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A Grading System fo...
A Grading System for Invasive Pulmonary Adenocarcinoma : A Proposal From the International Association for the Study of Lung Cancer Pathology Committee
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- Moreira, Andre L. (author)
- New York Univ Langone Hlth, Dept Pathol, 560 First Ave,TH 4-15B, New York, NY 10016 USA.
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- Ocampo, Paolo S. S. (author)
- New York Univ Langone Hlth, Dept Pathol, 560 First Ave,TH 4-15B, New York, NY 10016 USA.
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- Xia, Yuhe (author)
- New York Univ Langone Hlth, Dept Biostat, New York, NY 10016 USA.
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- Zhong, Hua (author)
- New York Univ Langone Hlth, Dept Biostat, New York, NY 10016 USA.
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- Russell, Prudence A. (author)
- St Vincents Hosp, Dept Pathol, Fitzroy, Vic, Australia.
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- Minami, Yuko (author)
- Ibarakihigashi Natl Hosp, Dept Pathol, Tokai, Ibaraki, Japan.
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- Cooper, Wendy A. (author)
- Royal Prince Alfred Hosp, Dept Pathol, Camperdown, NSW, Australia.
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- Yoshida, Akihiko (author)
- Natl Canc Ctr, Dept Diagnost Pathol, Tokyo, Japan.
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- Bubendorf, Lukas (author)
- Univ Basel, Univ Hosp Basel, Inst Med Genet & Pathol, Basel, Switzerland.
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- Papotti, Mauro (author)
- Univ Turin, Dept Oncol, Turin, Italy.
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- Pelosi, Giuseppe (author)
- Univ Milan, Dept Pathol, Milan, Italy.;IRCCS MultiMed, Milan, Italy.
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- Lopez-Rios, Fernando (author)
- HM Hosp, Pathol Lab Dianas Terapeut, Madrid, Spain.
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- Kunitoki, Keiko (author)
- Harvard TH Chan Sch Publ Hlth, Boston, MA USA.
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- Ferrari-Light, Dana (author)
- New York Univ Langone Hlth, Dept Surg, New York, NY 10016 USA.
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- Sholl, Lynette M. (author)
- Harvard Med Sch, Brigham & Womens Hosp, Dept Pathol, Boston, MA 02115 USA.
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- Beasley, Mary Beth (author)
- Mt Sinai Hlth Syst, Icahn Sch Med, Dept Pathol, New York, NY USA.
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- Borczuk, Alain (author)
- Weill Cornell Med, Dept Pathol, New York, NY USA.
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- Botling, Johan (author)
- Uppsala universitet,Klinisk och experimentell patologi,Johan Botling
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- Brambilla, Elisabeth (author)
- Univ Grenoble Alpes, Dept Anat Pathol & Cytol, Grenoble, France.
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- Chen, Gang (author)
- Fudan Univ, Zhongshan Hosp, Dept Pathol, Shanghai, Peoples R China.
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- Chou, Teh-Ying (author)
- Taipei Vet Gen Hosp, Dept Pathol, Taipei, Taiwan.
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- Chung, Jin-Haeng (author)
- Seoul Natl Univ, Dept Pathol, Bundang Hosp, Seoul, South Korea.
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- Dacic, Sanja (author)
- Univ Pittsburgh, Dept Pathol, Med Ctr, Pittsburgh, PA USA.
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- Jain, Deepali (author)
- All India Inst Med Sci, Dept Pathol, New Delhi, India.
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- Hirsch, Fred R. (author)
- Tisch Canc Inst, Ctr Thorac Oncol, New York, NY USA.
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- Hwang, David (author)
- Sunnybrook Hlth Sci Ctr, Dept Lab Med & Mol Diagnost, Toronto, ON, Canada.
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- Lantuejoul, Sylvie (author)
- Ctr Leon Berard Unicanc, Dept Pathol, Lyon, France.
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- Lin, Dongmei (author)
- Peking Univ, Dept Pathol, Canc Hosp & Inst, Beijing, Peoples R China.
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- Longshore, John W. (author)
- Atrium Hlth, Carolinas Pathol Grp, Charlotte, NC USA.
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- Motoi, Noriko (author)
- Natl Canc Ctr, Dept Diagnost Pathol, Tokyo, Japan.
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- Noguchi, Masayuki (author)
- Univ Tsukuba, Dept Pathol, Tsukuba, Ibaraki, Japan.
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- Poleri, Claudia (author)
- Off Pathol Consultants, Buenos Aires, DF, Argentina.
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- Rekhtman, Natasha (author)
- Mem Sloan Kettering Canc Ctr, Dept Pathol, 1275 York Ave, New York, NY 10021 USA.
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- Tsao, Ming-Sound (author)
- Univ Hlth Network, Princess Margaret Canc Ctr, Toronto, ON, Canada.
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- Thunnissen, Erik (author)
- Vrije Univ Amsterdam Med Ctr, Dept Pathol, Amsterdam, Netherlands.
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- Travis, William D. (author)
- Mem Sloan Kettering Canc Ctr, Dept Pathol, 1275 York Ave, New York, NY 10021 USA.
