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Prevalence and risk...
Prevalence and risk factors of fatty liver in Portuguese adults
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- Leitao, Jorge (author)
- Ctr Hosp & Univ Coimbra, Dept Internal Med, Coimbra, Portugal.;Univ Coimbra, Fac Med, Coimbra, Portugal.
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- Carvalhana, Sofia (author)
- Ctr Hosp & Univ Lisboa Norte, Dept Gastroenterol, Lisbon, Portugal.
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- Cochicho, Joana (author)
- Ctr Hosp & Univ Coimbra, Dept Internal Med, Coimbra, Portugal.
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- Silva, Ana Paula (author)
- Ctr Hosp Vila Nova de Gaia & Espinho, Dept Gastroenterol, Vila Nova De Gaia, Portugal.
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- Velasco, Francisco (author)
- Hosp Faro, Dept Gastroenterol, Ctr Hosp Algarve, Faro, Portugal.
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- Medeiros, Isabel (author)
- Hosp Espirito Santo, Dept Gastroenterol, Evora, Portugal.
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- Alves, Ana Catarina (author)
- Inst Nacl Saude Dr Ricardo Jorge, Biosyst & Integrat Sci Inst BioISI, Lisbon, Portugal.
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- Bourbon, Mafalda (author)
- Inst Nacl Saude Dr Ricardo Jorge, Biosyst & Integrat Sci Inst BioISI, Lisbon, Portugal.
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- Oliveiros, Barbara (author)
- Univ Coimbra, Lab Biostat & Med Informat, Fac Med, Coimbra, Portugal.
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- Rodrigues, Vitor (author)
- Univ Coimbra, Inst Higiene & Med Social, Fac Med, Coimbra, Portugal.
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- Sousa, Rita (author)
- Univ Lisbon, Ctr Estudos Med Baseada Evidencia, Fac Med, Lisbon, Portugal.
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- Sampaio, Filipa, PhD, 1985- (author)
- Uppsala universitet,Institutionen för folkhälso- och vårdvetenskap,Univ Lisbon, Ctr Estudos Med Baseada Evidencia, Fac Med, Lisbon, Portugal.
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- Carvalho, Armando (author)
- Ctr Hosp & Univ Coimbra, Dept Internal Med, Coimbra, Portugal.;Univ Coimbra, Fac Med, Coimbra, Portugal.
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- Cortez-Pinto, Helena (author)
- Ctr Hosp & Univ Lisboa Norte, Dept Gastroenterol, Lisbon, Portugal.;Univ Lisbon, Clin Univ Gastrenterol, Fac Med, Lisbon, Portugal.
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Ctr Hosp & Univ Coimbra, Dept Internal Med, Coimbra, Portugal;Univ Coimbra, Fac Med, Coimbra, Portugal. Ctr Hosp & Univ Lisboa Norte, Dept Gastroenterol, Lisbon, Portugal. (creator_code:org_t)
- 2020-05-19
- 2020
- English.
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In: European Journal of Clinical Investigation. - : WILEY. - 0014-2972 .- 1365-2362. ; 50:6
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
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- Background Prevalence of fatty liver (FL) and nonalcoholic fatty liver disease (NAFLD) depends mainly on obesity, diabetes and genetic factors. FL and NAFLD prevalence was evaluated in Portuguese adult population and correlated with several risk factors and related mortality data, within the same period. Materials and methods A cross-sectional, population-based multicenter study, voluntary and randomly selected in 834 Portuguese adults (18-79 years). Participants were evaluated after 12-hour fasting. Anthropometric data, past history including alcohol consumption, and associated diseases were registered. Blood samples were collected for biochemical testing. Dietary intake was evaluated using a semi-quantitative food frequency questionnaire. Presence of FL was evaluated using ultrasound, and NAFLD was diagnosed after exclusion of other causes for liver disease. Results Adjusted prevalence of FL and NAFLD was 37.8% and 17.0%, respectively. FL individuals were older, more frequently males, with increased probability of having obesity, diabetes or harmful alcohol consumption (HAC). NAFLD individuals were also older, but had a similar sex distribution and an increased probability of obesity and diabetes. In both groups, no differences were found regarding dietary pattern or physical activity. During the same time period, nonalcoholic steatohepatitis (NASH) liver-related deaths in Portugal were 0.105/100 000, while alcohol-related liver disease mortality was 6.790/100 000. Conclusion The large spectrum of FL was present in more than one third of the population, although only less than half could be classified as NAFLD. Other significant risk factors, such as HAC, are probably implicated in FL, explaining the low NASH-related mortality compared with the high alcohol-related mortality during the same time period.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Gastroenterologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Gastroenterology and Hepatology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
Keyword
- alcohol consumption
- diabetes
- fatty liver
- mortality
- nonalcoholic fatty liver
- nutritional pattern
- obesity
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Leitao, Jorge
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Carvalhana, Sofi ...
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Cochicho, Joana
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Silva, Ana Paula
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Velasco, Francis ...
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Medeiros, Isabel
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Alves, Ana Catar ...
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Bourbon, Mafalda
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Oliveiros, Barba ...
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Rodrigues, Vitor
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Sousa, Rita
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Sampaio, Filipa, ...
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Carvalho, Armand ...
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Cortez-Pinto, He ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Gastroenterology ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Endocrinology an ...
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European Journal ...
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Uppsala University