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Sökning: WFRF:(Pasquini Marcelo) > (2020-2021) > Incidence, Risk Fac...

Incidence, Risk Factors for and Outcomes of Transplant-Associated Thrombotic Microangiopathy

Epperla, Narendranath (författare)
Ohio State Univ, James Canc Hosp, Dept Med, Div Hematol, Columbus, OH 43210 USA.;Ohio State Univ, Solove Res Inst, Columbus, OH 43210 USA.
Li, Ang (författare)
Univ Washington, Seattle, WA 98195 USA.
Logan, Brent (författare)
Med Coll Wisconsin, CIBMTR, Dept Med, Milwaukee, WI 53226 USA.;Med Coll Wisconsin, Inst Hlth & Equ, Div Biostat, Milwaukee, WI 53226 USA.
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Fretham, Caitrin (författare)
Be The Match, Natl Marrow Donor Program, CIBMTR, Minneapolis, MN USA.
Chhabra, Saurabh (författare)
Med Coll Wisconsin, CIBMTR, Dept Med, Milwaukee, WI 53226 USA.
Aljurf, Mahmoud (författare)
King Faisal Specialist Hosp Ctr & Res, Dept Oncol, Riyadh, Saudi Arabia.
Chee, Lynette (författare)
Royal Melbourne Hosp City Campus, Victoria, Australia.
Copelan, Edward (författare)
Atrium Hlth, Carolinas HealthCare Syst, Levine Canc Inst, Charlotte, NC USA.
Freytes, Cesar O. (författare)
Texas Transplant Inst, San Antonio, TX USA.
Hematti, Peiman (författare)
Univ Wisconsin, Dept Med, Div Hematol Oncol Bone Marrow Transplantat, Madison, WI USA.
Lazarus, Hillard M. (författare)
Case Western Reserve Univ, Cleveland, OH 44106 USA.
Litzow, Mark (författare)
Mayo Clin Rochester, Div Hematol, Rochester, MN USA.;Mayo Clin Rochester, Transplant Ctr, Rochester, MN USA.
Nishihori, Taiga (författare)
H Lee Moffitt Canc Ctr & Res Inst, Dept Blood & Marrow Transplant & Cellular Immunot, Tampa, FL USA.
Olsson, Richard (författare)
Karolinska Institutet,Uppsala universitet,Centrum för klinisk forskning i Sörmland (CKFD),Karolinska Inst, Dept Lab Med, Stockholm, Sweden.
Prestidge, Tim (författare)
Starship Childrens Hosp, Blood & Canc Ctr, Auckland, New Zealand.
Saber, Wael (författare)
Med Coll Wisconsin, CIBMTR, Dept Med, Milwaukee, WI 53226 USA.
Wirk, Baldeep (författare)
Seattle Canc Care Alliance, Div Bone Marrow Transplant, Seattle, WA USA.
Yared, Jean A. (författare)
Univ Maryland, Greenebaum Comprehens Canc Ctr, Div Hematol Oncol, Dept Med,Blood & Marrow Transplantat Program, Baltimore, MD 21201 USA.
Loren, Alison (författare)
Univ Penn, Perelman Sch Med, Dept Med, Div Hematol Oncol, Philadelphia, PA 19104 USA.
Pasquini, Marcelo (författare)
Med Coll Wisconsin, CIBMTR, Dept Med, Milwaukee, WI 53226 USA.
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Ohio State Univ, James Canc Hosp, Dept Med, Div Hematol, Columbus, OH 43210 USA;Ohio State Univ, Solove Res Inst, Columbus, OH 43210 USA. Univ Washington, Seattle, WA 98195 USA. (creator_code:org_t)
2020-03-02
2020
Engelska.
Ingår i: British Journal of Haematology. - : WILEY. - 0007-1048 .- 1365-2141. ; 189:6, s. 1171-1181
Relaterad länk:
https://onlinelibrar...
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https://urn.kb.se/re...
https://doi.org/10.1...
http://kipublication...
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  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
Stäng  
  • Transplant-associated thrombotic microangiopathy (TA-TMA) is a complication of allogeneic transplantation (allo-HCT). The incidence and risk factors associated with TA-TMA are not well known. A retrospective analysis from the Center for International Blood and Marrow Transplant Research (CIBMTR) was conducted including patients receiving allo-HCT between 2008 and 2016, with the primary objective of evaluating the incidence of TA-TMA. Secondary objectives included identification of risk factors associated with TA-TMA, and the impact of TA-TMA on overall survival and the need for renal replacement therapy (RRT). Among 23,665 allo-HCT recipients, the 3-year cumulative incidence of TA-TMA was 3%. Variables independently-associated with increased incidence of TA-TMA included female sex, prior autologous transplant, primary disease (acute lymphoblastic leukaemia and severe aplastic anaemia), donor type (mismatched or unrelated donor), conditioning intensity (myeloablative), GVHD prophylaxis (sirolimus + calcineurin inhibitor), pre-transplant kidney dysfunction and acute GVHD (time-varying effect). TA-TMA was associated with higher mortality (HR = 3 center dot 1, 95% Confidence Interval [CI] = 2 center dot 8-16 center dot 3) and RRT requirement (HR = 7 center dot 1, 95% CI = 5 center dot 7-311 center dot 6). This study provides epidemiologic data on TA-TMA and its impact on transplant outcomes. Increased awareness of the risk factors will enable providers to be vigilant of this uncommon but serious transplant complication. The results will also provide benchmarking for future study designs and comparisons.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Hematologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Hematology (hsv//eng)

Nyckelord

thrombotic microangiopathy
TA-TMA
allogeneic transplantation
allo-HCT

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