (2.1[1.10-3.89]) were associated with lymphopenia (<1000/mm3); the latter was an independent predictor of organ damage accrual (1.68[1.2-2.62]). These associations were confirmed in an independent dataset of 1348 SLE patients (86% female, 93% Caucasian, 61% dsDNA positive) in Sweden.Severe lymphopenia (<500/mm3) and severe thrombocytopenia (<20 K/mm3) were associated with increased risk for infection (hazard ratio [95% confidence interval] 2.56[1.23-5.31]) and hemorrhage (4.38[2.10-11.1]), respectively, independent of the effect of other predictors.CONCLUSION: Lymphopenia in SLE is independently associated with neurologic involvement and organ damage accrual, and thus, may be considered as a marker of severe/progressive disease.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Reumatologi och inflammation (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Rheumatology and Autoimmunity (hsv//eng)
Nyckelord
- Medicinsk vetenskap
- Medical Science
- Medicinsk genetik
- Medical Genetics
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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- Av författaren/redakt...
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Yavuz, Sule
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Cansu, Dondu U.
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Nikolopoulos, Di ...
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Crisafulli, Fran ...
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Antunes, Ana M.
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Adamichou, Chris ...
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visa fler...
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Reid, Sarah
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Stagnaro, Chiara
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Andreoli, Laura
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Tincani, Angela
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Moraes-Fontes, M ...
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Mosca, Marta
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Leonard, Dag, 19 ...
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Jönsen, Andreas
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Bengtsson, Ander ...
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Svenungsson, Eli ...
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Gunnarsson, Iva
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Rantapää-Dahlqvi ...
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Sjöwall, Christo ...
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Bertsias, George
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Fanouriakis, Ant ...
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Rönnblom, Lars
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Karolinska Institutet
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