Pregnancy-related risk factors for sex cord-stromal tumours and germ cell tumours in parous women: a registry-based study

Pregnancy-related risk factors for sex cord-stromal tumours and germ cell tumours in parous women : a registry-based study

BackgroundNon-epithelial ovarian cancers are divided into sex cord-stromal tumours (SCSTs) and germ cell tumours (GCTs). Whereas parity and other pregnancy-related factors are protective for epithelial ovarian cancer, their associations with SCSTs and GCTs remains unclear.MethodsUsing data from the medical birth registries from Denmark, Finland, Norway and Sweden, we compared all parous women with a diagnosis of SCSTs (n = 420) or GCTs (n = 345) 1970–2013 with up to 10 parous controls (SCSTs n = 4041; GCTs n = 2942) matched on the cases’ birth year and country. We used conditional logistic regression to estimate odds ratios (ORs) with 95% confidence intervals (CIs) of associations between pregnancy-related factors and SCSTs and GCTs.ResultsThe risk of SCSTs, but not GCTs, decreased with higher age at last birth [≥40 versus <25 years: OR 0.48 (95% CI 0.23–0.98)]. The risk of SCSTs (but not GCTs) also decreased with shorter time since last birth. Number of births, preterm birth, preeclampsia, and offspring size were not associated with risk of SCSTs or GCTs.ConclusionsWe found a decreased risk of SCSTs with higher age at last birth and shorter time since last birth. The risk of SCSTs (but not GCTs) may be influenced by the woman’s reproductive history.

Bjorge, ToneUniv Bergen, Dept Global Publ Hlth & Primary Care, Bergen, Norway.;Canc Registry Norway, Oslo, Norway. (author)
Ekbom, AndersKarolinska Institutet (author)
Engeland, AndersUniv Bergen, Dept Global Publ Hlth & Primary Care, Bergen, Norway.;Norwegian Inst Publ Hlth, Dept Chron Dis & Ageing, Bergen, Norway. (author)
Gissler, MikaKarolinska Institutet (author)
Grotmol, TomCanc Registry Norway, Oslo, Norway. (author)
Madanat-Harjuoja, LauraFinnish Canc Registry, Helsinki, Finland.;Univ Helsinki, Dept Pediat, Helsinki, Finland.;Helsinki Univ Hosp, Helsinki, Finland. (author)
Ording, Anne GulbechAarhus Univ Hosp, Dept Clin Epidemiol, Aarhus, Denmark. (author)
Trabert, BrittonNCI, Div Canc Epidemiol & Genet, NIH, Dept Hlth & Human Serv, Bethesda, MD 20892 USA. (author)
Tretli, SteinarCanc Registry Norway, Oslo, Norway. (author)
Troisi, RebeccaNCI, Div Canc Epidemiol & Genet, NIH, Dept Hlth & Human Serv, Bethesda, MD 20892 USA. (author)
Sorensen, Henrik ToftAarhus Univ Hosp, Dept Clin Epidemiol, Aarhus, Denmark. (author)
Glimelius, Ingrid,1975-Karolinska Institutet,Uppsala universitet,Experimentell och klinisk onkologi,Karolinska Inst, Dept Med, Div Clin Epidemiol, Stockholm, Sweden.(Swepub:uu)inggl846 (author)
Skold, A (author)
Uppsala universitetExperimentell och klinisk onkologi (creator_code:org_t)

In:British Journal of Cancer: Springer Nature123:1, s. 161-1660007-09201532-1827

By the author/editor: Sköld, Camilla; Bjorge, Tone; Ekbom, Anders; Engeland, Anders; Gissler, Mika; Grotmol, Tom; show more...; Madanat-Harjuoja ...; Ording, Anne Gul ...; Trabert, Britton; Tretli, Steinar; Troisi, Rebecca; Sorensen, Henrik ...; Glimelius, Ingri ...; Skold, A; show less...

About the subject

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Obstetrics Gynae ...

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Cancer and Oncol ...

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