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- Yatabe, Yasushi (author)
- Natl Canc Ctr, Dept Diagnost Pathol, Tokyo, Japan.
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- Roden, Anja C. (author)
- Mayo Clin, Dept Lab Med & Pathol, Rochester, MN USA.
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- Daigneault, Jillian B. (author)
- Int Assoc Study Lung Canc, Aurora, CO USA.
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- Wistuba, Ignacio I. (author)
- Univ Texas MD Anderson Canc Ctr, Dept Pathol, Houston, TX 77030 USA.
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- Kerr, Keith M. (author)
- Aberdeen Royal Infirm, Dept Pathol, Aberdeen, Scotland.
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- Pass, Harvey (author)
- New York Univ Langone Hlth, Dept Surg, New York, NY 10016 USA.
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- Nicholson, Andrew G. (author)
- Royal Brompton & Harefield NHS Fdn Trust, Dept Pathol, London, England.;Imperial Coll, Natl Heart & Lung Inst, London, England.
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- Mino-Kenudson, Mari (author)
- Harvard Med Sch, Dept Pathol, Massachusetts Gen Hosp, Boston, MA 02115 USA.
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New York Univ Langone Hlth, Dept Pathol, 560 First Ave,TH 4-15B, New York, NY 10016 USA New York Univ Langone Hlth, Dept Biostat, New York, NY 10016 USA. (creator_code:org_t)
- ELSEVIER SCIENCE INC, 2020
- 2020
- English.
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In: Journal of Thoracic Oncology. - : ELSEVIER SCIENCE INC. - 1556-0864 .- 1556-1380. ; 15:10, s. 1599-1610
- Related links:
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https://urn.kb.se/re...
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Abstract
Subject headings
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- Introduction: A grading system for pulmonary adenocarcinoma has not been established. The International Association for the Study of Lung Cancer pathology panel evaluated a set of histologic criteria associated with prognosis aimed at establishing a grading system for invasive pulmonary adenocarcinoma. Methods: A multi-institutional study involving multiple cohorts of invasive pulmonary adenocarcinomas was conducted. A cohort of 284 stage I pulmonary adenocarcinomas was used as a training set to identify histologic features associated with patient outcomes (recurrence-free survival [RFS] and overall survival [OS]). Receiver operating characteristic curve analysis was used to select the best model, which was validated (n = 212) and tested (n = 300, including stage I-III) in independent cohorts. Reproducibility of the model was assessed using kappa statistics. Results: The best model (area under the receiver operating characteristic curve [AUC] = 0.749 for RFS and 0.787 for OS) was composed of a combination of predominant plus high-grade histologic pattern with a cutoff of 20% for the latter. The model consists of the following: grade 1, lepidic predominant tumor; grade 2, acinar or papillary predominant tumor, both with no or less than 20% of high-grade patterns; and grade 3, any tumor with 20% or more of high-grade patterns (solid, micropapillary, or complex gland). Similar results were seen in the validation (AUC = 0.732 for RFS and 0.787 for OS) and test cohorts (AUC = 0.690 for RFS and 0.743 for OS), confirming the predictive value of the model. Interobserver reproducibility revealed good agreement (k = 0.617). Conclusions: A grading system based on the predominant and high-grade patterns is practical and prognostic for invasive pulmonary adenocarcinoma. (C) 2020 International Association for the Study of Lung Cancer. Published by Elsevier Inc. All rights reserved.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Klinisk laboratoriemedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Clinical Laboratory Medicine (hsv//eng)
Keyword
- Adenocarcinoma
- Tumor grading
- Lung
- Model
- Prognosis
- Patologi
- Pathology
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Moreira, Andre L ...
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Ocampo, Paolo S. ...
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Xia, Yuhe
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Zhong, Hua
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Russell, Prudenc ...
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Minami, Yuko
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show more...
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Cooper, Wendy A.
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Yoshida, Akihiko
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Bubendorf, Lukas
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Papotti, Mauro
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Pelosi, Giuseppe
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Lopez-Rios, Fern ...
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Kunitoki, Keiko
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Ferrari-Light, D ...
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Sholl, Lynette M ...
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Beasley, Mary Be ...
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Borczuk, Alain
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Botling, Johan
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Brambilla, Elisa ...
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Chen, Gang
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Chou, Teh-Ying
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Chung, Jin-Haeng
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Dacic, Sanja
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Jain, Deepali
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Hirsch, Fred R.
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Hwang, David
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Lantuejoul, Sylv ...
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Lin, Dongmei
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Longshore, John ...
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Motoi, Noriko
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Noguchi, Masayuk ...
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Poleri, Claudia
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Rekhtman, Natash ...
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Tsao, Ming-Sound
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Thunnissen, Erik
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Travis, William ...
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Yatabe, Yasushi
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Roden, Anja C.
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Daigneault, Jill ...
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Wistuba, Ignacio ...
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Kerr, Keith M.
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Pass, Harvey
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Nicholson, Andre ...
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Mino-Kenudson, M ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cancer and Oncol ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Clinical Laborat ...
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Uppsala University